White Sox vs Orioles Prediction 9/15/25 MLB Picks Today

In this article we will formulate a White Sox vs Orioles prediction for this MLB game on Monday, September 15th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 57-93 this year after they lost all three games against Cleveland by scores of 0-4, 1-3, and 2-3. In their game three loss, Chicago tied the game at two in the fifth inning, but allowed the winning run in the seventh in the defeat. The White Sox recorded five hits in the game and they were led by Vargas and Meidroth, who both had one RBI in the loss. Chicago started Gomez, who allowed two hits and two earned runs over 5.0 innings, while Eisert picked up the loss in relief. 

Prior to that series, the White Sox won two out of three against the Rays and two out of three against the Tigers. Chicago has lost four of their last six games and they are last in the AL Central standings. The Chicago pitching staff has a 4.21 ERA with a 1.36 WHIP and a .247 opponent batting average, while the offense has scored 600 runs with a .234 batting average and a .303 on base percentage this season. Lenyn Sosa has led Chicago with 20 home runs and 68 RBIs, while Andrew Benintendi has added 19 home runs and 60 RBIs this year. The projected starting pitcher for Chicago is Sean Burke, who is 4-10 with a 4.35 ERA and a 1.47 WHIP over 122.0 innings pitched this year. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 69-80 this season after they lost all three against Toronto by scores of 1-6, 4-5, and 2-11. In their game three loss, Baltimore led 1-0 in the second, but only scored once in the last seven innings for the loss. The Orioles recorded seven hits in the game and they were led by Mayo and Cowser, who both had one RBI in the loss. Baltimore started Suarez, who allowed two hits and one earned run over 3.0 innings, while Wolfram picked up the loss in relief. 

Prior to that series, the Orioles won all three against the Pirates and two out of three against the Dodgers. Baltimore has split their last six games and they are last in the AL East standings. The Baltimore pitching staff has a 4.63 ERA with a 1.38 WHIP and a .261 opponent batting average, while their offense has scored 635 runs with a .239 batting average and a .306 on base percentage this season. Jackson Holliday has led Baltimore with 17 home runs and 55 RBIs, while Gunnar Henderson has added 16 home runs and 62 RBIs this year. The projected starting pitcher for Baltimore is Kyle Bradish, who is 0-1 with a 2.65 ERA and a 0.94 WHIP over 17.0 innings pitched this season. 

Why the White Sox will beat the Orioles

• The Orioles have lost each of their last seven games against American League opponents.
• The home team has won each of the Orioles’ last six games.
• The White Sox have covered the run line each of their last eight games against teams that held a losing record.
• The Orioles have failed to cover the run line in each of their last seven games as favorites against American League opponents.
• The Orioles have trailed after 5 innings in five of their last six night games against AL Central opponents that held a losing record.
• The Orioles have lost the first inning in each of their last four road games against opponents that held a losing record.
• The White Sox have led after 3 innings in four of their last five home games against opponents that held a losing record.

Total Runs Facts

• Each of the White Sox’s last four games have gone UNDER the total runs line.
• Each of the Orioles’ last four night games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last six games as favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight games against AL East opponents.

Chicago White Sox Player Prop Facts

• Mike Tauchman has hit a home run in two of his last three appearances against the Orioles after playing the previous day.
• Andrew Benintendi has recorded at least one hit in each of his last nine home appearances.

Baltimore Orioles Player Prop Facts

• Tyler O’Neill has hit a home run in four of his last five appearances with the Orioles as favorites.
• Gunnar Henderson has recorded at least one hit in each of the Orioles’ last 10 games as favorites against AL opponents.
• Ryan Mountcastle has recorded a Double in three of the Orioles’ last four road games against the White Sox.

Matchup/League Facts

• The White Sox rank 29th in the league for walks allowed this season (551).
• The White Sox rank 28th in the league for slugging percentage this season (.375).
• The Orioles rank 28th in the league for opponent batting average this season (.261).
• The Orioles rank 28th in the league for hits allowed this season (1333).

White Sox vs Orioles Prediction 

Both of these teams were swept over the weekend and will be looking to get back on the right track here. Chicago is 32-43 at home this season, while Baltimore is 33-42 on the road. Baltimore allowed 22 runs in their three games against Toronto and they are starting Bradish, who has allowed two earned runs or fewer in three straight outings. Chicago is going with Burke, who has allowed three earned runs or fewer in five straight. Both of these pitchers have been solid in recent outings, but we have seen Chicago play much better at home. Take the White Sox here.