White Sox vs Padres Prediction 9/20/25 MLB Picks Today

In this article we will formulate a White Sox vs Padres prediction for this MLB game on Saturday, September 20th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 58-96 this year after they won game one by a score of 4-3 on Friday night. Chicago scored two runs in the fourth inning, which turned out to be the difference in the close win. The White Sox recorded four hits in the game and they were led by Vargas, who went 1-3 with one home run and two RBIs in the win. Chicago started Martin, who allowed six hits and three earned runs over 6.0 innings for the win, while Taylor got the save. 

Prior to this series, the White Sox lost all three against the Orioles and all three against the Guardians. Chicago has lost six of their last seven games and they are still last in the Central. The Chicago pitching staff has a 4.22 ERA with a 1.36 WHIP and a .247 opponent batting average, while the offense has scored 613 runs with a .233 batting average and a .302 on base percentage this season. Lenyn Sosa has led Chicago with 20 home runs and 70 RBIs, while Andrew Benintendi has added 20 home runs and 62 RBIs this year. The projected starting pitcher for Chicago is Yoendrys Gomez, who is 3-2 with a 4.91 ERA and a 1.42 WHIP over 51.1 innings pitched this year. 

San Diego Padres Betting Preview

The San Diego Padres are 83-71 this season after they lost game one by a score of 4-3 last night. San Diego tied the game at two in the fourth inning, but only scored once in the final five innings for the bad loss. The Padres recorded seven hits in the game and they were led by Arraez, Sheets, and O’Hearn, who all had one RBI in the loss. SD started Cease, who allowed four hits and four earned runs over 6.0 innings for the loss, while Estrada and Peralta finished the game. 

Prior to this series, the Padres lost two out of three against the Mets, but did win three out of four against the Rockies before that. San Diego has lost three of their last four games and they are second in the NL West standings. The San Diego pitching staff has a 3.70 ERA with a 1.20 WHIP and a .226 opponent batting average, while their offense has scored 655 runs with a .252 batting average and a .320 on base percentage this season. Manny Machado has led San Diego with 26 home runs and 92 RBIs, while Fernando Tatis has added 22 home runs and 65 RBIs this year. The projected starting pitcher for San Diego is Yu Darvish, who is 4-5 with a 5.63 ERA and a 1.14 WHIP over 62.1 innings pitched this season. 

Why the Padres will beat the White Sox

• The White Sox have lost each of their last 12 Saturday night games against teams that held a winning record.
• The Padres have won each of their last nine Saturday games against AL Central opponents.
• The White Sox have failed to cover the run line each of their last 12 Saturday night games against teams that held a winning record.
• The Padres have covered the run line in each of their last eight Saturday games against AL Central opponents.
• The White Sox have trailed after 5 innings in three of their last four night games against opponents that held a winning record.
• The Padres have led after 3 innings in six of their last seven games against opponents that held a losing record.

Total Runs Facts

• Each of the White Sox’s last seven games as underdogs have gone UNDER the total runs line.
• Seven of the Padres’ last eight games as favorites against the White Sox have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last eight home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last seven games.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in each of the White Sox’s last two games against the Padres.
• Andrew Benintendi has recorded at least one hit in each of his last 11 Saturday appearances at Rate Field.

San Diego Padres Player Prop Facts

• Xander Bogaerts has recorded a Double in each of his last three road appearances against opponents that held a losing record.
• Yu Darvish has recorded seven or more strikeouts in 14 of his last 16 Saturday appearances in night games.
• Elias Diaz has hit a home run in each of his last two appearances with his team as a favorite against the White Sox.
• Luis Arraez has recorded at least one hit in each of the Padres’ last 23 games as favorites against AL opponents.

White Sox vs Padres Prediction 

Chicago snapped their long losing streak with a win on Friday night, which really hurt the Padres in their NL West race. The White Sox are 33-46 at home this year, while the Padres are 36-43 on the road. San Diego is not playing their best right now and they are starting Darvish, who has allowed 3+ earned runs in four straight starts. Chicago is starting Gomez, who has allowed 2, 4, 1, and 4 earned runs in his last four outings. I am going to back the Padres once again here, as I don’t trust the Chicago lineup, but this San Diego team is not playing great right now.