White Sox vs Pirates Prediction 9/10/26 MLB Picks Today
Pittsburgh Pirates (73-73) vs. Chicago White Sox (75-70)
September 10, 2026 7:40 pm EDT
The Line: Chicago White Sox -107 / Pittsburgh Pirates -113; Over/Under: 7.5
(Get latest betting odds)
The Pittsburgh Pirates and Chicago White Sox meet Thursday in MLB action at Rate Field. Here’s a White Sox vs Pirates Prediction. This article will include a White Sox vs Pirates Pick.
Pittsburgh Pirates Betting Preview
The Pittsburgh Pirates are 73-73 this year and play the Cubs and Brewers next. The Pittsburgh Pirates are batting .254 on the season, with a .331 OBP and a .403 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 4.15 ERA and a 1.30 WHIP. Nick Gonzales leads the Pittsburgh Pirates with 155 hits and 59 RBI, while Bryan Reynolds and Brandon Lowe have combined for 282 hits and 152 RBI.
Jared Jones gets the ball for the Pittsburgh Pirates, and he is 3-6 with a 4.46 ERA and 92 strikeouts this season. This will be Jones’ first career game against the Chicago White Sox.
Chicago White Sox Betting Preview
The Chicago White Sox are 75-70 on the year and play the Guardians and Cardinals next. The Chicago White Sox are batting .236 on the season, have a .319 OBP, and have a .407 slugging percentage. The Chicago White Sox pitching staff has a 4.14 ERA and a 1.31 WHIP. Chase Meidroth leads the Chicago White Sox with 138 hits and 51 RBI, while Sam Antonacci and Miguel Vargas have combined for 247 hits and 123 RBI.
Hagen Smith gets the ball for the Chicago White Sox, and he is 3-1 with a 0.56 ERA and 23 strikeouts this season. This will be Smith’s first career game against the Pittsburgh Pirates.
Why the Chicago White Sox will win
- The underdogs have won each of the last five games between the Pirates and White Sox.
- The Pirates have lost three of their last five games as road favorites against AL opponents.
- The Pirates have failed to cover the run line in each of their last nine games as favorites following a win.
- The White Sox have covered the run line in each of their last nine games as home underdogs against NL opponents following a loss.
- The White Sox have won the first inning in three of their last four games as underdogs against the Pirates.
- The Pirates have trailed after 3 innings in three of their last four games as road favorites against AL opponents.
Why the Pittsburgh Pirates will win
- The road team has won each of the last eight games between the Pirates and White Sox.
- The White Sox have lost 18 of their last 19 games as home underdogs against NL Central opponents following a loss.
- The road team has covered the run line in each of the last 10 games between the Pirates and White Sox.
- The White Sox have failed to cover the run line in each of their last four games as underdogs.
- The Pirates have led after 5 innings in each of their last nine games against AL Central opponents that held a winning record.
- The White Sox have lost the first inning in four of their last five games as underdogs against NL Central opponents.
- The White Sox have trailed after 3 innings in seven of their last eight games as home underdogs against NL opponents.
Total Runs Facts
- Each of the Pirates’ last five games as favorites against AL opponents have gone UNDER the total runs line.
- Nine of the White Sox’s last 11 night games as underdogs have gone OVER the total runs line.
- There has been no run scored during the first inning in nine of the Pirates’ last 10 road games against AL Central opponents.
- There has been at least one run scored in the first inning in eight of the White Sox’s last nine games as underdogs against NL Central opponents.
Chicago White Sox Player Prop Facts
- Tristan Peters has hit a home run in each of the White Sox’s last two games as home underdogs.
- Sam Antonacci has recorded at least one hit in each of the White Sox’s last seven home games against NL Central opponents.
Pittsburgh Pirates Player Prop Facts
- Jared Jones has recorded seven or more strikeouts in each of his last three appearances against AL opponents.
- Nick Gonzales has recorded at least one hit in each of his last 11 road appearances against AL opponents that held a winning record.
- Esmerlyn Valdez has hit a home run in each of his last two road appearances after playing the previous day.
White Sox vs Pirates Prediction
I’m not thrilled to get behind Smith and his small sample size of 16 innings, but the White Sox have been the most profitable team in baseball, and we’ve backed them all year. The fact that you can still get the White Sox at this price while they’re fighting for a playoff spot and playing bottom feeders is beyond me. Jones has a 4.46 ERA and 1.23 WHIP, and he’s allowed 17 runs in his last 26.2 innings. The Pirates have lost 7 of their last 8 games Jones has pitched. I’ll gladly back the White Sox like I have all season.