White Sox vs Red Sox Prediction 4/12/25 MLB Picks Today

The Boston Red Sox and the Chicago White Sox meet Saturday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a White Sox vs Red Sox Prediction.

Starting Pitching Matchup

The Boston Red Sox will send out Richard Fitts for the start here and Fitts is 0-2 with a 4.50 ERA and 8 strikeouts this season. This will be Fitts’ second career start against the White Sox. The Chicago White Sox will send out Martin Perez for the start here and is 1-0 with a 0.73 ERA and 13 strikeouts this season. In his last five starts against the Red Sox, Perez is 2-1 with a 3.54 ERA and 22 strikeouts.

Boston Red Sox Recap

The Boston Red Sox come into this game looking to bounce back after ending up with an 11-1 loss to start the series on Friday. After this series, the Red Sox will head on the road again for a division set against the Tampa Bay Rays.

Red Sox Drop 4 Of Their Last 5

Alex Bregman leads the Red Sox with 18 hits including a team-high 6 doubles with 2 home runs and 12 RBIs while Kristian Campbell has 16 hits with 4 doubles, 2 homers and 5 RBIs. Wilyer Abreu’s added 16 hits with a team-high 3 home runs, 12 RBIs and a .364 batting average. Jarren Duran and Trevor Story have each chipped in a team-high 5 stolen bases while Rafael Devers has the dubious distinction of leading the Red Sox with 21 strikeouts so far this season.

Why the Boston Red Sox will win

• The White Sox have lost each of their last seven games against teams that held a losing record.
• The Red Sox have won 13 of their last 15 games against the White Sox following a road loss.
• The White Sox have failed to cover the run line in seven of their last eight games against AL East opponents that held a losing record.
• The Red Sox have covered the run line in each of their last four games as favorites against AL Central opponents following a loss.

Boston Red Sox Player Prop Facts

• Jarren Duran has scored at least one run in nine of the Red Sox’s last 10 day games against opponents that held a losing record.
• Alex Bregman has recorded at least one Single in eight of his last nine appearances in day games against AL teams that held a losing record.
• Alex Bregman has recorded at least one hit in each of his last 14 road appearances against AL Central opponents.
• Connor Wong has recorded an RBI in each of his last four appearances against AL Central opponents.
• Triston Casas has hit at least one home run in three of his last four Saturday appearances against teams that held a losing record.
• Connor Wong has recorded a Double in each of his last three appearances in day games against teams that held a losing record.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to build some momentum after ending up with the big win in Friday’s series opener. After this series, the White Sox will welcome the Athletics to town.

White Sox Snap Eight-Game Losing Streak

Lenyn Sosa leads the White Sox with 10 hits including a pair of doubles and 5 RBIs. Andrew Benintendi has 9 hits including 2 home runs, 6 RBIs and a .290 batting average while Miguel Vargas has a team-high 3 doubles and 6 RBIs. Brooks Baldwin has also added 6 RBIs while Luis Robert Jr. has a team-high 5 stolen bases so far this season. Nick Maton also has a pair of home runs for the White Sox as well this season.

Why the Chicago White Sox will win

• The home team has won each of the White Sox’s last seven games.
• The Red Sox have lost four of their last five games as favorites.
• The White Sox have covered the run line in each of their last seven day games following a win.
• The Red Sox have failed to cover the run line in each of their last five games.

Chicago White Sox Player Prop Facts

• Luis Robert has hit at least one home run in three of his last four home appearances against the Red Sox after playing the previous day.
• Martin Perez has recorded a win in four of his last five appearances against opponents that held a losing record.
• Martin Perez has recorded six or more strikeouts in each of his last four home appearances against opponents that held a losing record.
• Andrew Benintendi has recorded a Double in three of his last four home appearances against former teams.
• Josh Rojas has scored at least one run in five of his last six appearances at Rate Field.
• Omar Narvaez has recorded at least one RBI in nine of his last 10 home appearances against AL East opponents that held a losing record.
• Andrew Benintendi has recorded at least one hit in each of his last 11 home appearances against opponents that held a losing record.
• Omar Narvaez has recorded a Single in nine of his last 10 home appearances against AL East opponents that held a losing record.

Total Runs Facts

• Eight of the Red Sox’s last nine games as favorites against American League opponents have gone UNDER the total runs line.
• Four of the White Sox’s last five home games against AL East opponents have gone OVER the total runs line.

White Sox vs Red Sox Prediction

I’m on the White Sox +1.5 here. I get why the Red Sox would be favored in this spot, but Martin Perez has pitched really well up to this point in the year. If the White Sox saved any offense for Saturday’s matchup, they’ll be in a pretty good spot. The Red Sox have never won a game started by Richard Fitts, going 0-6 all time, and I’m just not impressed with Boston right now. Give me the White Sox +1.5 in this one.