White Sox vs Rockies Prediction 9/25/26 MLB Picks Today
Colorado Rockies (57-102) vs. Chicago White Sox (82-77)
September 25, 2026 7:40 pm EDT
The Line: Chicago White Sox -230 / Colorado Rockies 187; Over/Under: 8
(Get latest betting odds)
The Los Angeles Angels and Chicago White Sox meet Friday in MLB action at Rate Field. Here’s a White Sox vs. Rockies Prediction. This article will include a White Sox vs. Rockies Pick.
Colorado Rockies Betting Preview
The Colorado Rockies are 57-102 on the year. The Colorado Rockies are batting .254 on the season and have a .323 OBP and a .417 slugging percentage. The Colorado Rockies’ pitching staff has a 5.59 ERA and a 1.53 WHIP. TJ Rumfield leads the Colorado Rockies with 161 hits and 71 RBI, while Jake McCarthy and Hunter Goodman have combined for 282 hits and 167 RBI.
Tomoyuki Sugano gets the ball for the Colorado Rockies, and he is 12-11 with a 5.36 ERA and 91 strikeouts this season. This will be Sugano’s first career game against the Chicago White Sox.
Chicago White Sox Betting Preview
The Chicago White Sox are 82-77 on the year. The Chicago White Sox are batting .236 on the season, have a .321 OBP, and have a .404 slugging percentage. The Chicago White Sox pitching staff has a 4.13 ERA and a 1.32 WHIP. Chase Meidroth leads the Chicago White Sox with 155 hits and 63 RBI, while Sam Antonacci and Miguel Vargas have combined for 274 hits and 140 RBI.
Sean Burke gets the ball for the Chicago White Sox, and he is 10-7 with a 3.40 ERA and 178 strikeouts this season. This will be Burke’s first career game against the Colorado Rockies.
Why the Chicago White Sox will win
- The Rockies have lost each of their last 10 road games.
- The White Sox have won each of their last five night games against NL West opponents that held a losing record.
- The Rockies have failed to cover the run line in each of their last six road games.
- The White Sox have covered the run line in each of their last four night games against NL West opponents.
- The Rockies have trailed after 5 innings in each of their last 14 night games against opponents that held a winning record.
- The Rockies have lost the first inning in each of their last six night games.
- The Rockies have trailed after 3 innings in eight of their last nine games against opponents that held a winning record.
Why the Colorado Rockies will win
- The White Sox have lost each of their last eight games against NL opponents following a win.
- The road team has won seven of the Rockies’ last eight games.
- The White Sox have failed to cover the run line in each of their last 14 games as favorites following a road win.
- The underdogs have covered the run line in each of the last four games between the Rockies and White Sox.
- The White Sox have trailed after 5 innings in seven of their last eight home games against NL opponents.
- The White Sox have lost the first inning in three of their last four games against NL West opponents.
- The White Sox have trailed after 3 innings in each of their last four games against NL West opponents.
Total Runs Facts
- Each of the White Sox’s last four games have gone OVER the total runs line.
- Each of the Rockies’ last four night games as underdogs have gone UNDER the total runs line.
- There has been at least one run scored in the first inning in each of the Rockies’ last seven night games.
- There has been at least one run scored in the first inning in each of the White Sox’s last five night games.
Chicago White Sox Player Prop Facts
- Miguel Vargas has hit a home run in six of the White Sox’s last seven Friday games as favorites.
- Sam Antonacci has recorded at least one hit in each of the White Sox’s last seven games against NL opponents that held a losing record.
- Sean Burke has recorded a win in three of his last four appearances.
Colorado Rockies Player Prop Facts
- Hunter Goodman has hit at least one home run in three of his last five road appearances against AL Central opponents.
- Tomoyuki Sugano has recorded four or more strikeouts in each of his last four road appearances.
- Connor Norby has recorded at least one hit in each of his last eight appearances with his team as an underdog against AL Central opponents.
- TJ Rumfield ranks 3rd amongst qualified players for On Base Percentage (.388) this season.
Matchup/League Facts
- The White Sox rank 4th in the league for walks this season (584).
- The White Sox rank 5th in the league for runs scored this season (760).
- The Rockies rank 30th in the league for ERA this season (5.59).
- The Rockies rank 30th in the league for strikeouts this season (1092).
White Sox vs Rockies Prediction
There could be a letdown spot for the White Sox after clinching a playoff spot after three straight 100-loss seasons. However, we’ve been on the WHite Sox all season, and there’s no reason to turn back now. The Rockies stink, and Sugano and his 5.36 ERA and 1.33 WHIP don’t make anything better. I’m going to keep backing a team that’s been good to me. Give me the White Sox, and I’ll lay the RL to shave down the price.