White Sox vs Twins Prediction 9/3/25 MLB Picks Today

In this article, we will formulate a White Sox vs Twins Prediction for this MLB game on Wednesday, September 3^rd at the Target Field in the third game of this series, with the White Sox having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 62-76 record this season and are sitting on the 4^th place of the AL Central. The Twins have a 35-34 home record and are 65-64 in over/under. They are coming off a 3-12 home defeat by the White Sox, and are 1-3 in their last 4 games. Over is 11-1 in their last 12 games and are playing the Angels and the Royals next.

The Twins have a .238 batting average this season, .311 OBP and .397 Slugging percentage. Minnesota’s pitching staff has a 4.51 ERA and 1.32 WHIP. Trevor Larnach leads the Twins with 111 hits, while Byron Buxton adds team-highs both in RBI, with 72, and in home runs, with 29. He is also the team’s best hitter with a .272 batting average.

Zebby Matthews (R) is the projected starting pitcher for the Twins, and he has a 4-4 record, 5.06 ERA and 1.48 WHIP.

Chicago White Sox Preview

The Chicago White Sox have a 51-88 record this season and are sitting on the last place of the AL Central. The White Sox have a 21-46 road record and are 65-66 in over/under. They are coming off a 12-3 road victory over the Twins, and have three consecutive wins. Over is 6-2 in their last 8 games and are playing the Rays and the Tigers next.

The White Sox have a .234 batting average this season, .304 OBP and .376 Slugging percentage. Chicago’s pitching staff has a 4.22 ERA and 1.37 WHIP. Lenyn Sosa leads the White Sox with 118 hits, and he is the team’s best hitter with a .265 batting average. He also leads the team in RBI with 62, adding a team-high 19 home runs.

Yoendrys Gomez (R) is the projected starting pitcher for the White Sox, and he has a 3-2 record, 5.20 ERA and 1.54 WHIP.

Why the Minnesota Twins will win

• The White Sox have lost each of their last 10 Wednesday games against AL Central opponents.
• The Twins have won six of their last seven night games against the White Sox following a loss.
• The Twins have covered the run line in six of their last seven night games against the White Sox following a loss.
• The White Sox have failed to cover the run line in four of their last five night games against American League opponents.
• The White Sox have lost the first inning in three of their last four night games.
• The Twins have led after 3 innings in each of their last eight night games against the White Sox at Target Field.
• The Twins have led after 5 innings in three of their last four night games.

Why the Chicago White Sox will win

• The Twins have lost eight of their last nine games as home favorites after playing the previous day.
• The White Sox have won each of their last four games as underdogs against the Twins.
• The White Sox have covered the run line in each of their last eight games following a win.
• The Twins have failed to cover the run line in nine of their last 10 games as home favorites against American League opponents.
• The White Sox have led after 5 innings in three of their last four games against the Twins.
• The Twins have trailed after 3 innings in seven of their last eight games against opponents that held a losing record.

Total Runs Facts

• Each of the Twins’ last eight games have gone OVER the total runs line.
• Each of the White Sox’s last four games against AL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last nine Wednesday games at Target Field.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Twins’ last nine home games.

Matchup/League Facts

• The Twins rank 3rd in the league for walks allowed this season (389).
• The Twins rank 26th in the league for opponent batting average this season (.259).
• The White Sox rank 29th in the league for walks allowed this season (515).
• The White Sox rank 28th in the league for slugging percentage this season (.376).

White Sox vs Twins Prediction

The White Sox are 5-1 in their last 6 head-to-head meetings against the Twins, and both teams are tied 3-3 wins in their last 6 meetings in Minnesota. Over is 8-3-1 in their last 12 meetings.

In this White Sox vs Twins Prediction, the Twins are coming as -180 home favorites. Why on earth are the Twins such big favorites with Zebby Matthews on the mound is beyond me. They have been dominated in this series by the White Sox, getting outscored by 18-8, and Matthews was torched in his only start against the White Sox this season, with 4 earned runs in 4 innings pitched. Gomez’s only start against the Twins this season was a shutout in 4.2 innings pitched, so I really like the White Sox as big road dogs in this one.