White Sox vs Twins Prediction 3/31/25 MLB Picks Today

The Minnesota Twins and the Chicago White Sox meet on Monday in MLB action from Guaranteed Rate Field. This will be the first installment in a three-game early-week series. Here’s a White Sox vs Twins prediction. We will look at this from a betting perspective and determine the best White Sox vs Twins pick.

Minnesota Twins Betting Preview

The Twins played a three-game series versus the Saint Louis Cardinals over the weekend. Minnesota didn’t start out so great, though. In their Thursday opener, the Twins were down 4-0 after just three innings and ended up falling 5-3 and getting out-hit 10-8 along the way. Trevor Larnach (run; walk) and Harrison Bader (two RBI; homer) each had a pair of hits in the defeat. Game two on Saturday was even worse for the Twins. Minnesota was even up three runs in the sixth inning there, posting just three hits in a 5-1 loss. Willi Castro had one of the hits and the team’s lone RBI in a 1-for-3 outing, and starter Joe Ryan logged 5.0 innings with one earned on five hits and no walks alongside five strikeouts.

On Sunday, in the weekend series finale, the Twins gave up three runs in the second inning and five more in the third on the way to a rough loss 9-2. Castro posted a solo homer among his two hits, and Byron Buxton had the other RBI. Starter Bailey Ober coughed up eight earned on eight hits and three walks in 2.2 innings.

In the starting pitcher role for Monday’s game, the Twins are sending out Chris Paddack. Last year, Paddack managed to go 5-3 with a 4.99 ERA in 17 starts. He struck out 79 batters in 88.1 innings of work. In his regular-season career, Paddack is 27-24 with a 4.38 ERA in 85 games (82 starts). He’s got 417 Ks in 423.2 innings total.

Chicago White Sox Betting Preview

Over on the White Sox’s side, they’re coming off a pretty competitive series versus the Los Angeles Angels. Chicago didn’t have a ton of difficulty in their Thursday opener, posting five runs in the eighth inning on the way to an 8-1 blowout victory. Andrew Benintendi (three RBI), Austin Slader, and Lenyn Sosa (two RBI) each had home runs in the win. In game two on Saturday, the Sox bats quieted down significantly. Chicago posted just two hits in a 1-0 loss. Benintendi had one, as did Brooks Baldwin. Starter Jonathan Cannon posted a solid outing with 5.0 clean frames, four hits, and three walks.

In the Sunday rubber match, the White Sox sat through a lengthy rain delay in the seventh. When the skies cleared, Chicago ended up falling 3-2. Starter Davis Martin finished with 6.0 clean frames, four hits, two walks, and two Ks.

It’ll be Martin Perez in the starting pitcher role for the Sox on Monday. Last season, Perez managed to go 5-6 with a 4.53 ERA in 26 starts, striking out 107 batters over 135.0 innings. Perez is 90-87 with a 4.44 ERA in 314 career games (269 starts). He’s got 1109 total strikeouts across 1575.2 innings of work. The White Sox will meet the Tigers after this series.

Why the Chicago White Sox will win

• The Twins have lost each of their last seven games as favorites.
• The underdogs have won 10 of the Twins’ last 11 games.
• The White Sox have covered the run line in each of their last eight games at Rate Field.
• The Twins have failed to cover the run line in 14 of their last 15 games as road favorites.
• The Twins have trailed after 5 innings in each of their last six games against American League opponents.
• The Twins have trailed after 3 innings in four of their last five road day games.

Why the Minnesota Twins will win

• The White Sox have lost each of their last 11 home games against AL Central opponents.
• The Twins have won each of their last nine games as favorites against the White Sox following a road loss.
• The White Sox have failed to cover the run line in each of their last eight games as home underdogs against AL Central opponents.
• The Twins have covered the run line in seven of their last eight day games against the White Sox following a loss.
• The Twins have led after 5 innings in each of their last six games against AL Central opponents that held a losing record.
• The Twins have led after 3 innings in each of their last six games against AL Central opponents that held a losing record.

Total Runs Facts

• Each of the White Sox’s last four home games after playing the previous day have gone UNDER the total runs line.
• Five of the Twins’ last six games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last nine Monday games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Twins’ last six day games.

White Sox vs Twins Prediction

I’ll lean toward taking a stab on the Sox. Perez had a nice spring this year, notching a 2-1 record and a 2.25 ERA in five starts. He gave up 15 hits in 16.0 total innings. If Perez can continue to keep the damage minimal on Monday, Chicago will be in good shape. As for Paddack, he started five games in Spring Training, taking a 1-0 record with a 4.58 ERA along with 17 hits in 17.2 innings of work total. We should have a nice pitching matchup here if both guys are on point.

On Sunday, Chicago couldn’t find any life after the rain delay and posted a pretty lethargic defeat. The Sox did come up with seven team hits and a solo homer from Nick Maton, but it wasn’t enough. I like them to improve on Monday, and maybe bag the win.