White Sox vs Twins Prediction 4/2/25 MLB Picks Today

In this article, we will formulate a White Sox vs Twins prediction for this MLB game on Wednesday, April 2, at  Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Betting Preview

The Minnesota Twins (1-4, 1-4 Away) were swept by the St. Louis Cardinals in a three-game series to open a new season before suffering a massive 9-0 loss in the opening game of a three-game series with the Chicago White Sox. The Twins managed to avoid the fifth consecutive defeat with an 8-3 win in Game 2. Harrison Bader recorded a home run and three RBI, while Louis Varland got a win.

This season, the Twins average 1.50 runs per game (30th in the MLB) on a .143/.206/.230 slash line. Regarding pitching, the Twins’ staff has a 7.31 ERA (29th) and 1.72 WHIP (29th). Harrison Bader leads the Twins with a .250 batting average, two home runs, and five RBI this season.

The projected starting pitcher for the Twins is Pablo Lopez, who had a 15-10 record in 32 starts last season with a 4.08 ERA and 1.19 WHIP over 185.1 innings of work. Lopez took a loss against the Cards this year and posted a 3.60 ERA in 5.0 innings.

Chicago White Sox Betting Preview

The Chicago White Sox (2-3, 2-3 Home) lost the first series of the season 2-1 to the Los Angeles Angels and opened this series with a comfortable 9-0 victory over the Minnesota Twins. However, the Twins bounced back with an 8-3 win in Game 2. Brooks Baldwin contributed a pair of RBIs, while Penn Murfee took a loss after allowing three runs on four hits, without even getting a single out.

This year, the White Sox average 4.75 runs per game (13th in the MLB) on a .210/.283/.411 triple-slash. When it comes to pitching, the White Sox’ staff has a 0.75 ERA (1st) and 0.91 WHIP (3rd). Andrew Benintendi leads the White Sox with a .353 batting average, two home runs, and six RBI this season.

Sean Burke will take the mound for the White Sox on Wednesday. The 25-year-old righty had a 2-0 record last season in three starts with a 1.42 ERA and 1.00 WHIP in 19.0 innings. This season, Burke started with a win in a shutout of the Angels when he allowed just three hits with three strikeouts over 6.0 innings of work. The White Sox will meet the Tigers after this series.

Why the Twins will beat the White Sox

• The White Sox have lost 11 of their last 12 day games following a home loss.
• The Twins have won 10 of their last 11 games against the White Sox following a win.
• The White Sox have failed to cover the run line in nine of their last 10 home games against AL Central opponents.
• The Twins have covered the run line in four of their last five games against AL Central opponents that held a losing record.

Why the White Sox will beat the Twins

• The Twins have lost each of their last four games as favorites following a win.
• The White Sox have won three of their last four games as underdogs following a loss.
• The White Sox have covered the run line each of their last six day games against teams that held a losing record.
• The Twins have failed to cover the run line in nine of their last 10 day games against American League opponents.
• The White Sox have led after 5 innings in each of their last four day games against the Twins at Rate Field.
• The White Sox have won the first inning in three of their last four home games against AL Central opponents that held a losing record.
• The Twins have trailed after 3 innings in five of their last six road day games.

Total Runs Facts

• Each of the Twins’ last four road games against American League opponents have gone OVER the total runs line.
• Four of the White Sox’s last five games as underdogs against the Twins have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 14 of the White Sox’s last 16 games as underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Twins’ last seven day games.

White Sox vs Twins Prediction

The Twins won eight of the previous ten H2H encounters, including five of the last six. Sean Burke had a fantastic start to the season, but after allowing no runs against the Angels, I think he will have more trouble on Wednesday. Willi Castro and Harrison Bader are the ones to look at. On the other hand, Pablo Lopez faced the White Sox on two occasions last year and posted a 5.00 ERA in 9.0 innings. He should be worried when Benintendi is on the plate. Seven of the last ten H2Hs went Over, and I am backing Over in this one as well.