White Sox vs Twins Prediction 8/22/25 MLB Picks Today

The Minnesota Twins and Chicago White Sox meet Friday in MLB action at Rate Field. Here’s a White Sox vs Twins Prediction. This article will include a White Sox vs Twins Pick.

Minnesota Twins Betting Preview

The Minnesota Twins are 58-69 on the year and play the Blue Jays, Padres, and White Sox next. The Minnesota Twins are batting .237 on the season, have a .309 OBP, and a .395 slugging percentage. The Minnesota Twins pitching staff has a 4.25 ERA and a 1.28 WHIP. Byron Buxton leads the Minnesota Twins with 99 hits and 61 RBI, while Trevor Larnach and Brooks Lee have combined for 192 hits and 103 RBI.

Zebby Matthews gets the ball for the Minnesota Twins, and he is 3-4 with a 5.06 ERA and 63 strikeouts this season. This will be Matthews’ first career game against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 45-82 on the year and play the Royals, Yankees, and Twins next. The Chicago White Sox are batting .231 on the season, have a .301 OBP, and a .370 slugging percentage. The Chicago White Sox pitching staff has a 4.18 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 108 hits and 55 RBI while Miguel Vargas and Chase Meidroth have combined for 181 hits and 62 RBI.

Aaron Civale gets the ball for the Chicago White Sox, and he is 3-8 with a 4.88 ERA and 65 strikeouts this season. Civale is 1-4 with a 4.34 ERA and 61 strikeouts in his career against the Minnesota Twins.

Why the Chicago White Sox will win

• The Twins have lost seven of their last eight games as favorites after playing the previous day.
• The underdogs have won four of the Twins’ last five games.
• The Twins have failed to cover the run line in 10 of their last 11 night games against teams that held a losing record.
• The White Sox have covered the run line in nine of their last 10 night games against teams that held a losing record.
• The Twins have trailed after 3 innings in eight of their last nine night games against American League opponents.
• The White Sox have led after 5 innings in four of their last five games against the Twins at Rate Field.

Why the Minnesota Twins will win

• The White Sox have lost each of their last 11 night games against AL Central opponents following a road loss.
• The Twins have won eight of their last nine games against the White Sox following a loss.
• The Twins have covered the run line in seven of their last eight road games following a loss.
• The White Sox have failed to cover the run line in seven of their last eight games against the Twins following a road loss.
• The Twins have won the first inning in each of their last four road games against AL Central opponents.
• The White Sox have trailed after 3 innings in four of their last five night games against AL Central opponents that held a losing record.
• The Twins have led after 5 innings in each of their last seven Friday games against AL Central opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Luis Robert has hit a home run in two of his last three appearances after not playing the previous day.
• Aaron Civale has recorded six or more strikeouts in four of his last five appearances.
• Luis Robert has recorded at least one hit in 15 of his last 16 appearances against opponents that held a losing record.
• Luis Robert ranks T6th in the league in Steals (31) this season.

Minnesota Twins Player Prop Facts

• Trevor Larnach has hit a home run in each of his last three road appearances after playing the previous day.
• Trevor Larnach has recorded at least one hit in each of his last seven appearances with the Twins as favorites against AL opponents.
• Byron Buxton has recorded at least one Double in three of his last four appearances at Rate Field against opponents that held a losing record.
• Byron Buxton ranks 10th amongst qualified players for Slugging Percentage (.538) this season.

White Sox vs Twins Prediction

I’m not running to the window to back either side, as the White Sox are possibly the worst franchise in MLB, while the Twins are one of the most disappointing teams this season. Matthews has a 5.06 ERA and 1.44 WHIP on the season, and he has a 5.46 ERA and .283 allowed batting average on the road. Civale has allowed 17 hits and 12 runs in his last 15.2 innings, and he has a 6.25 ERA and .258 allowed batting average at home. Two bad teams but two rough pitchers in terrible form. This could be an offensive shootout. I’ll grab the over if forced to pick.