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White Sox vs Twins Prediction 9/5/26 MLB Picks Today

Minnesota Twins (67-74) vs. Chicago White Sox (74-67)
September 5, 2026 7:10 pm EDT
The Line: Chicago White Sox -122 / Minnesota Twins 101; Over/Under: 8
(Get latest betting odds)

In this article we will formulate a White Sox vs Twins prediction for this MLB game on Saturday, September 5th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 74-67 this season after they won game one by a score of 4-1 on Friday night. Chicago did all of their damage in the first four innings and they were able to get the lower scoring win. The White Sox recorded six hits and they committed one error in the game, while they were led by Montgomery, who went 1-4 with one home run and two RBIs. Fedde allowed three hits and zero earned runs over 5.0 innings for the win, while Taylor allowed one earned run in relief. Prior to this series, Chicago lost three out of four against the Astros, but did win two out of three against the Twins before that. 

This season, Chicago has a 4.12 ERA with a 1.31 WHIP and a .240 opponent batting average, while they have scored 667 runs with a .236 batting average and a .318 on base percentage. Colson Montgomery has led the White Sox with 30 home runs and 81 RBIs, while Miguel Vargas has added 30 home runs and 77 RBIs. The projected starting pitcher for Chicago is Anthony Kay, who is 9-7 with a 4.28 ERA and a 1.35 WHIP over 136.2 innings pitched this season. 

Minnesota Twins Betting Preview

The Minnesota Twins are 67-74 this year after they lost game one by a score of 1-4 on Friday night. Minnesota had plenty of baserunners, but didn’t score until the ninth in the loss. The Twins recorded eight hits in the game and they were led by Bell, who went 2-3 with one home run and one RBI. Matthews allowed four hits and four earned runs over 5.0 innings for the loss, while Acton threw two innings in relief. Prior to this series, Minnesota won two out of three against the Tigers, but lost two out of three against the White Sox before that. 

This season, Minnesota has a 4.63 ERA with a 1.37 WHIP and a .251 opponent batting average, while they have scored 659 runs with a .246 batting average and a .320 on base percentage. Byron Buxton has led the Twins with 25 home runs and 46 RBIs, while Josh Bell has added 18 home runs and 84 RBIs. The projected starting pitcher for Minnesota is Taj Bradley, who is 10-6 with a 3.85 ERA and a 1.26 WHIP over 154.1 innings pitched this year. 

Why the Chicago White Sox will win

  • The Twins have lost each of their last six road games against teams that held a winning record.
  • The White Sox have won eight of their last nine games against AL Central opponents.
  • The favorites have covered the run line in each of the White Sox’s last six games.
  • The Twins have failed to cover the run line in each of their last four games as underdogs.
  • The Twins have trailed after 3 innings in seven of their last eight games at Rate Field.
  • The White Sox have won the first inning in each of their last three night games against AL Central opponents.
  • The Twins have trailed after 5 innings in six of their last seven games at Rate Field.

Why the Minnesota Twins will win

  • The Twins have won each of their last six Saturday night games as road underdogs against AL opponents.
  • The White Sox have lost three of their last four games as favorites following a win.
  • The Twins have covered the run line in each of their last eight Saturday night games as road underdogs against AL opponents.
  • The White Sox have failed to cover the run line in each of their last four games as favorites against AL Central opponents following a win.
  • The Twins have led after 3 innings in each of their last five Saturday night road games.

Total Runs Facts

  • Seven of the Twins’ last eight games as underdogs against AL Central opponents have gone UNDER the total runs line.
  • Each of the White Sox’s last four games have gone UNDER the total runs line.
  • There has been at least one run scored in the first inning in eight of the last nine games between the Twins and White Sox.
  • There has been at least one run scored in the first inning in seven of the Twins’ last eight games.

Chicago White Sox Player Prop Facts

  • Braden Montgomery has recorded at least one hit in each of the White Sox’s last 11 night games against AL opponents that held a losing record.
  • Tristan Peters has hit a home run in five of the White Sox’s last six home games.
  • Anthony Kay has recorded a win in four of his last five home appearances against AL Central opponents that held a losing record.

Minnesota Twins Player Prop Facts

  • Josh Bell has recorded at least one hit in each of the Twins’ last nine night games against AL Central opponents that held a winning record.
  • Kody Clemens has hit a home run in three of the Twins’ last five night games.
  • Taj Bradley has recorded seven or more strikeouts in seven of his last eight appearances in night games.

Matchup/League Facts

  • The White Sox rank 6th in the league for runs scored this season (662).
  • The White Sox rank 6th in the league for home runs this season (181).
  • The Twins rank 27th in the league for runs allowed this season (696).
  • The Twins rank 25th in the league for ERA this season (4.63).

White Sox vs Twins Prediction 

Chicago was able to get a much needed win in game one on Friday night and they have allowed two runs or fewer in three of their last four games. The White Sox are 42-27 at home this year, while the Twins are 29-40 on the road. Minnesota has lost two in a row, but they have scored 5+ runs in four of their last five. The Twins are starting Bradley, who has allowed 1, 4, 1, 5, and 3 earned runs in his last five starts, while Kay has allowed nine earned runs in his last 9.1 innings. Take the over here. 

David Racey's Free Pick: Over 8

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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