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Yankees vs Cardinals Prediction 8/5/26 MLB Picks Today

St. Louis Cardinals (56-58) vs. NY Yankees (64-50)
August 5, 2026 7:05 pm EDT
The Line: NY Yankees -156 / St. Louis Cardinals 129; Over/Under: 8.5
(Get latest betting odds)

The St. Louis Cardinals and New York Yankees meet Wednesday in MLB action at Yankee Stadium. Here’s a Yankees vs Cardinals Prediction. This article will include a Yankees vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 56-58 on the year and play the Phillies and Rockies next. The St. Louis Cardinals are batting .239 on the season, with a .315 OBP and a .379 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.15 ERA and a 1.34 WHIP. Alec Burleson leads the St. Louis Cardinals with 124 hits and 77 RBI, while Jordan Walker and JJ Wetherholt have combined for 227 hits and 122 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 11-6 with a 3.72 ERA and 86 strikeouts this season. Pallante is 1-1 with a 3.72 ERA and 10 strikeouts in his career against the New York Yankees.

New York Yankees Betting Preview

The New York Yankees are 64-50 on the year and play the Braves and Mariners next. The New York Yankees are batting .232 on the season, with a .309 OBP and a .413 slugging percentage. The New York Yankees’ pitching staff has a 3.34 ERA and a 1.19 WHIP. Ben Rice leads the New York Yankees with 106 hits and 73 RBI, while Cody Bellinger and Jazz Chisholm Jr. have combined for 179 hits and 99 RBI.

Will Warren gets the ball for the New York Yankees, and he is 8-5 with a 4.14 ERA and 109 strikeouts this season. Warren is 0-1 with a 5.19 ERA and 6 strikeouts in his career against the St. Louis Cardinals.

Why the New York Yankees will win

  • The Cardinals have lost eight of their last nine games against AL East opponents that held a winning record.
  • The Yankees have won four of their last five games against the Cardinals.
  • The Cardinals have failed to cover the run line in seven of their last eight night games following a loss.
  • The Yankees have covered the run line in four of their last five night games following a home win.
  • The Yankees have led after 3 innings in nine of their last 11 home games against National League opponents that held a losing record.
  • The Cardinals have trailed after 5 innings in seven of their last eight night games against AL East opponents that held a winning record.

Why the St. Louis Cardinals will win

  • The Cardinals have won each of their last six Wednesday games as underdogs against AL East opponents.
  • The Yankees have lost five of their last six games as home favorites following a win.
  • The Yankees have failed to cover the run line in each of their last five games following a win.
  • The Cardinals have covered the run line in each of their last six Wednesday games as underdogs against AL East opponents.
  • The Yankees have trailed after 3 innings in six of their last eight games against opponents that held a losing record.
  • The Yankees have trailed after 5 innings in 10 of their last 12 games against opponents that held a losing record.
  • The Yankees have lost the first inning in four of their last five night games against National League opponents.

Total Runs Facts

  • Seven of the Cardinals’ last eight road games have gone UNDER the total runs line.
  • Five of the last six games between the Cardinals and Yankees at Yankee Stadium have gone OVER the total runs line.
  • There has been no run scored during the first inning in six of the Cardinals’ last seven games.
  • There has been no run scored during the first inning in five of the last six games between the Cardinals and Yankees at Yankee Stadium.

New York Yankees Player Prop Facts

  • Luis Garcia has hit at least one home run in three of his last four appearances with his team as a favorite against NL Central opponents.
  • Will Warren has recorded five or more strikeouts in 13 of his last 14 home appearances against opponents that held a losing record.
  • Jose Caballero has recorded at least one hit in each of his eight previous appearances against the Cardinals.
  • Jazz Chisholm ranks T2nd in the league in Steals (30) this season.

St. Louis Cardinals Player Prop Facts

  • Jimmy Crooks has hit a home run in each of his last two road appearances against opponents that held a winning record.
  • Andre Pallante has recorded five or more strikeouts in four of his last five appearances against AL opponents.
  • Jordan Walker has recorded at least one hit in each of his last nine appearances with the Cardinals as road underdogs against AL East opponents.
  • Andre Pallante has recorded a win in six of his last seven road appearances.
  • Alec Burleson ranks 7th in the league in Hits (124) this season.

Matchup/League Facts

  • The Yankees rank 1st in the league for ERA this season (3.34).
  • The Yankees rank 2nd in the league for home runs this season (164).
  • The Cardinals rank T27th in the league for doubles this season (154).
  • The Cardinals rank 27th in the league for slugging percentage this season (.379).

Yankees vs Cardinals Prediction

The Yankees should be favored at home, but we’re getting plus money with a Cardinals team that’s been good at home. Warren is also coming off a rough July where he allowed 27 hits and 15 runs in 24.2 innings. Pallante is coming off a July where he allowed 27 hits and 11 runs in 29.1 innings. On the road through 44 frames, Pallante has a 2.66 ERA and a .186 batting average allowed. There’s value with the Cards and the more favorable price. I’ll take it.

Randy Chambers's Free Pick: St. Louis Cardinals 129

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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