Yankees vs Giants Prediction 4/12/25 MLB Picks Today

The San Francisco Giants and the New York Yankees meet Saturday in MLB action from Yankee Stadium. This will be the second installment in a three-game weekend series. Here’s a Yankees vs Giants prediction. We will look at this from a betting perspective and determine the best Yankees vs Giants pick.

San Francisco Giants Betting Preview

The Giants’ season began with a matchup versus the Cincinnati Reds. San Francisco took two of three in that one for a series victory, then swept the Houston Astros in the next set. San Francisco kept it going with three straight wins over the Seattle Mariners, but then suffered their first series loss of the year against the Cincinnati Reds. The Giants fell 2-0 and 1-0 before salvaging an 8-6 win on Wednesday to prevent getting swept themselves. In that victory over Cincinnati, the Giants gave up five runs in the third and faced a 6-1 deficit at one point but clawed back for the walk-off victory in 10 innings.

On Friday in the opener versus the Yankees, San Francisco bagged five runs in the first inning along the way to a 9-1 blowout win. The game was called off after just six innings due to bad weather. Starter Robbie Ray lasted 4.0 innings with one earned run on two hits and four walks along with seven strikeouts.

In the Saturday game two starting pitcher job, the Giants will send out Jordan Hicks. This year Hicks is 1-0 with a 2.38 ERA in his two starts and 11.1 innings total. Hicks is 16-28 with a 3.88 ERA in 243 career games (30 starts). He’s also got 33 saves to his credit in that time.

New York Yankees Betting Preview

Over on the Yankees’ side, they opened up their year with an impressive sweep over the Milwaukee Brewers, scoring 36 runs in three games. New York was nearly swept by the Arizona Diamondbacks in the next set, losing two of three. In their matchup versus the Pittsburgh Pirates, the Yankees won two of three themselves, then nearly got swept by the Tigers in the next series. The lone win in that set was a 4-3 result on Wednesday.

In the Friday game the Yankees put up just two hits in the shortened loss. Marcus Stroman put up five earned runs in just 0.2 innings on four hits and three walks as starting pitcher.

It’ll be Will Warren in the starting pitcher role for the Yankees on Saturday. This year over his two starts Warren has a 6.00 ERA without a decision. He’s got nine Ks in 9.0 innings. Over his career Warren is 0-3 with a 9.09 ERA in eight games (seven starts).

Why the New York Yankees will win

• The Yankees have won each of their last 11 day games against NL West opponents following a loss.
• The Giants have lost seven of their last eight day games against AL East opponents following a win.
• The Giants have failed to cover the run line in each of their last seven day games against AL East opponents following a win.
• The Yankees have covered the run line in seven of their last eight day games against NL West opponents following a home loss.
• The Yankees have led after 5 innings in five of their last six day games against National League opponents.
• The Yankees have led after 3 innings in seven of their last eight home day games.
• The Yankees have won the first inning in each of their last four day games at Yankee Stadium.

Why the San Francisco Giants will win

• The Giants have won each of their last 10 games against American League opponents.
• The Yankees have lost three of their last four games as favorites.
• The Giants have covered the run line in 15 of their last 16 games as underdogs against American League opponents.
• The Yankees have failed to cover the run line in each of their last five games.
• The Giants have led after 5 innings in each of their last 10 games against American League opponents.
• The Giants have led after 3 innings in each of their last seven road games against American League opponents.
• The Giants have won the first inning in nine of their last 12 games as underdogs against American League opponents.

Total Runs Facts

• Each of the Giants’ last six games against AL East opponents have gone OVER the total runs line.
• Eight of the Yankees’ last nine games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Yankees’ last 10 games as home favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Giants’ last six games against AL East opponents.

Yankees vs Giants Prediction

I’m staying with the Giants. Hicks had a nice debut this season, notching a victory over the Astros on March 31 with 6.0 clean frames, one hit and two walks. Start number two wasn’t as smooth: a no-decision versus the Seattle Mariners with 5.1 innings, three earned, six hits and a walk. As for Warren, he’s coming off a rough outing in a no-decision versus Pittsburgh on April 6. In that one Warren put up four earned runs on six hits and a walk in 4.0 innings total. San Francisco should be able to notch a few runs in the early-going Saturday if all goes well.

On Friday the Giants got right to work in the first inning and asserted their dominance on the road. San Francisco should be in a nice position to win the series here as the Yankees wilt in cold weather among myriad issues on both sides of the ball.