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Yankees vs Orioles Prediction 9/26/25 MLB Picks Today

Baltimore Orioles (75-84) vs. NY Yankees (91-68)
September 26, 2025 7:05 pm EDT
The Line: NY Yankees -157 / Baltimore Orioles 128; Over/Under: 8
(Get latest betting odds)

The New York Yankees and Baltimore Orioles meet on Friday in MLB action from Yankee Stadium. Here’s a Yankees vs Orioles prediction. We will look at this from a betting perspective and determine the best Yankees vs Orioles pick. 

Can Orioles Finish Season on High Note?

The Orioles’ season has been filled with mostly disappointment, but maybe they can finish the season on a high note with some success against the Yankees. The Orioles in the last game faced off against the Tampa Bay Rays, and on Thursday, they secured a 6-5 victory. Ryan Mountcastle hit a home run and drove in two RBIs. Dylan Beavers hit a home run also, and they need to hit a few home runs. 

The Orioles are averaging 4.21 runs while their pitching is giving up 4.85 runs per game. The offense is ranked 23rd, while the pitching is ranked 25th. Jackson Holliday has hit 17 home runs and driven in 55 RBIs. Getting the start for the Orioles will be Trevor Rogers who sits with a 9-2 record and an ERA of 1.35. In his last start against the New York Yankees, he went six innings giving up one hit and zero runs. 

Another Win for the Yankees

The Yankees hopes are still alive to win the AL East, but it might take a sweep against Baltimore to get that done. On Thursday, the Yankees faced off against the Chicago White Sox, and it wasn’t the most dominant game, but they secured the 5-3 victory. The Yankees scored three runs in the 5th inning, and that was enough to pick up the victory. Gincarlo Stanton had a huge game finishing with one hit and three runs driven in. Carlos Rodon went six innings giving up four hits and three runs. 

The Yankees are averaging 5.24 runs while their pitching is giving up 4.27 runs per game. The offense is ranked 1st in all of baseball while the pitching is ranked 15th. They have a positive run differential of 0.96 which is 2nd in the league. Aaron Judge has hit 51 home runs and driven in 109 RBIs. Getting the start for the Yankees will be Will Warren who sits with an 8-8 record and an ERA of 4.35. Against the Baltimore Orioles he went 5.1 innings giving up four hits and only one earned run. 

Yankees vs Orioles prediction

The Yankees need this win, but the problem is that Trevor Rogers is on the mound on the other side. Rogers sits with a 9-2 record and in his last start he went six innings giving up only one hit and zero runs. I know Will Warren was good in his last start, but unless he’s having a shoutout here, this game is going to be over early. The Orioles might only score three or four runs, and the Yankees are going to have zero answer. The Yankees might be tempting to many, but I am just not betting against Rogers. Back the Orioles on the money line. 

Shane Mickle's Free Pick: Orioles ML +128

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Shane Mickle

Sports is about all Shane knows in this life! He has a passion for sports and writing, which makes working for Sportschatplace a perfect job for him! If you find him cheering for a team it's usually a Minnesota team, or the Kansas Jayhawks!

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