Yankees vs Orioles Prediction 9/27/25 MLB Picks Today

In this article we will formulate a Yankees vs Orioles prediction for this MLB game on Saturday, September 27th at Yankee Stadium in New York. Let’s take a look at the prediction for this MLB matchup. 

New York Yankees Betting Preview

The New York Yankees are 92-68 this year after they won game one by a score of 8-4 on Friday night. New York had their lead cut to 6-4 in the sixth inning, but they added two insurance runs to seal the victory. The Yankees recorded nine hits and they committed one error in the game, while they were led by Stanton, who went 2-4 with two home runs and five RBIs in the win. New York started Warren, who allowed six hits and four earned runs over 5.0 innings for the win, while five pitchers combined for the last 4.0 innings. 

Prior to this series, the Yankees swept the White Sox in three games and won three out of four against the Orioles. New York has won six games in a row and they are second in the AL East standings. The New York pitching staff has a 3.94 ERA with a 1.25 WHIP and a .230 opponent batting average, while the offense has scored 840 runs with a .251 batting average and a .332 on base percentage this season. Aaron Judge has led New York with 52 home runs and 111 RBIs, while Cody Bellinger has added 29 home runs and 97 RBIs this year. The projected starting pitcher for New York is Cam Schlittler, who is 3-3 with a 3.27 ERA and a 1.30 WHIP over 66.0 innings pitched this year. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 75-85 this season after they lost game one by a score of 8-4 on Friday night. Baltimore took a 3-2 lead in the third inning, but only scored one more run in the last six innings for the loss. The Orioles recorded seven hits and they committed one error in the game, while they were led by Westburg, who went 3-5 with one home run and three RBIs in the loss. Baltimore started Rogers, who allowed three hits and six earned runs in 3.0 innings for the loss, while Cano allowed two earned runs in relief. 

Prior to this series, the Orioles won two out of three against the Rays, but lost three out of four against the Yankees before that. Baltimore has lost four of their last six games and they are last in the AL East standings. The Baltimore pitching staff has a 4.60 ERA with a 1.37 WHIP and a .260 opponent batting average, while their offense has scored 674 runs with a .236 batting average and a .305 on base percentage this season. Jackson Holliday has led Baltimore with 17 home runs and 55 RBIs, while Gunnar Henderson has added 16 home runs and 67 RBIs this year. The projected starting pitcher for Baltimore is Tomoyuki Sugano, who is 10-9 with a 4.54 ERA and a 1.34 WHIP over 152.2 innings pitched this season. 

Why the Yankees will beat the Orioles

• The Yankees have won each of their last seven home games against teams that held a losing record.
• The Orioles have lost each of their last eight Saturday games against American League opponents.
• The Yankees have covered the run line in nine of their last 10 games against AL East opponents that held a losing record.
• The Orioles have failed to cover the run line in five of their last six games against teams that held a winning record.
• The Yankees have led after 5 innings in each of their last seven home games against opponents that held a losing record.
• The Yankees have won the first inning in six of their last eight games as favorites against AL East opponents.
• The Yankees have led after 3 innings in 11 of their last 12 home games against opponents that held a losing record.

Why the Orioles will beat the Yankees

• The Orioles have won eight of their last 10 games as underdogs against the Yankees following a road loss.
• The Yankees have lost eight of their last 11 games as favorites against the Orioles following a home win.
• The Orioles have covered the run line in eight of their last nine day games following a road loss.
• The Yankees have failed to cover the run line in five of their last six games as home favorites against AL East opponents following a win.
• The Orioles have led after 5 innings in six of their last eight day games against AL East opponents that held a winning record.
• The Orioles have led after 3 innings in three of their last four road day games.

Total Runs Facts

• Nine of the Yankees’ last 10 games as favorites against AL East opponents have gone UNDER the total runs line.
• Seven of the Orioles’ last eight games as underdogs against the Yankees have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last six day games at Yankee Stadium.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last four games between the Orioles and Yankees at Yankee Stadium.

New York Yankees Player Prop Facts

• Aaron Judge has hit a home run in six of the Yankees’ last eight home games against the Orioles.
• Giancarlo Stanton has recorded at least one hit in each of his last six home appearances against the Orioles after playing the previous day.

Baltimore Orioles Player Prop Facts

• Tyler O’Neill has hit a home run in each of his last two road appearances against the Yankees.
• Colton Cowser has recorded a Double in three of his last four appearances against the Yankees.
• Ryan Mountcastle has recorded at least one hit in each of his last 12 road appearances against the Yankees.

Yankees vs Orioles Prediction 

New York picked up another win to start this series on Friday and they continue to play great baseball over the last few weeks. The Yankees are 48-31 at home this year, while the Orioles are 36-43 on the road. Baltimore is starting Sugano, who has allowed 3+ earned runs in four of his last five starts. New York is going with Schlittler, who has allowed 1, 4, 1, 4, and 1 earned run in his last five outings. Take the over here.