Yankees vs White Sox Prediction 9/23/25 MLB Picks Today

In this article we will formulate a Yankees vs White Sox prediction for this MLB game on Tuesday, September 23rd at Yankee Stadium in New York. Let’s take a look at the prediction for this MLB matchup. 

New York Yankees Betting Preview

The New York Yankees are 88-68 this season after they won three out of four against Baltimore by scores of 7-0, 2-4, 6-1, and 7-1. In their game four win, New York tied the game at one in the sixth inning and scored six runs in the 10th for the victory. The Yankees recorded 10 hits in the game and they were led by Rice, who went 4-5 with one home run and five RBIs in the win. New York started Schlittler, who allowed three hits and one earned run over 5.1 innings, while Bednar picked up the win. 

Prior to that series, the Yankees won two out of three against the Twins and two out of three against the Red Sox. New York has won five of their last six games and they are currently second in the AL East standings. The New York pitching staff has a 3.97 ERA with a 1.26 WHIP and a .231 opponent batting average, while the offense has scored 816 runs with a .250 batting average and a .330 on base percentage this season. Aaron Judge has led New York with 49 home runs and 105 RBIs, while Cody Bellinger has added 29 home runs and 97 RBIs this year. The projected starting pitcher for New York is Luis Gil, who is 4-1 with a 3.33 ERA and a 1.50 WHIP over 46.0 innings pitched this season. 

Chicago White Sox Betting Preview

The Chicago White Sox are 58-98 this year after they lost two out of three against the Padres by scores of 4-3, 3-7, and 2-3. In their game three loss, Chicago cut the deficit to 3-2 in the seventh inning, but couldn’t find the tying run in the defeat. The White Sox recorded five hits and they committed two errors in the game, while they were led by Benintendi and Vargas, who both had one RBI in the loss. Chicago started Burke, who allowed six hits and two earned runs over 4.0 innings for the loss, while four pitchers combined to close out the game. 

Prior to that series, the White Sox lost all three against the Orioles and all three against the Guardians. Chicago has lost eight of their last nine games and they are last in the AL Central standings. The Chicago pitching staff has a 4.23 ERA with a 1.36 WHIP and a .247 opponent batting average, while the offense has scored 618 runs with a .232 batting average and a .302 on base percentage this season. Lenyn Sosa has led Chicago with 21 home runs and 71 RBIs, while Andrew Benintendi has added 20 home runs and 63 RBIs this year. The projected starting pitcher for Chicago is Shane Smith, who is 6-8 with a 4.06 ERA and a 1.22 WHIP over 135.1 innings pitched this year. 

Why the Yankees will beat the White Sox

• The Yankees have won 21 of their last 22 night games against AL Central opponents following a road win.
• The White Sox have lost each of their last six games against American League opponents.
• The Yankees have covered the run line in seven of their last eight home games against teams that held a losing record.
• The White Sox have failed to cover the run line in seven of their last eight night games against American League opponents that held a winning record.
• The Yankees have led after 3 innings in each of their last eight home games against opponents that held a losing record.
• The Yankees have led after 5 innings in seven of their last eight home games against opponents that held a losing record.
• The Yankees have won the first inning in four of their last five games against the White Sox.

Total Runs Facts

• Each of the White Sox’s last six games as underdogs against American League opponents have gone UNDER the total runs line.
• Each of the Yankees’ last four games have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last seven games against AL East opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the last 15 night games between the White Sox and Yankees at Yankee Stadium.

New York Yankees Player Prop Facts

• Giancarlo Stanton has hit a home run in four of his last five home appearances against opponents that held a losing record.
• Anthony Volpe has recorded at least one hit in each of his last 12 appearances against AL Central opponents that held a losing record.
• Paul Goldschmidt has recorded a Double in four of his last five home appearances against opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Luis Robert has recorded at least one hit in 15 of his last 16 road appearances.
• Andrew Benintendi has hit a home run in two of his last three appearances against AL East opponents.

Yankees vs White Sox Prediction 

New York enters the last week of the regular season trying to catch the Blue Jays in the East, so they have to take advantage of playing Chicago here. The Yankees are 44-31 at home this year, while the White Sox are 25-50 on the road. Chicago has really dropped their level of play in the last few weeks and they are starting Smith, who has allowed 4+ earned runs in two of his last three outings. NY is going with Gil, who has allowed two earned runs or fewer in four of his last five. I expect New York to jump all over the White Sox in this game and I like them to win by at least two runs.