Celtics vs 76ers Prediction 4/21/26 NBA Picks Today
Philadelphia 76ers (45-37) vs. Boston Celtics (56-26)
April 21, 2026 7:00 pm EDT
The Line: Boston Celtics -13.5; Over/Under: 216.5
(Get latest betting odds)
The Philadelphia 76ers and Boston Celtics meet Tuesday in NBA Game 2 at the TD Garden. Here’s a Celtics vs. 76ers Prediction. This article will include a Celtics vs. 76ers Pick.
Philadelphia 76ers Betting Preview
The Philadelphia 76ers need a win to even up the series at 1-1. The 76ers have won 7 of their last 12 games.
The Philadelphia 76ers are averaging 91 points on 38.9 percent shooting and allowing 123 points on 50 percent shooting. Tyrese Maxey is averaging 21 points and 8 assists, while Paul George is averaging 17 points and 4 rebounds. VJ Edgecombe is the third double-digit scorer, and Kelly Oubre Jr. is grabbing 7 rebounds. The Philadelphia 76ers are shooting 17.4 percent from beyond the arc and 73.9 percent from the free-throw line. The Philadelphia 76ers are allowing 44 percent shooting from deep and are grabbing 40 rebounds per game. Check out another game on Tuesday night between the Spurs and Trail Blazers.
Boston Celtics Betting Preview
The Boston Celtics look for another win to take a 2-0 series lead. The Celtics have won 32 of their last 43 games.
The Boston Celtics are averaging 123 points on 50 percent shooting and allowing 91 points on 38.9 percent shooting. Jaylen Brown is averaging 26 points and 4 rebounds, while Jayson Tatum is averaging 25 points and 11 rebounds. Neemias Queta is the third double-digit scorer, and Sam Hauser is grabbing 7 rebounds. The Boston Celtics are shooting 36.4 percent from beyond the arc and 77.3 percent from the free throw line. The Boston Celtics are allowing 17.4 percent shooting from deep and are grabbing 43 rebounds per game.
Why the Boston Celtics will win
- The Celtics have won each of their last eight games against the 76ers following a home win.
- The 76ers have lost nine of their last 10 road games against teams that held a winning record.
- The Celtics have covered the spread in each of their last seven home games.
- The 76ers have failed to cover the spread in each of their last five games against Atlantic Division opponents.
Why the Philadelphia 76ers will win
- The 76ers have won eight of their last nine games against Atlantic Division opponents following a loss.
- The Celtics have lost two of their last three playoff games as favorites following a win.
- The 76ers have covered the spread in each of their last five road games against Atlantic Division opponents following a loss.
- The Celtics have failed to cover the spread in three of their last four playoff games following a win.
Total Points Facts
- Each of the 76ers’ last eight games as underdogs has gone UNDER the total points line.
- Each of the Celtics’ last eight home games against Eastern Conference opponents has gone UNDER the total points line.
Boston Celtics Player Facts
- The Celtics are allowing just 101.9 points per 48 minutes while Neemias Queta is on the floor this season—the lowest mark of any qualified player in the league.
- Jaylen Brown ranks 1st in the Eastern Conference amongst qualified players for points per game (28.7) this season.
Philadelphia 76ers Player Facts
- Tyrese Maxey ranks 1st in the league for fast break points (382) this season.
- Andre Drummond has recorded 11+ rebounds in three consecutive appearances—the equal-longest active streak of any player in the league.
Matchup/League Facts
- The Celtics rank 1st in the league for opponent points per game this season (107.2).
- The Celtics rank 1st in the league for opponent steals per game this season (6.2).
- The 76ers rank 29th in the league for assists per game this season (24.6).
- The 76ers rank 29th in the league for Q3 points per game this season (27.3).
Celtics vs 76ers Injury Report
Ron Harper Jr. is questionable for the Celtics with an ankle injury.
The 76ers will be without Joel Embiid.
Celtics vs 76ers Prediction
The 76ers looked overmatched in game 1 and while you should expect a more competitive game this time around, it’s not enough for me to jump on that side. As I said in the first write-up, when the Celtics are supposed to win big, they do.
Since January 1, the Celtics are 12-3 ATS as a double-digit favorite. The 76ers are 1-6-1 ATS in their last 8 games as a double-digit underdog. The 76ers just don’t have enough offense to compete in this series and of course the Embiid injury doesn’t help. Big number, but it’s not scaring me off. The Celtics should make light work of the 76ers.

