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Celtics vs Pacers Prediction 1/21/26 NBA Picks Today

Indiana Pacers (10-34) vs. Boston Celtics (26-16)
January 21, 2026 7:30 pm EDT
The Line: Boston Celtics -10.5; Over/Under: 226.5
(Get latest betting odds)

The Indiana Pacers and Boston Celtics meet Wednesday in NBA action at the TD Garden. Here’s a Celtics vs Pacers Prediction. This article will include a Celtics vs Pacers Pick.

Indiana Pacers Betting Preview

The Indiana Pacers lost to the Pistons and 76ers, and they play the Thunder next. The Pacers have lost 3 of their last 4 games.

The Indiana Pacers are averaging 110.6 points on 44.2 percent shooting and allowing 118.3 points on 48.3 percent shooting. Pascal Siakam is averaging 23.6 points and 6.9 rebounds, while Bennedict Mathurin is averaging 17.8 points and 5.5 rebounds. Andrew Nembhard is the third double-digit scorer, and Obi Toppin is grabbing 6.7 rebounds. The Indiana Pacers are shooting 34.3 percent from beyond the arc and 77.6 percent from the free-throw line. The Indiana Pacers are allowing 33.6 percent shooting from deep and are grabbing 42.8 rebounds per game.

Boston Celtics Betting Preview

The Boston Celtics beat the Hawks, lost to the Pistons, and they play the Nets next. The Celtics have won 18 of their last 26 games.

The Boston Celtics are averaging 117.2 points on 47.3 percent shooting and allowing 110.5 points on 45 percent shooting. Jaylen Brown is averaging 29.5 points and 6.4 rebounds, while Derrick White is averaging 18.6 points and 4.4 rebounds. Payton Pritchard is the third double-digit scorer and Anfernee Simons is grabbing 2.3 rebounds. The Boston Celtics are shooting 37.1 percent from beyond the arc and 79 percent from the free throw line. The Boston Celtics are allowing 36.8 percent shooting from deep and are grabbing 44.4 rebounds per game.

Why the Boston Celtics will win

  • The Pacers have lost each of their last 15 road games against teams that held a winning record.
  • The Celtics have won 14 of their last 16 home games against the Pacers.
  • The Pacers have failed to cover the spread in each of their last four road games against Eastern Conference opponents that held a winning record.
  • The Celtics have covered the spread in six of their last seven games following a road loss.

Why the Indiana Pacers will win

  • The Celtics have lost each of their last three games as favorites against Central Division opponents following a loss.
  • The Pacers have won 15 of their last 30 games as road underdogs against Eastern Conference opponents following a loss.
  • The Pacers have covered the spread in each of their last four games against the Celtics following a road loss.
  • The Celtics have failed to cover the spread in four of their last five home games.

Total Points Facts

  • Each of the Pacers’ last seven games against Eastern Conference opponents have gone UNDER the total points line.
  • Nine of the Celtics’ last 10 games against Central Division opponents have gone UNDER the total points line.

Boston Celtics Player Facts

  • Payton Pritchard has recorded 10 games with 4+ assists and zero turnovers this season – most of any player in the league.
  • Neemias Queta ranks 1st in the Eastern Conference amongst qualified players for FG% (65.9%) this season.

Indiana Pacers Player Facts

  • Jay Huff ranks 1st amongst qualified players for blocks per 36 minutes (3.8) this season.
  • T.J. McConnell ranks 2nd amongst qualified players for assists per 36 minutes (10.4) this season.

Matchup/League Facts

  • The Celtics rank 1st in the league for opponent steals per game this season (5.8).
  • The Celtics rank 1st in the league for turnovers per game this season (12.1).
  • The Pacers rank 30th in the league for field goal percentage this season (44.3%).
  • The Pacers rank 1st in the league for opponent three-point field goals made per game this season (11.4).

Celtics vs Pacers Injury Report

The Celtics will be without Jayson Tatum and Josh Minott.

The Pacers will be without Tyrese Haliburton, Obi Toppin, and Bennedict Mathurin.

Celtics vs Pacers Prediction

The Celtics should be favored, as they’re obviously the better team at home, and the Pacers are back to their losing ways. However, the Pacers have played improved ball over the last couple of weeks, as they’re as healthy as they’ve been all season. We’ve seen the Celtics outright lose twice this season as a double-digit favorite. Also, the underdog has covered 7 of the last 10 games between the Celtics and Pacers. This line feels too thick. I’ll take a stab with the Pacers and the boatload of points.

Randy Chambers's Free Pick: Indiana Pacers +10.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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