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Pacers vs 76ers Prediction 10/28/26 NBA Picks Today

Philadelphia 76ers (3-1) vs. Indiana Pacers (2-2)
October 28, 2026 7:00 pm EDT
The Line: Indiana Pacers +4.5; Over/Under: 237.5
(Get latest betting odds)

The 76ers and Indiana Pacers meet Wednesday in NBA action at the Gainbridge Fieldhouse. Here’s a Pacers vs. 76ers Prediction. This article will include a Pacers vs. 76ers pick.

76ers Betting Preview

The Philadelphia 76ers beat the Bucks, lost to the Pistons, and they play the Knicks next. The 76ers have won 12 of their last 18 regular season games.

The Philadelphia 76ers are averaging 110 points on 42 percent shooting and allowing 107 points on 43 percent shooting. Tyrese Maxey is averaging 28.8 points and 4.8 assists, while Joel Embiid is averaging 21.7 points and 9.7 rebounds. Jaylen Brown is the third double-digit scorer, and LeBron James is grabbing 7 rebounds. The Philadelphia 76ers are shooting 31.7 percent from beyond the arc and 75.4 percent from the free-throw line. The Philadelphia 76ers are allowing 33.1 percent shooting from deep and grabbing 41.5 rebounds per game.

Indiana Pacers Betting Preview

The Indiana Pacers beat the Nets, lost to the Bucks, and they play the Heat next. The Pacers have lost 7 of their last 10 games.

The Indiana Pacers are averaging 116.5 points on 48.5 percent shooting and allowing 115 points on 44.1 percent shooting. Pascal Siakam is averaging 23.5 points and 7.8 rebounds, while Tyrese Haliburton is averaging 21.8 points and 4.5 rebounds. Andrew Nembhard is the third double-digit scorer, and Obi Toppin is grabbing 5 rebounds. The Indiana Pacers are shooting 32.7 percent from beyond the arc and 70.1 percent from the free-throw line. The Indiana Pacers are allowing 34 percent shooting from deep and are grabbing 43.3 rebounds per game.

Why the Indiana Pacers will win

  • The 76ers have lost each of their last eight games at Gainbridge Fieldhouse following a home loss.
  • The Pacers have won 13 of their last 15 home games after losing as favorites.
  • The Pacers have covered the spread in each of their last six games against Eastern Conference opponents following a loss.
  • The 76ers have failed to cover the spread in each of their last four games at Gainbridge Fieldhouse when playing with a rest advantage.

Why the Philadelphia 76ers will win

  • The Pacers have lost 15 of their last 16 home games.
  • The 76ers have won each of their last eight games as favorites against Central Division opponents.
  • The 76ers have covered the spread in each of their last four road games following a loss.
  • The Pacers have failed to cover the spread in five of their last six games as underdogs after losing as favorites.

Total Points Facts

  • Each of the 76ers’ last four games against the Pacers following a home loss have gone UNDER the total points line.
  • Each of the Pacers’ last six Wednesday games have gone OVER the total points line.

Indiana Pacers Player Facts

  • Pascal Siakam ranks T6th in the Eastern Conference amongst qualified players for points per game (23.5) this season.
  • Jay Huff ranks T16th in the Eastern Conference amongst qualified players for blocks per game (1.0) this season.

Philadelphia 76ers Player Facts

  • Jaylen Brown has recorded four games with 4+ assists this season – tied for the most of any player in the league.
  • Tyrese Maxey has recorded four games with 4+ assists this season – tied for the most of any player in the league.

Matchup/League Facts

  • The Pacers have used four different starting fives this season – equal-most in the league.
  • The Pacers rank T1st for points in the paint (228) this season.
  • The 76ers rank T1st in the league for opponent assists per game this season (21.0).
  • The 76ers rank 30th in the league for opponent rebounds per game this season (53.8).

Pacers vs 76ers Injury Report

The 76ers will be without Dominick Barlow due to a back issue. Tacko Fall is out with a quad strain. Ariel Hukporti is out with an Achilles injury. Jabari Walker is out with knee soreness.

The Pacers will be without Johnny Furphy due to an ACL injury. Tyrese Haliburton is questionable with a hamstring issue. T.J. McConnell is out with a hamstring issue. Ben Sheppard is out with a meniscus tear. Obi Toppin is probable despite a hand sprain. Aaron Nesmith is probable despite a hamstring issue. Ivica Zubac is out with an ankle injury.

Pacers vs 76ers Prediction

The Pacers are still trying to work their way back to what they were a couple of years ago. It’s a work in progress as they already have a couple of questionable losses. We’re also seeing a ridiculous, lengthy injury report, and of course that was the issue last season. Not sure what’s in the water in Indiana, but guys are getting hurt at an alarming rate. The 76ers look healthy, and just from that alone, the talent should win here, especially if the Pacers are going to be down half their rotation. Can argue this line should be steeper. Give me the 76ers and the chalk.

Randy Chambers's Free Pick: Philadelphia 76ers -4.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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