Arizona Cardinals vs Jacksonville Jaguars Prediction 11/23/25 NFL Picks Today

The Jacksonville Jaguars and the Arizona Cardinals meet Sunday in NFL action from State Farm Stadium. Here’s a Cardinals vs Jaguars prediction. We will look at this from a betting perspective and determine the best Cardinals vs Jaguars pick.

Jacksonville Jaguars Betting Preview

The Jaguars kicked off the season on a nice 4-1 run, falling to only the Cincinnati Bengals while otherwise beating the Carolina Panthers, Houston Texans, San Francisco 49ers and Kansas City Chiefs in that time. Jacksonville would lose three of the next four though, beating only the Raiders in overtime among losses to the Seattle Seahawks, Los Angeles Rams and Houston Texans. The Jaguars fell 36-29 versus Houston on November 9, notching just 213 total yards, 119 passing yards, 3.9 yards per play, 19 first downs and 4-of-11 on third-down tries. Jacksonville notched two turnovers and the team committed nine penalties as well.

In their last outing on Sunday versus the Chargers, Jacksonville continued to chug along and keep themselves above the .500 mark. The Jags scored points in every quarter—including 14 in the fourth—on the way to a blowout home win 35-6. QB Trevor Lawrence was 14-of-22 for 153 yards, one TD and one interception while also scoring a rush touchdown. Lead rusher Bhayshul Tuten had 74 yards and a score off 15 carries, and Travis Etienne notched two touchdowns among his 19 carries for 73 yards. Jakobi Meyers caught five balls for 64 yards as the team’s leading receiver in the victory effort.

Arizona Cardinals Betting Preview

Over on the Arizona side, they won their first two games versus New Orleans and Carolina, then hit the skids. The Cardinals lost the next five versus the San Francisco 49ers, Seattle Seahawks, Tennessee Titans, Indianapolis Colts and GreenBay Packers. After a win versus the Dallas Cowboys, Arizona fell back into the loss column versus the Seattle Seahawks on November 9 by a score of 44-22. In that one the Cards gave up 21 points in the first quarter along with 372 yards, 22 first downs, 6.3 yards per play and 6-of-10 on third-down tries. The defense did come up with three takeaways, but it hardly mattered in the end result.

Matched up against the 49ers last weekend, the Cardinals were looking at a 25-10 deficit by the break. Arizona ended up surrendering points in every quarter—including double-digits in each of the first three—during a 41-22 blowout loss at home. QB Jacoby Brissett had 452 yards, two scores and two picks on 47-of-57 passing, and Zonovan Knight carried five times for 24 yards and a touchdown. Michael Wilson had a stellar statistical day on 15 catches for 185 yards, as did Trey McBride on 10 catches for 115 yards and a score.

Jacksonville Jaguars @ Arizona Cardinals Betting Trends: Week 12

Why the Arizona Cardinals will win

• The Jaguars have lost each of their last nine games against NFC opponents on a losing streak.
• The Cardinals have won three of their last four games as underdogs against AFC opponents.
• The Cardinals have covered the spread in each of their last seven games as underdogs against AFC opponents.
• The Jaguars have failed to cover the spread in eight of their last nine games against NFC West opponents.
• The Cardinals have won the first quarter in each of their last four Week 12 games as underdogs.
• The Jaguars have lost the first half in seven of their last eight November games against NFC opponents.
• The Cardinals have scored the first touchdown in nine of their last 10 Sunday home games.

Why the Jacksonville Jaguars will win

• The Cardinals have lost each of their last nine games against teams that held a winning record.
• The road team has won four of the last five games between the Jaguars and Cardinals.
• The road team has covered the spread in eight of the Cardinals’ last 10 games.
• The Cardinals have failed to cover the spread in four of their last five home games.
• The Jaguars have scored the first touchdown in four of their last five games following a win.
• The road team has won the first quarter in each of the Jaguars’ last four Week 12 games.
• The Cardinals have lost the first half in seven of their last eight games against teams that held a winning record.

Total Points Facts

• Each of the Cardinals’ last seven Sunday home games have gone OVER the total points line.
• Ten of the Jaguars’ last 11 games following a win have gone OVER the total points line.
• Seventeen of the last 21 Sunday games at State Farm Stadium have gone OVER the total points line.

Arizona Cardinals Player Prop Facts

• Jacoby Brissett has recorded 258+ passing yards in each of the Cardinals’ last five games.
• Trey McBride has scored at least one touchdown in each of the Cardinals’ last six day games against teams that held a winning record.
• Michael Carter has recorded 34+ rushing yards in five of his six previous appearances against AFC South opponents.
• Michael Carter has recorded 10+ receiving yards in eight of his last nine home appearances against AFC opponents.
• Michael Carter has recorded 24+ rushing and receiving yards in each of his seven previous November home appearances.
• Jacoby Brissett has recorded 22+ completions in each of the Cardinals’ last four Sunday games.
• Heading into Week 12, Jacoby Brissett has recorded the most completions in a single game this season (47 vs 49ers, Week 11).

Jacksonville Jaguars Player Prop Facts

• Jakobi Meyers has scored a touchdown in seven of his last eight appearances with his team as a favorite against NFC opponents.
• Trevor Lawrence has recorded 18+ rushing yards in three of the Jaguars’ last four games.
• Dyami Brown has recorded 13+ receiving yards in each of his last 10 appearances against NFC opponents.
• Jakobi Meyers has recorded 52+ rushing and receiving yards in each of his six previous Week 12 appearances.
• Trevor Lawrence has recorded 211+ passing yards in each of the Jaguars’ last seven games as slight favorites (<-3.5 points).
• Trevor Lawrence has recorded 20+ completions in each of the Jaguars’ last seven games as favorites following a win.
• Heading into Week 12, Devin Lloyd has recorded the equal-most interceptions in a single game this season (2 vs 49ers, Week 4).

Matchup/League Facts

• Cardinals – four different players have recorded 50+ rushing yards in a game this season – equal-most in the NFL, heading into Week 12.
• Heading into Week 12, the Cardinals have suffered the equal-most losses when leading after Q3 this season (4).
• Heading into Week 12, the Jaguars rank 1st in the NFL in average punt return (16.6 yards) this season.
• Heading into Week 12, the Jaguars rank 1st in the NFL in time of possession per game (32:45) this season.

Cardinals vs Jaguars Prediction

I’ll lean toward the Jags here. Jacksonville had a great game versus the Chargers over the weekend and excelled on both sides. The Jaguars posted 345 yards on offense, 192 rush yards, 5.0 yards per play, 30 first downs and just one team penalty. The defense held the opposition to just 135 yards, 3.0 yards per play, eight first downs and 3-of-12 on third-down tries. The Jaguars have scored 29 or more points in three straight games, winning two of those.

As for Arizona, they gained 488 total yards, 452 pass yards and 24 first downs in their loss to the Niners. Trouble is, the Cards also put up just 6-of-14 on third downs, three turnovers and 17 penalties for 130 yards. The defense only gave up 281 yards and 3-of-9 on third downs but San Francisco still scored 41 points due to all the miscues. Arizona needs to shore up a lot of areas before this weekend’s game.