Bills vs Browns Prediction 12/21/25 NFL Picks Today

In this article, we will formulate a Bills vs Browns Prediction for this NFL Week 13 game on Sunday, December 21^st. Let’s take a look at the prediction for this NFL matchup.

Cleveland Browns Preview

The Cleveland Browns have a 3-11 record this season and are sitting fourth in the AFC North. They are 5-9 ATS, 7-7 in Over/Under and have a 2-5 home record and a 1-6 away record. The Browns are coming off a 3-31 away loss against the Chicago Bears and will face the Steelers and Bengals next.

Offensively, the Browns average 16.1 points per game, ranking 29th in the NFL, while defensively, they allow 23.7 points per game, which is 19th. Cleveland averages 264.3 total yards per game (171.9 passing and 92.4 rushing), while allowing 279.1 total yards per game (110.1 rushing and 169 passing).

Shedeur Sanders leads the Browns with 946 passing yards with 52.2% completed passes and 5 touchdowns. Quinshon Judkins leads the team in rushing yards with 805, while Harold Fannin has a team-high 66 receptions for 667 receiving yards, and 4 touchdowns. Defensively, Carson Schwesinger has a team-high 133 total tackles (59 of them solo), while Myles Garrett leads the team in sacks, with 21.5.

Buffalo Bills Preview

The Buffalo Bills have a 10-4 record this season and are sitting second in the AFC East. They are 7-7 ATS, 7-7 in Over/Under and have a 6-1 home record and a 4-3 away record. The Bills are coming off a 35-31 away win against the New England Patriots and will face the Eagles and Jets next.

Offensively, the Bills average 29.4 points per game, ranking 3rd in the NFL, while defensively, they allow 23.1 points per game, which is 16th. Buffalo averages 381.2 total yards per game (222.7 passing and 158.5 rushing), while allowing 312.6 total yards per game (143.1 rushing and 169.5 passing).

Josh Allen leads the Bills with 3276 passing yards with 70% completed passes and 25 touchdowns. James Cook leads the team in rushing yards with 1415, while Khalil Shakir has a team-high 62 receptions for 650 receiving yards, and four touchdowns. Defensively, Cole Bishop has a team-high 76 total tackles (46 of them solo), while Joey Bosa leads the team in sacks, with 5, while Cole Bishop, Christian Benford, Maxwell Hairston and A.J. Epenesa each have two interceptions.

Buffalo Bills @ Cleveland Browns Betting Trends: Week 16

Why the Cleveland Browns will win

• The Bills have lost each of their last two games as heavy favorites (>-7.0 points).
• The Browns have won 10 of their last 14 home games against teams that held a winning record.
• The Bills have failed to cover the spread in each of their last four road games without Dawson Knox.
• The Browns have covered the spread in each of their last four games at Huntington Bank Field following a road loss.
• The underdogs have won the first quarter in each of the Bills’ last four Week 16 games.
• The Browns have scored the first touchdown in six of their last seven games against AFC East opponents.
• The Bills have lost the first half in each of their last six games as favorites against AFC opponents.

Why the Buffalo Bills will win

• The Bills have won each of their last 11 December games against AFC opponents.
• The Browns have lost each of their last eight games against AFC opponents on a winning streak.
• The Browns have failed to cover the spread in each of their last 10 games as underdogs without Cedric Tillman.
• The Bills have covered the spread in six of their last seven December road games against AFC opponents.
• The Browns have lost the first quarter in each of their last five games in December.
• The Browns have lost the first half in each of their last 11 Sunday games against teams that held a winning record.

Total Points Facts

• Each of the Browns’ last eight Week 16 games as underdogs have gone UNDER the total points line.
• Each of the Bills’ last six road games against AFC North opponents have gone UNDER the total points line.
• Three of the last four Sunday games at Huntington Bank Field have gone OVER the total points line.

Cleveland Browns Player Prop Facts

• Deshaun Watson has scored a touchdown in each of his last three appearances against AFC East opponents.
• Deshaun Watson has recorded 25+ rushing yards in each of his last four December appearances with his team as an underdog.
• Deshaun Watson has recorded 275+ passing yards in five of his last six appearances with his team as a home underdog.
• Cedric Tillman has recorded 23+ receiving yards in each of his last seven home appearances against AFC opponents.
• Deshaun Watson has recorded 25+ completions in five of his last six appearances with his team as a home underdog.
• Heading into Week 16, Myles Garrett ranks 1st in the NFL in sacks (21.5) this season.

Buffalo Bills Player Prop Facts

• Josh Allen has scored two or more touchdowns in three of the Bills’ last four December road games.
• Josh Allen has recorded 19+ completions in each of the Bills’ last six games following a win.
• Josh Allen has recorded 223+ passing yards in six of the Bills’ last seven December road games against AFC opponents.
• James Cook has scored at least one touchdown in each of the Bills’ last six games against teams on a losing streak.
• Dawson Knox has recorded 17+ receiving yards in each of the Bills’ last seven games.
• James Cook has recorded 111+ rushing and receiving yards in seven of the Bills’ last eight games.
• James Cook has recorded 87+ rushing yards in six of the Bills’ last seven road games.
• Heading into Week 16, Josh Allen is the only player in the NFL to record 2,000 passing yards and 500 rushing yards this season.

Matchup/League Facts

• Heading into Week 16, the Browns rank 1st in the NFL in passing yards allowed per game (169.0) this season.
• Heading into Week 16, the Browns rank 1st in the NFL in total punt yards (3609) this season.
• Bills – eight different players have recorded 60+ receiving yards in a game this season – most in the NFL, heading into Week 16.
• Bills – five different players have recorded 90+ receiving yards in a game this season – equal-most in the NFL, heading into Week 16.

Bills vs Browns Prediction

In this Bills vs Browns Prediction, the Bills are coming as -10-point road favorites. The Bills have been the better team this season, as they have 10 total wins as opposed to the Browns’ 3. They also have four road wins while the Browns have just two at home and are coming into this matchup in good form, with three consecutive wins, while on the other hand, the Browns are 1-6 in their last 7 games and 2-5 against the spread. The Bills have the third-best offense in the league and are going up against the Browns’ fourth-worst, so I expect them to get the job done easily on the road today. Take the Bills and lay the -10 on the road.