Bills vs Chargers Prediction 9/27/26 NFL Picks Today

The Los Angeles Chargers and Buffalo Bills meet Sunday in NFL action at Highmark Stadium. Here’s a Bills vs. Chargers Prediction. This article will include a Bills vs. Chargers Pick.

Los Angeles Chargers Betting Preview

The Los Angeles Chargers lost to the Cardinals and Raiders, and they play the Seahawks next. The Los Angeles Chargers haven’t started 0-3 since the 2017 season. Justin Herbert is completing 59.3 percent of his passes for 401 yards, 2 touchdowns, and 3 interceptions. Ladd McConkey and Tre’ Harris have combined for 190 receiving yards and 1 touchdown, while David Njoku has 6 receptions.

The Los Angeles Chargers’ ground game is averaging 104 yards per contest, and Omarion Hampton leads the way with 137 yards and 2 touchdowns. Defensively, Los Angeles is allowing 26 points and 349 yards per game. Derwin James Jr. leads the Los Angeles Chargers with 17 tackles, Khalil Mack has 1 sack, and Cam Hart has 1 interception.

Buffalo Bills Betting Preview

The Buffalo Bills beat the Texans and Lions, and they play the Patriots next. The Bills look to start 3-0 for a third straight season. Josh Allen is completing 66.7 percent of his passes for 582 yards, 5 touchdowns, and 0 interceptions. Dalton Kincaid and DJ Moore have combined for 325 receiving yards and 2 touchdowns, while Khalil Shakir has 7 receptions.

The Buffalo Bills ground game is averaging 144.5 yards per contest, and James Cook III leads the way with 192 yards and 1 touchdown. Defensively, Buffalo is allowing 31 points and 368 yards per game. Terrel Bernard leads the Buffalo Bills with 17 tackles, Greg Rousseau has 4 sacks, and Deone Walker has 3 pass deflections.

Why the Buffalo Bills will win

• The Bills have won each of their last 17 home games against opponents on a losing streak.
• The Chargers have lost each of their last nine games as underdogs against opponents on a winning streak.
• The Chargers have failed to cover the spread in each of their last six games as road underdogs against AFC East opponents.
• The Bills have covered the spread in each of their last four games when playing with a rest advantage.
• The Chargers have lost the first quarter in five of their last six road games against AFC opponents.
• The Chargers have lost the first half in each of their last six games as road underdogs against AFC East opponents.
• The Bills have scored the first touchdown in 10 of their last 11 Week 3 games.

Why the Los Angeles Chargers will win

• The Chargers have won each of their six previous September games against the Bills.
• The Bills have lost three of their last four games as favorites following a home win.
• The Bills have failed to cover the spread in five of their last six games without Dawson Knox.
• The Chargers have covered the spread in five of their last six road openers.
• The Chargers have won the first quarter in seven of their last eight September games as underdogs.
• The Chargers have won the first half in each of their last eight September games as underdogs.
• The Chargers have scored the first touchdown in six of their last seven Week 3 games.

Total Points Facts

• Each of the Bills’ last nine home games in September have gone OVER the total points line.
• Eleven of the Chargers’ last 12 road games in September have gone UNDER the total points line.

Buffalo Bills Player Prop Facts

• Josh Allen has scored the last touchdown in each of the Bills’ last three regular season games as favorites against AFC West opponents.
• Josh Allen has scored two touchdowns in three of the Bills’ last four games.
• James Cook has recorded 85+ rushing yards in each of the Bills’ last four games against AFC West opponents.
• Dawson Knox has recorded 15+ receiving yards in each of the Bills’ last 10 Sunday games played on the East Coast.
• Josh Allen has recorded 22+ completions in each of the Bills’ last seven September home games against AFC opponents.
• Josh Allen has recorded 248+ passing yards in each of the Bills’ last five games with a total points line of at least 50.0.
• James Cook has recorded 102+ rushing and receiving yards in each of the Bills’ last five home games with a total points line of at least 50.0.
• James Cook has scored at least one touchdown in seven of the Bills’ last eight games against teams on a losing streak.
• Heading into Week 3, Gregory Rousseau ranks 1st in the NFL in sacks (4.0) this season.

Los Angeles Chargers Player Prop Facts

• Justin Herbert has recorded 229+ passing yards in 10 of the Chargers’ last 11 games with a total points line of at least 50.0.
• Quentin Johnston has recorded 48+ receiving yards in seven of his last eight regular-season road appearances.
• Keaton Mitchell has recorded 24+ rushing yards in five of his last six appearances following a loss.
• Omarion Hampton has scored a touchdown in each of his last four regular season appearances.
• Justin Herbert has recorded 20+ completions in each of the Chargers’ last 12 games with a total points line of at least 50.0.
• Quentin Johnston has recorded 48+ rushing and receiving yards in seven of his last eight regular season road appearances.
• Heading into Week 3, Omarion Hampton ranks 1st in the NFL in broken tackles (7) this season.

Matchup/League Facts

• Bills – four different players have recorded 50+ receiving yards in a game this season – equal-most in the NFL, heading into Week 3.
• Bills – two different players have recorded 90+ receiving yards in a game this season – tied for the most in the NFL, heading into Week 3.
• Heading into Week 3, the Chargers have lost the second quarter in each of their last two games – equal-longest active streak in the league.
• Heading into Week 3, the Chargers have lost the fourth quarter in each of their last two games – equal-longest active streak in the league.

Bills vs Chargers Prediction

The Chargers have been the most disappointing team in the league through two games, as there’s great talent on both sides of the ball, and they lost twice at home as big favorites. It’s to the point where the Chargers have to consider making changes. I highly doubt a trip across the country to play this hot Bills team flips the switch. The defense can’t get off the field, and Herbert looks broken under new OC Mike McDaniel. I expect a double-digit win from the Bills, as these Chargers are in awful form out of the gate, and it’s a shame because this is a Super Bowl contender if things were clicking.