Bills vs Chiefs Prediction 11/2/25 NFL Picks Today

The Kansas City Chiefs and Buffalo Bills meet Sunday in NFL action at Highmark Stadium. Here’s a Bills vs Chiefs Prediction. This article will include a Bills vs Chiefs Pick.

Kansas City Chiefs Betting Preview

The Kansas City Chiefs beat the Raiders and Commanders, and they play the Broncos next. The Kansas City Chiefs have won 3 straight games. Patrick Mahomes is completing 67 percent of his passes for 2,009 yards, 17 touchdowns, and 4 interceptions. Hollywood Brown and Travis Kelce have combined for 790 receiving yards and 7 touchdowns, while Tyquan Thornton has 14 receptions.

The Kansas City Chiefs ground game is averaging 126.5 yards per contest, and Isiah Pacheco leads the way with 329 yards and 1 touchdown. Defensively, Kansas City is allowing 16.4 points and 277.8 yards per game. Chamarri Conner leads the Kansas City Chiefs with 63 tackles, George Karlaftis has 4.5 sacks and Chris Roland-Wallace has 1 interception.

Buffalo Bills Betting Preview

The Buffalo Bills lost to the Falcons, beat the Panthers, and they play the Dolphins next. The Bills have won 5 of their last 7 games. Josh Allen is completing 68 percent of his passes for 1,560 yards, 12 touchdowns, and 4 interceptions. Khalil Shakir and Dalton Kincaid have combined for 666 receiving yards and 6 touchdowns, while Keon Coleman has 27 receptions.

The Buffalo Bills ground game is averaging 164.4 yards per contest, and James Cook leads the way with 753 yards and 7 touchdowns. Defensively, Buffalo is allowing 20.9 points and 312.1 yards per game. Cole Bishop leads the Buffalo Bills with 34 tackles, Ed Oliver has 3 sacks and AJ Epenesa has 1 interception.

Why the Buffalo Bills will win

• The Bills have won each of their last 17 games following a road win.
• The Chiefs have lost 16 of their last 20 Week 9 road games against AFC opponents.
• The underdogs have covered the spread in each of the Chiefs’ last six Week 9 games.
• The Chiefs have failed to cover the spread in seven of their last eight November games as favorites.
• The Bills have won the first half in each of their last nine November games against the Chiefs.
• The Bills have scored the first touchdown in each of their last five Sunday games.
• The Bills have won the first quarter in each of their last five November games against the Chiefs.

Why the Kansas City Chiefs will win

• The Chiefs have won each of their last 10 November games as favorites against AFC opponents.
• The Bills have lost eight of their last 10 Week 9 games against AFC opponents.
• The Bills have failed to cover the spread in each of their last five Week 9 games against AFC opponents.
• The Chiefs have covered the spread in each of their last four Sunday games.
• The Chiefs have won the first half in nine of their last 10 games as favorites against AFC opponents.
• The Chiefs have scored the first touchdown in nine of their last 10 games as favorites against AFC opponents.
• The Chiefs have won the first quarter in each of their last five Week 9 games against AFC opponents.

Total Points Facts

• Seven of the Chiefs’ last eight games against the Bills following a win have gone OVER the total points line.
• Seven of the Bills’ last eight home games following a road win have gone OVER the total points line.
• Three of the last four Sunday games at Highmark Stadium have gone OVER the total points line.

Buffalo Bills Player Prop Facts

• Josh Allen has scored two or more touchdowns in four of the Bills’ last five games with a total points line of at least 50.0.
• Josh Allen has scored at least one touchdown in each of the Bills’ last 14 games against teams on a winning streak.
• Josh Allen has recorded 22+ completions in each of the Bills’ last six games against the Chiefs.
• Josh Allen has recorded 39+ rushing yards in each of the Bills’ last four games against AFC West opponents.
• Josh Allen has recorded 258+ passing yards in nine of the Bills’ last 10 games as underdogs with a total points line of at least 50.0.
• James Cook has recorded 15+ receiving yards in nine of the Bills’ last 10 games as underdogs.
• James Cook has recorded 95+ rushing and receiving yards in six of the Bills’ last seven regular season games as underdogs.
• Josh Allen has scored the last touchdown in three of the Bills’ last four regular season games against AFC West opponents.
• Heading into Week 9, James Cook ranks 1st amongst qualified players for Yards Per Carry (6.0) this season.

Kansas City Chiefs Player Prop Facts

• Rashee Rice has scored at least one touchdown in each of his last four appearances following a home win.
• Patrick Mahomes has recorded 298+ passing yards in eight of the Chiefs’ last nine November games as favorites against AFC opponents.
• Travis Kelce has recorded 64+ receiving yards in each of the Chiefs’ last 12 November games as favorites against AFC opponents.
• Patrick Mahomes has recorded 28+ rushing yards in each of the Chiefs’ last four games.
• Patrick Mahomes has recorded 24+ completions in each of the Chiefs’ last seven November games as favorites.
• Xavier Worthy has recorded 51+ rushing and receiving yards in seven of the Chiefs’ last eight games as favorites following a win.
• Heading into Week 9, Patrick Mahomes ranks T1st in the NFL in passing touchdowns (17) this season.

Matchup/League Facts

• Heading into Week 9, the Bills rank 1st in the NFL in rushing yards per game (164.4) this season.
• Heading into Week 9, the Bills rank 1st in the NFL in forced fumbles (10) this season.
• Chiefs – five different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 9.
• Chiefs – four different players have recorded 90+ receiving yards in a game this season – equal-most in the NFL, heading into Week 9.

Bills vs Chiefs Prediction

The Chiefs should be favored, as they look like a team that’s getting its act together and becoming the Chiefs we all know and love. The Bills have also had issues getting over the hump when playing the Chiefs. However, the Bills have the offense to go toe-to-toe with the Chiefs, and this will be just the fourth time since 2021 where they’re a home underdog. The Bills have outright won their last 4 home games as an underdog. The Chiefs have failed to cover 5 of their last 8 road games as a favorite. Four of the last five meetings between the Bills and Chiefs have been decided by 4 or fewer points. The value is with the Bills and the points. I’ll take them.