Broncos vs Jaguars Prediction 9/20/26 NFL Picks Today

In this article we will formulate a Broncos vs Jaguars prediction for this NFL game on Sunday, September 20th at Mile High Stadium in Denver, Colorado. Let’s take a look at the prediction for this week 2 matchup.

Denver Broncos Betting Preview

The Denver Broncos are 0-1 this season after they lost to the Chiefs by a score of 31-10 last week. Denver trailed 14-7 at halftime and they only scored three points in the second half for the lopsided loss. The Broncos were out gained by a total of 392-176, went 2-12 on third downs, and lost the turnover battle by a total of 2-1 in the game. Bo Nix threw for 131 yards, one touchdown, and one interception, while Evan Engram caught four passes for 43 yards and one score. JK Dobbins rushed eight times for 36 yards in the loss. 

The Broncos were 14-3 last year and they finished first in the AFC West standings, three games ahead of the Chargers in second. Denver started the season with a 1-2 record, but they won 11 games in a row, before going 2-1 in their last three. The Broncos only lost to the Colts, Chargers, and Jaguars in the regular season, but they scored 20 points or fewer in five of their last nine games. Denver defeated the Bills in overtime by a score of 33-30 in the playoffs, but lost to the Patriots 10-7. The Broncos scored 23.6 points per game in 2025, while they allowed 18.3 points against per game on defense. 

Jacksonville Jaguars Betting Preview

The Jacksonville Jaguars are 1-0 this year after they defeated the Browns by a score of 34-10 in week one. Jacksonville led 24-0 at halftime and they cruised to the blowout win in the second half. The Jaguars out gained Cleveland by a total of 360-272, went 5-10 on third downs, and won the turnover battle by a total of 2-0 in the game. Trevor Lawrence threw for 245 yards and four touchdowns, while Parker Washington had five receptions for 83 yards and one score. Bhayshul Tuten rushed 15 times for 66 yards in the win. 

The Jaguars were 13-4 last year and they finished first in the AFC South, which was one game better than Houston in second. Jacksonville started the season with a 4-3 record through seven games, but they won nine of their last ten games. The Jaguars finished by winning each of their last eight games in the regular season and they allowed 20 points or fewer in seven of those eight. Jacksonville lost to the Bills by a score of 27-24 in the playoffs. The Jaguars scored 27.9 points per game in 2025, while they allowed 19.8 points against per game on defense. 

Why the Denver Broncos will win

• The Jaguars have lost each of their last nine Week 2 road games.
• The Broncos have won 16 of their last 17 Week 2 home games against AFC opponents.
• The Broncos have covered the spread in each of their last eight games as favorites without Alex Singleton.
• The Jaguars have failed to cover the spread in seven of their last eight games without Brenton Strange.
• The Broncos have won the first half in each of their last eight games as home favorites following a loss.
• The Broncos have scored the first touchdown in each of their last seven games as favorites following a road loss.
• The Jaguars have lost the first quarter in seven of their last eight Week 2 road games.

Why the Jacksonville Jaguars will win

• The Jaguars have won each of their last six games against opponents on a losing streak.
• The Broncos have lost each of their last two games as favorites against AFC South opponents.
• The Jaguars have covered the spread in nine of their last 10 games.
• The Broncos have failed to cover the spread in each of their last four games without Nik Bonitto.
• The Jaguars have won the first half in each of their last five games in September.
• The Jaguars have scored the first touchdown in each of their last seven games following a home win.
• The Jaguars have won the first quarter in each of their last four games as underdogs.

Total Points Facts

• Each of the Broncos’ last seven home openers have gone UNDER the total points line.
• Each of the Jaguars’ last six games as road underdogs following a win have gone OVER the total points line.

Denver Broncos Player Prop Facts

• J.K. Dobbins has scored the last touchdown in three of his last four September appearances with his team as a favorite.
• Courtland Sutton has scored a touchdown in each of the Broncos’ last five games following a road loss.
• Courtland Sutton has recorded 55+ receiving yards in each of the Broncos’ last seven games following a road loss.
• J.K. Dobbins has recorded 63+ rushing yards in each of his last six appearances at Empower Field at Mile High.
• Bo Nix has recorded 247+ passing yards in five of his last six Sunday home appearances.
• J.K. Dobbins has recorded 68+ rushing and receiving yards in each of his last six appearances at Empower Field at Mile High.
• Jarrett Stidham has recorded 17+ completions in each of his five previous appearances as a starter.
• Heading into Week 2, Zach Allen ranks T1st in the NFL in sacks (2.0) this season.

Jacksonville Jaguars Player Prop Facts

• Trevor Lawrence has scored at least one touchdown in each of the Jaguars’ last four games against AFC West opponents.
• Parker Washington has recorded 83+ receiving yards in each of the Jaguars’ last five games.
• Trevor Lawrence has recorded 229+ passing yards in each of the Jaguars’ last eight regular season games.
• Trevor Lawrence has recorded 23+ completions in each of his five previous road appearances against AFC West opponents.
• Trevor Lawrence has recorded 20+ rushing yards in each of the Jaguars’ last six road games.
• Heading into Week 2, Trevor Lawrence ranks 1st in the NFL in passing touchdowns (4) this season.

Matchup/League Facts

• Heading into Week 2, the Broncos rank 32nd in the NFL in yards per game (176.0) this season.
• Heading into Week 2, the Broncos rank 32nd in the NFL in passing yards per game (115.0) this season.
• Jaguars – four different players have recorded 1.0 sacks or more in a game this season – equal-most in the NFL, heading into Week 2.
• Heading into Week 2, the Jaguars rank T1st in the NFL in red zone percentage (100.0%) this season.

Broncos vs Jaguars Prediction 

Denver comes into this matchup looking to bounce back from a rough loss on Monday night, but they will be back at home here. The Broncos only scored 10 points in that loss to the Chiefs and the defense was nowhere near good enough. Jacksonville blew out Cleveland in week one and Lawrence looked very good. The Jaguars looked like the better team, but I expect Denver to play better on both sides of the ball. Take the Broncos to win.