Buffalo Bills vs Philadelphia Eagles Prediction 12/28/25 NFL Picks Today

The Philadelphia Eagles and the Buffalo Bills meet Sunday in NFL action from Highmark Stadium. Here’s a Bills vs Eagles prediction. We will look at this from a betting perspective and determine the best Bills vs Eagles pick.

Philadelphia Eagles Betting Preview

The Eagles went into the bye week this year with a 6-2 overall record. Philly lost to the Broncos and Giants in that time, otherwise beating the Cowboys, Chiefs, Rams, Bucs, Vikings and Giants. After the bye Philadelphia went 4-3 over the next seven games with wins over the Packers, Lions, Raiders and Commanders around losses to the Cowboys, Bears and Chargers. That would make for a 10-5 record in the first 15 games.

In last Saturday’s matchup with the Commanders, the Eagles were down by a field goal at the break. Philly scored 22 more points from there and powered out the 29-18 comeback win, however. QB Jalen Hurts finished with 185 yards and two scores on 22-of-30 passing and Saquon Barkley led the rush with 21 carries for 132 yards and a touchdown. AJ Brown caught nine balls for 95 yards as the team’s leading receiver as well.

Buffalo Bills Betting Preview

Over on the Bills’ side, they beat the Ravens, Jets, Dolphins and Saints before losses to the Patriots and Falcons this year. After the bye, Buffalo hit a 6-2 run in the next eight games with losses to the Dolphins and Texans among wins over the Panthers, Chiefs, Bucs, Steelers, Bengals and Patriots. After their first 14 games of the year the Bills had a 10-4 overall record.

In the Cleveland matchup on Sunday the Bills held a 10-point lead at the break but had to hang on after a slow second half in a 23-20 win. QB Josh Allen was 12-of-19 for 130 yards, and James Cook had 16 carries for 117 yards and a couple of scores. Khalil Shakir had 34 yards on four catches as the top receiver as well.

Philadelphia Eagles @ Buffalo Bills Betting Trends: Week 17

Why the Buffalo Bills will win

• The Bills have won each of their last 20 games following a road win.
• The Eagles have lost three of their last four road games without Jalen Carter.
• The Bills have covered the spread in 10 of their last 11 games against teams that held a winning record.
• The Eagles have failed to cover the spread in four of their last five December games as underdogs.
• The Bills have won the first quarter in each of their last two home games against teams that held a winning record.
• The Bills have scored the first touchdown in each of their last six home games against NFC East opponents.
• The Bills have won the first half in each of their last 10 home games against teams that held a winning record.

Why the Philadelphia Eagles will win

• The Eagles have won each of their last eight Sunday games against teams that held a winning record.
• The Bills have lost each of their last two games as favorites without Gregory Rousseau.
• The Eagles have covered the spread in each of their last six Sunday games against teams that held a winning record.
• The Bills have failed to cover the spread in seven of their last eight games as favorites following a win.
• The Eagles have won the first quarter in nine of their last 10 Sunday games against teams that held a winning record.
• The Eagles have scored the first touchdown in 17 of their last 18 Sunday games.
• The Eagles have won the first half in each of their last seven Sunday games.

Total Points Facts

• Each of the Bills’ last six home games without Dawson Knox have gone UNDER the total points line.
• Each of the Eagles’ last four games against AFC opponents have gone UNDER the total points line.

Buffalo Bills Player Prop Facts

• James Cook has scored two or more touchdowns in four of the Bills’ last five day games against teams on a winning streak.
• Josh Allen has scored at least one touchdown in each of the Bills’ last nine home games against teams on a winning streak.
• Josh Allen has recorded 19+ completions in each of the Bills’ last five games played on the East Coast.
• Josh Allen has recorded 40+ rushing yards in each of the Bills’ last five Sunday games as home favorites.
• James Cook has recorded 111+ rushing and receiving yards in each of the Bills’ last six games.
• Josh Allen has recorded 209+ passing yards in each of the Bills’ last seven home games.
• Keon Coleman has recorded 16+ receiving yards in each of his 12 previous regular season home appearances.
• Heading into Week 17, James Cook ranks 1st in the NFL in rushing yards (1532) this season.

Philadelphia Eagles Player Prop Facts

• A.J. Brown has scored at least one touchdown in seven of the Eagles’ last eight games against teams on a winning streak.
• Jalen Hurts has recorded 197+ passing yards in eight of the Eagles’ last nine Sunday games as road underdogs.
• DeVonta Smith has recorded 60+ receiving yards in each of his last 10 Sunday appearances with the Eagles as underdogs.
• Jalen Hurts has recorded 18+ completions in each of the Eagles’ last four games against AFC East opponents.
• Tank Bigsby has recorded 33+ rushing and receiving yards in each of his last seven appearances with his team as an underdog against AFC opponents.
• Tank Bigsby has recorded 28+ rushing yards in each of his last seven appearances with his team as an underdog against AFC opponents.
• Heading into Week 17, Jalen Hurts has the highest passer rating in a single game (min. 10 ATT) this season (158.3 vs Vikings, Week 7).

Matchup/League Facts

• Bills – eight different players have recorded 60+ receiving yards in a game this season – most in the NFL, heading into Week 17.
• Bills – five different players have recorded 90+ receiving yards in a game this season – equal-most in the NFL, heading into Week 17.
• Eagles – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 17.
• Eagles – two different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 17.

Bills vs Eagles Prediction

I’ll take a stab on the Bills here, but you could call it either way. Buffalo had a pretty rough offensive day versus the Browns last weekend, notching 259 yards with just 95 passing yards, 16 first downs and 2-of-8 on third-down tries. The defense kept the team in there though, giving up 134 pass yards with a couple of interceptions. It was the Bills’ lowest points total (23) during this current four-game win streak; they’d hit a combined 74 in the previous two outings.

As for Philly, they did a pretty good job versus the Commanders last Saturday, hitting 385 total yards, 207 rush yards and 26 first downs. The Eagles gave up 220 yards on the other side with 4.3 yards per play, 15 first downs and just 2-of-10 on third-down tries. Philadelphia has scored a combined 60 points across their last two games, following five straight with fewer than 22 points (a 2-3 run). If the Eagles can keep it up on the scoreboard they’ll be in great shape against Buffalo in this road matchup.