Kansas City Chiefs (0-0) vs. Arizona Cardinals (0-0)
August 9, 2025 8:00 pm EDT
The Line: Arizona Cardinals ; Over/Under:
(Get latest betting odds)
In this article, we will formulate a Cardinals vs Chiefs prediction for this NFL game on Saturday, August 9th at State Farm Stadium in Glendale, AZ. Let’s take a look at the prediction for this Week 1 matchup in the preseason.
Kansas City Chiefs Betting Preview
The Kansas City Chiefs have successfully made it to the Super Bowl for three straight seasons and are once again considered favorites. Since the 2014 season, the Chiefs have not experienced a playoff absence. With Patrick Mahomes remaining healthy and coach Andy Reid on the sidelines, the team is in excellent hands. This partnership is arguably the greatest QB-Coach duo in the history of the NFL. There are some offensive line challenges for the Chiefs, and uncertainty surrounds receiver Rashee Rice, but Mahomes’ presence on the field provides reassurance, irrespective of the rest of the team’s composition.
Defensively, the Chiefs have parted ways with Justin Reid, yet they continue to maintain one of the top defenses under Steve Spagnuolo. The linebacker trio of Nick Bolton, Drue Tranquill, and Leo Chenal is arguably the best in the league. Furthermore, Chris Jones is recognized as one of the top pass rushers, with a career total of 80.5 sacks and 37 pass deflections. Although the Chiefs have their imperfections, particularly regarding the offensive line, the key players have proven they can achieve victory when the pressure is at its peak.
Arizona Cardinals Betting Preview
In 2024, the Arizona Cardinals were able to double their win total, yet they have only made the playoffs once since the 2016 season. Jonathan Gannon is entering his third season as the head coach. Kyler Murray is a dynamic playmaker who has shown glimpses of greatness over six years, but it is imperative that he steps up in terms of consistency that leads to victories. Marvin Harrison Jr. is rising as a superstar receiver, and James Conner has achieved two consecutive 1,000-yard seasons. The Cardinals also possess a competent offensive line, led by Paris Johnson Jr. and Jonah Williams, which means there should be no excuses for the offense to perform at a level below average.
On the defensive front, the Cardinals are expected to be strong with players like Josh Sweat, Dalvin Tomlinson, and Calais Campbell. The secondary has uncertainties regarding youth and depth, but Budda Baker and Jalen Thompson are reliable safeties who can maintain stability until younger players develop. With a healthy and consistent Murray, along with an upgraded defense, the Cardinals could aim for a rare playoff position.
Cardinals vs Chiefs Prediction
I am considering the Over. Naturally, my attention is directed towards the quarterback depth during the preseason, and we have two competent backups receiving significant playing time. Gardner Minshew and Jacoby Brissett have both experienced success as starting quarterbacks, and they are now up against second and third-string defenses. Additionally, Bailey Zappe had notable performances a couple of years back with the Patriots. We can expect to witness some scoring drives and points with these established quarterbacks on the field. Therefore, I will back Over this Saturday night.
