Cardinals vs Panthers Prediction 9/14/25 NFL Picks Today

The Carolina Panthers and Arizona Cardinals meet Sunday in NFL action at State Farm Stadium. Here’s a Cardinals vs Panthers Prediction. This article will include a Cardinals vs Panthers Pick.

Carolina Panthers Betting Preview

The Carolina Panthers lost to the Jaguars, and they play the Falcons and Patriots next. The Carolina Panthers have lost 6 of their last 8 games. Bryce Young is completing 51.4 percent of his passes for 154 yards, 1 touchdown, and 2 interceptions. Tetairoa McMillan and Chuba Hubbard have combined for 100 receiving yards and 1 touchdown, while Ja’Tavion Sanders has 2 receptions.

The Carolina Panthers ground game is averaging 113 yards per contest, and Chuba Hubbard leads the way with 57 yards on 16 carries. Defensively, Carolina is allowing 26 points and 378 yards per game. Tre’von Moehrig leads the Carolina Panthers with 11 tackles, Mike Jackson has 1 pass deflection and Jaycee Horn has 1 interception.

Arizona Cardinals Betting Preview

The Arizona Cardinals beat the Saints, and play the 49ers and Seahawks next. The Arizona Cardinals have split their last 6 games. Kyler Murray is completing 72.4 percent of his passes for 163 yards, 2 touchdowns, and 0 interceptions. Marvin Harrison Jr. and Trey McBride have combined for 132 receiving yards and 1 touchdown, while Tip Reiman has 1 reception.

The Arizona Cardinals ground game is averaging 146 yards per contest, and Trey Benson leads the way with 69 yards on 8 carries. Defensively, Arizona is allowing 13 points and 315 yards per game. Budda Baker leads the Arizona Cardinals with 10 tackles, Baron Browning has 1 sack and Will Johnson has 3 pass deflections.

Carolina Panthers @ Arizona Cardinals Betting Trends: Week 2

Why the Arizona Cardinals will win

• The Panthers have lost each of their last eight road games before a Division game.
• The Cardinals have won seven of their last eight Week 2 home games.
• The Panthers have failed to cover the spread in seven of their last eight games as road underdogs before a Division game.
• The Cardinals have covered the spread in each of their last four home games against teams that held a losing record.
• The Cardinals have scored the first touchdown in each of their last eight Sunday games as home favorites.
• The Panthers have lost the first half in each of their last 13 games following a road loss.
• The home team has won the first quarter in five of the Cardinals’ last six Week 2 games.

Why the Carolina Panthers will win

• The Cardinals have lost each of their last six games as home favorites before a Division game.
• The underdogs have won each of the last five games between the Panthers and Cardinals.
• The Cardinals have failed to cover the spread in each of their last six games as home favorites before a Division game.
• The Panthers have covered the spread in seven of their last eight games against the Cardinals.
• The Panthers have won the first half in each of their last 11 Sunday games against the Cardinals.
• The Cardinals have lost the first quarter in four of their last five games as favorites against NFC South opponents.
• The Panthers have scored the first touchdown in seven of their last eight games against the Cardinals.

Total Points Facts

• Eight of the Cardinals’ last nine games as home favorites have gone OVER the total points line.
• Each of the Panthers’ last five games against the Cardinals following a loss have gone OVER the total points line.
• Each of the last three Sunday games at State Farm Stadium have gone OVER the total points line.

Arizona Cardinals Player Prop Facts

• James Conner has scored at least one touchdown in each of his last six appearances against teams with a losing record.
• James Conner has recorded 113+ rushing and receiving yards in each of his last six home appearances.
• Kyler Murray has recorded 266+ passing yards in each of his five previous Week 2 appearances.
• Michael Wilson has recorded 31+ receiving yards in each of the Cardinals’ last five September home games.
• James Conner has recorded 90+ rushing yards in each of his last five appearances with the Cardinals as home favorites.
• Kyler Murray has recorded 22+ completions in each of the Cardinals’ last six games played on the West Coast.
• Heading into Week 2, James Conner ranks T1st amongst qualified players for catch rate (100.0%) this season.

Carolina Panthers Player Prop Facts

• Chuba Hubbard has scored at least one touchdown in six of his last seven appearances with the Panthers as underdogs.
• Rico Dowdle has recorded 51+ rushing and receiving yards in each of his last 13 regular season appearances against NFC opponents.
• Andy Dalton has recorded 262+ passing yards in four of his last five appearances against the Cardinals.
• David Moore has recorded 15+ receiving yards in each of his last four appearances with his team as an underdog against NFC West opponents.
• Rico Dowdle has recorded 46+ rushing yards in each of his last six road appearances against NFC opponents.
• Andy Dalton has recorded 26+ completions in each of his last four appearances against the Cardinals.
• Heading into Week 2, Bryce Young has thrown the equal-most interceptions in a single game this season (2 vs Jaguars, Week 1).

Matchup/League Facts

• Heading into Week 2, the Cardinals rank T1st in the NFL in Q1 win percentage (100.0) this season.
• Heading into Week 2, the Cardinals rank T1st in the NFL in Q2 win percentage (100.0) this season.
• Heading into Week 2, the Panthers rank T1st in the NFL in Q4 win percentage (100.0) this season.
• Heading into Week 2, the Panthers rank T1st in the NFL in H2 win percentage (100.0) this season.

Cardinals vs Panthers Prediction

It’s just one game, but the Panthers looked bad against a Jaguars team that’s not exactly a world beater. I’m getting flashbacks from the Panthers, who we have learned to love in recent years. It’s also not easy to start the season with two straight road games.

The Cardinals looked decent opening week, and the passing attack will come along with more reps. At home, we should see a more explosive Cards offense. The Panthers have covered 7 of their last 9 games as an underdog, but I’m still not excited to back them with confidence. I’ll take the Cardinals in a double-digit home win.