Cardinals vs Seahawks Prediction 11/9/25 NFL Picks Today

In this article, we will formulate a Cardinals vs Seahawks Prediction for this NFL Week 10 game on Sunday, November 9^th. Let’s take a look at the prediction for this NFL matchup.

Seattle Seahawks Preview

The Seattle Seahawks have a 6-2 record this season and are sitting first in the NFC West. They are 6-2 ATS, 5-3 in Over/Under and have a 2-2 home record and a 4-0 away record. The Seahawks are coming off a 38-14 away win against the Washington Commanders and will face the Rams, Titans and Vikings next.

Offensively, the Seahawks average 28.9 points per game, ranking 5th in the NFL, while defensively, they allow 18.8 points per game, which is 5th. Seattle averages 359.0 total yards per game (255.1 passing and 103.9 rushing), while allowing 303.9 total yards per game (85.9 rushing and 218.0 passing).

Sam Darnold leads the Seahawks with 2084 passing yards with 70.4% completed passes and 16 touchdowns. Kenneth Walker III leads the team in rushing yards with 472, while Jaxon Smith-Njigba has a team-high 58 receptions for 948 receiving yards, and four touchdowns. Defensively, Ernest Jones has a team-high 65 total tackles (31 of them solo), while Uchenna Nwosu leads the team in sacks, with 5.5. Ernest Jones leads the team with three interceptions.

Arizona Cardinals Preview

The Arizona Cardinals have a 3-5 record this season and are sitting fourth in the NFC West. They are 5-3 ATS, 4-4 in Over/Under and have a 1-3 home record and a 2-2 away record. The Cardinals are coming off a 27-17 away win against the Dallas Cowboys and will face the 49ers, Jaguars and Buccaneers next.

Offensively, the Cardinals average 22.5 points per game, ranking 19th in the NFL, while defensively, they allow 21.4 points per game, which is 11th. Arizona averages 314.0 total yards per game (202.5 passing and 111.5 rushing), while allowing 335.4 total yards per game (103.6 rushing and 231.8 passing).

Kyler Murray leads the Cardinals with 962 passing yards with 68.3% completed passes and six touchdowns. Trey Benson leads the team in rushing yards with 160, while Trey McBride has a team-high 52 receptions for 476 receiving yards, and five touchdowns. Defensively, Mack Wilson has a team-high 60 total tackles (34 of them solo), while Josh Sweat leads the team in sacks, with 7.0. Dadrion Taylor-Demerson leads the team with two interceptions.

Arizona Cardinals @ Seattle Seahawks Betting Trends: Week 10

Why the Seattle Seahawks will win

• The Cardinals have lost each of their last 11 games against opponents on a winning streak.
• The Seahawks have won each of their last eight games against the Cardinals.
• The Seahawks have covered the spread in seven of their last eight games against the Cardinals.
• The Cardinals have failed to cover the spread in four of their last five games at Lumen Field.
• The Seahawks have scored the first touchdown in eight of their last nine games played as favorites on the West Coast.
• The Cardinals have won the first quarter in each of their last two games as moderate underdogs (+3.5 to +7.0 points).
• The Seahawks have won the first half in each of their last eight games against the Cardinals.

Why the Arizona Cardinals will win

• The Cardinals have won each of their last four November games as road underdogs against NFC opponents.
• The Seahawks have lost four of their last five games as home favorites when playing with a rest advantage.
• The Cardinals have covered the spread in each of their last nine games as underdogs before a Division game.
• The Seahawks have failed to cover the spread in seven of their last eight home games when playing with a rest advantage.
• The Cardinals have scored the first touchdown in six of their last seven Sunday games played on the West Coast.
• The Cardinals have won the first quarter in seven of their last eight November games as underdogs.
• The road team has won the first half in each of the five previous Week 10 games between the Cardinals and Seahawks.

Total Points Facts

• Each of the Seahawks’ last six home games against the Cardinals have gone UNDER the total points line.
• Each of the Cardinals’ last six road games against NFC West opponents have gone UNDER the total points line.
• Four of the last five games between teams from the same division have gone OVER the total points line.

Seattle Seahawks Player Prop Facts

• Kenneth Walker III has recorded 81+ rushing and receiving yards in each of his six previous appearances against the Cardinals.
• Sam Darnold has recorded 242+ passing yards in six of his last seven appearances with his team as a favorite against NFC opponents.
• Kenneth Walker III has recorded 64+ rushing yards in each of his last five appearances with the Seahawks as favorites against NFC West opponents.
• Jaxon Smith-Njigba has scored a touchdown in each of the Seahawks’ last four games as home favorites.
• Zach Charbonnet has recorded 12+ receiving yards in each of his last 10 Sunday appearances with the Seahawks as favorites.
• Sam Darnold has recorded 20+ completions in each of his last five November appearances.
• Heading into Week 10, Jaxon Smith-Njigba ranks 1st in the NFL in receiving yards (948) this season.

Arizona Cardinals Player Prop Facts

• Jacoby Brissett has recorded 261+ passing yards in each of the Cardinals’ last three games.
• Kyler Murray has recorded 32+ rushing yards in each of the Cardinals’ last six games as underdogs against NFC West opponents.
• Kyler Murray has scored at least one touchdown in each of his last five November appearances with the Cardinals as underdogs.
• Elijah Higgins has recorded 12+ receiving yards in seven of the Cardinals’ last eight road games as moderate underdogs (+3.5 to +7.0 points).
• Kyler Murray has recorded 24+ completions in each of his five previous November appearances against NFC West opponents.
• Heading into Week 10, Greg Dortch ranks 2nd amongst qualified players for catch rate (93.8%) this season.

Matchup/League Facts

• Seahawks – four different players have recorded multi-touchdown games this season – equal-most in the NFL, heading into Week 10.
• Heading into Week 10, the Seahawks are the only team in the NFL to rank top 5 for both interceptions and sacks this season.
• Cardinals – four different players have recorded 50+ rushing yards in a game this season – equal-most in the NFL, heading into Week 10.
• Heading into Week 10, the Cardinals have suffered the most losses when leading after Q3 this season (4).

Cardinals vs Seahawks Prediction

The Seahawks have won their last 9 meetings against the Cardinals, including their last three in Seattle. Under is 4-1 in their last 5 meetings.

In this Cardinals vs Seahawks Prediction, the Seahawks are coming as -6.5-point home favorites, with the total set at 45.5 points. Both teams are coming into this matchup in opposite trajectories, as the Seahawks are 6-1 in their last 7 games, while the Cardinals are 1-5 in their last 6. Seattle has both a better offense and defense, ranking 5^th in the NFL in both categories and have been dominating Arizona in recent years. Take the Seattle Seahawks and lay the -6.5 points at home.