Cardinals vs Titans Prediction 10/5/25 NFL Picks Today

In this article we will formulate a Cardinals vs Titans prediction for this NFL game on Sunday, October 5th at State Farm Stadium in Glendale, Arizona. Let’s take a look at the prediction for this week 5 matchup.

Arizona Cardinals Betting Preview

The Arizona Cardinals are 2-2 this year after they lost to Seattle by a score of 23-20 in their last game. Arizona trailed 17-3 late in the third quarter, but they tied the game with 28 seconds left, before losing on a last second field goal. The Cardinals were out gained by a total of 384-253, went 6-15 on third downs, and lost the turnover battle by a margin of 2-1 in the game. Kyler Murray went 27-41 for 200 yards, two touchdowns, and two interceptions, while also rushing five times for 41 yards. Marvin Harrison Jr led the receivers with six receptions for 66 yards and one score, but did have plenty of other issues throughout the game. The Arizona defense recorded three sacks and nine tackles for loss in the defeat. 

In their first three games, Arizona defeated New Orleans by a score of 20-13 and Carolina by a score of 27-22, but did lose to San Francisco by a score of 16-15. The Cardinals are averaging 20.5 points per game with 164.8 passing yards and 105.8 rushing yards per game, while they are allowing 18.5 points against per game this season. Kyler Murray has completed 66.9% of his passes for 742 yards, six touchdowns, and three interceptions, while Trey McBride has caught 24 passes for 234 yards and one touchdown. Trey Benson has led the rushing attack with 29 carries for 160 yards this year. 

Tennessee Titans Betting Preview

The Tennessee Titans are 0-4 this season after they lost to Houston by a score of 26-0 last week. Tennessee trailed 6-0 at halftime and allowed 20 points in the fourth quarter for the blowout loss. The Titans were out gained by a total of 353-175, went 2-11 on third downs, and lost the turnover battle by a total of 1-0 in the game. Cam Ward went 10-26 for 108 yards and one interception, while Tony Pollard rushed 14 times for 64 yards. Elic Ayomanor led the Tennessee receivers with two receptions for 44 yards in the game. The Titans defense recorded two sacks and six tackles for loss in the defeat. 

In their first three games, Tennessee lost to Denver by a score of 20-12, the Rams by a score of 33-19, and Indianapolis by a score of 41-20. The Titans are averaging 12.8 points per game with 123.5 passing yards and 87.0 rushing yards per game, while they are allowing 30.0 points against per game this season. Cam Ward has completed 51.2% of his passes for 614 yards, two touchdowns, and two interceptions, while Elic Ayomanor has caught 12 passes for 151 yards and two scores. Tony Pollard has led the ground game with 261 yards and one touchdown over 68 carries this season. 

Why the Cardinals will beat the Titans

• The Titans have lost each of their last 10 games.
• Sean Murphy-Bunting’s team has won each of its last four games with him playing against Calvin Ridley.
• The Titans have failed to cover the spread in each of their last eight games following a road loss.
• The Cardinals have covered the spread in each of their last seven games against AFC opponents.
• The favorites have won the first half in each of the Cardinals’ last six games.
• The Titans have lost the first quarter in each of their last five games against NFC opponents.
• The Cardinals have scored the first touchdown in each of their last nine Sunday games as home favorites.

Why the Titans will beat the Cardinals

• The Titans have won each of their last six road games against NFC West opponents on a losing streak.
• The Cardinals have lost four of their last six games as favorites when playing with a rest advantage.
• The road team has covered the spread in each of the Cardinals’ last four games.
• The Cardinals have failed to cover the spread in six of their last seven home games when playing with a rest advantage.
• The Cardinals have lost the first quarter in four of their last five games as home favorites against AFC opponents.
• The Titans have won the first half in five of their last six October games against NFC opponents.

Total Points Facts

• Each of the Cardinals’ last seven games as favorites following a loss have gone OVER the total points line.
• Each of the last four Sunday games at State Farm Stadium have gone OVER the total points line.
• Four of the Titans’ last five games against NFC opponents have gone OVER the total points line.

Arizona Cardinals Player Prop Facts

• Marvin Harrison Jr. has scored a touchdown in each of the Cardinals’ last two games against teams on a losing streak.
• Kyler Murray has recorded 224+ passing yards in seven of the Cardinals’ last eight games as favorites against AFC opponents.
• Trey McBride has recorded 65+ receiving yards in each of the Cardinals’ last five Sunday home games.
• Kyler Murray has recorded 32+ rushing yards in each of the Cardinals’ last four games.
• Kyler Murray has recorded 23+ completions in each of the Cardinals’ last six games following a loss.
• Heading into Week 5, Josh Sweat ranks T2nd in the league for forced fumbles (2) this season.

Tennessee Titans Player Prop Facts

• Tyler Lockett has scored at least one touchdown in five of his last six appearances at State Farm Stadium.
• Tyler Lockett has recorded 24+ receiving yards in each of his last 13 October road appearances.
• Heading into Week 5, Chimere Dike ranks 1st in the NFL in kick return yards (530) this season.

Matchup/League Facts

• Heading into Week 5, the Cardinals rank T1st in the NFL in 4th down percentage (100.0%) this season.
• Heading into Week 5, the Cardinals rank T1st in the NFL in Q3 win percentage (75.0) this season.
• Heading into Week 5, the Titans rank 32nd in the NFL in points per game (12.8) this season.
• Heading into Week 5, the Titans rank 32nd in the NFL in passing yards per game (123.5) this season.

Cardinals vs Titans Prediction 

Tennessee battled Denver very hard in their first game of the season, but it has gone downhill from there, as they have lost by margins of 14, 21, and 26 in their last three games. The Titans are really struggling to move the football and they are not helping their defense out at all. Arizona has lost two heartbreaking games in the last two weeks, but they should get their offense going here. I am not sold on the Arizona defense and I think the Titans will finally find some success, while the Cardinals will score nearly 30 points. Take the over in this one. 

David Racey is 15-3 (83%) in the NFL over the last two weeks and he has been red hot this season. Click here for his premium plays for this week!