Chargers vs Commanders Prediction 10/5/25 NFL Picks Today
Washington Commanders (2-2) vs. LA Chargers (3-1)
October 5, 2025 4:25 pm EDT
The Line: LA Chargers -2.5; Over/Under: 48.5
(Get latest betting odds)
The Washington Commanders and Los Angeles Chargers meet Sunday in NFL action at SoFi Stadium. Here’s a Chargers vs Commanders Prediction. This article will include a Chargers vs Commanders Pick.
Washington Commanders Betting Preview
The Washington Commanders beat the Raiders, lost to the Falcons, and they play the Bears next. The Washington Commanders have won 7 of their last 9 regular season games. Jayden Daniels is completing 59.7 percent of his passes for 433 yards, 3 touchdowns, and 0 interceptions. Deebo Samuel and Terry McLaurin have combined for 353 receiving yards and 2 touchdowns, while Zach Ertz has 14 receptions.
The Washington Commanders ground game is averaging 154.8 yards per contest, and Jacory Croskey-Merritt leads the way with 172 yards and 2 touchdowns. Defensively, Washington is allowing 22.8 points and 356 yards per game. Bobby Wagner leads the Washington Commanders with 42 tackles, Dorance Armstrong has 3 sacks and Mike Sainristil has 1 interception.
Los Angeles Chargers Betting Preview
The Los Angeles Chargers beat the Broncos, lost to the Giants, and they play the Dolphins next. The Los Angeles Chargers have won 6 of their last 7 regular season games. Justin Herbert is completing 63.8 percent of his passes for 1,063 yards, 7 touchdowns, and 3 interceptions. Quentin Johnston and Keenan Allen have combined for 568 receiving yards and 7 touchdowns, while Ladd McConkey has 16 receptions.
The Los Angeles Chargers ground game is averaging 107.3 yards per contest, and Omarion Hampton leads the way with 270 yards and 2 touchdowns. Defensively, Los Angeles is allowing 17.8 points and 270 yards per game. Derwin James Jr. leads the Los Angeles Chargers with 34 tackles, Tuli Tuipulotu has 4 sacks and Donte Jackson has 1 interception.
Washington Commanders @ Los Angeles Chargers Betting Trends: Week 5
Why the Los Angeles Chargers will win
- The Commanders have lost each of their last seven October games against AFC West opponents.
- The home team has won each of the Commanders’ last five games.
- The favorites have covered the spread in eight of the Chargers’ last nine games at SoFi Stadium.
- The Commanders have failed to cover the spread in seven of their last eight October games as underdogs against AFC opponents.
- The Commanders have lost the first half in each of their last seven road games following a road loss.
- The home team has won the first quarter in each of the Commanders’ last eight games.
- The Chargers have scored the first touchdown in six of their last eight games against NFC East opponents.
Why the Washington Commanders will win
- The Chargers have lost three of their last four games as favorites against NFC opponents.
- The Commanders have won each of their last two games as underdogs against AFC West opponents.
- The Commanders have covered the spread in seven of their last eight road games against AFC opponents.
- The Chargers have failed to cover the spread in three of their last four games as favorites against NFC opponents.
- The underdogs have won the first half in each of the Chargers’ last four Week 5 games.
- The Commanders have won the first quarter in each of their last six games following a loss.
- The Commanders have scored the first touchdown in each of their last six games following a loss.
Total Points Facts
- Each of the Commanders’ last eight games against AFC opponents have gone OVER the total points line.
- Each of the Chargers’ last four home games in October have gone UNDER the total points line.
- Each of the last three Sunday games at SoFi Stadium have gone UNDER the total points line.
Los Angeles Chargers Player Prop Facts
- Quentin Johnston has recorded 69+ rushing and receiving yards in each of the Chargers’ last five regular season games.
- Quentin Johnston has scored at least one touchdown in each of his last three appearances with the Chargers as favorites against NFC opponents.
- Justin Herbert has recorded 279+ passing yards in each of the Chargers’ last four October games as favorites against NFC opponents.
- Justin Herbert has recorded 24+ rushing yards in four of the Chargers’ last five regular season games.
- Keenan Allen has recorded 49+ receiving yards in each of his last eight appearances with the Chargers as favorites following a loss.
- Justin Herbert has recorded 22+ completions in each of the Chargers’ last six games against NFC East opponents.
- Heading into Week 5, Quentin Johnston ranks T1st in the NFL in 20+ yard receiving touchdowns (3) this season.
Washington Commanders Player Prop Facts
- Terry McLaurin has recorded 53+ receiving yards in each of the Commanders’ last seven October games.
- Deebo Samuel has scored the last touchdown in three of the Commanders’ last four games.
- Deebo Samuel has recorded 98+ rushing and receiving yards in each of his four previous appearances at SoFi Stadium.
- Terry McLaurin has scored two touchdowns in three of his last four Sunday regular season road appearances.
- Terry McLaurin has scored at least one touchdown in each of his last seven Sunday road appearances.
- Jayden Daniels has recorded 233+ passing yards in each of his last five Sunday appearances with the Commanders as underdogs.
- Deebo Samuel has recorded 13+ rushing yards in each of his last five appearances following a loss.
- Jayden Daniels has recorded 22+ completions in each of his last eight appearances with the Commanders as underdogs.
- Heading into Week 5, Jacory Croskey-Merritt ranks 2nd amongst qualified players for Yards Per Carry (5.9) this season.
Matchup/League Facts
- Chargers – one different players have recorded 100+ rushing yards in a game this season – equal-most in the NFL, heading into Week 5.
- Heading into Week 5, the Chargers rank T1st in the NFL in Q1 win percentage (75.0) this season.
- Commanders – four different players have recorded 50+ rushing yards in a game this season – most in the NFL, heading into Week 5.
- Commanders – three different players have recorded 60+ rushing yards in a game this season – equal-most in the NFL, heading into Week 5.
Chargers vs Commanders Prediction
The Chargers are coming off an ugly loss to the Giants, and you know they’re going to be motivated to get a nasty taste out of their mouth. The Commanders have defensive issues that make them hard to trust week to week, and the offense has concerns when you still see Daniels and McLaurin on the injury report. Marcus Mariota just isn’t cutting it in the big 2025.
The Chargers have offensive line issues and aren’t as good as many think, but this is a nice spot where they should get back on track. It’s a rebound game at home against a banged up Commanders squad. I’ll lay the small number.