Colts vs Broncos Prediction 9/14/25 NFL Picks Today

Denver Broncos (1-0) vs. Indianapolis Colts (1-0)
September 14, 2025 4:05 pm EDT
The Line: Indianapolis Colts +1.5; Over/Under: 43.5
(Get latest betting odds)

In this article we will formulate a Colts vs Broncos prediction for this NFL game on Sunday, September 14th at Lucas Oil Stadium in Indianapolis, Indiana. Let’s take a look at the prediction for this week 2 matchup.

Indianapolis Colts Betting Preview

The Indianapolis Colts are 1-0 this year after they defeated Miami by a score of 33-8 in their first game. Indianapolis led 3-0 after the first quarter and 20-0 at halftime, before cruising to the blowout win in the second half. The Colts out gained Miami by a total of 418-211, went 7-15 on third downs, and won the turnover battle by a margin of 3-0 in the game. Daniel Jones went 22-29 for 272 yards and one touchdown, while Michael Pittman Jr caught six passes for 80 yards and one score. Jonathan Taylor was the leading rusher for Indianapolis with 18 carries for 71 yards in the win. The Indy defense was led by Nick Cross and Charvarius Ward, who both had six tackles, while the team had three sacks and four tackles for loss.

Indianapolis got off to a great start this season with an easy win last week against Miami. The Colts dominated the entire game and held the ball for 38:43. Indianapolis had some question marks coming into the season around their quarterback situation, but Jones was fantastic in his debut. It obviously helped that Miami had no interest in competing, but it was a very solid start for the Colts.

Denver Broncos Betting Preview

The Denver Broncos are 1-0 this season after they defeated Tennessee by a score of 20-12 last week. Denver was tied at three after the first quarter, but they led by just one point at the half. The Broncos trailed 12-10 early in the third quarter, but they scored the last 10 points to escape with the victory. Denver out gained Tennessee by a total of 317-133, went 6-15 on third down conversions, and lost the turnover battle by a total of 4-2 in the win. Bo Nix went 25-40 for 176 yards, one touchdown, and two interceptions, while RJ Harvey rushed six times for 70 yards. Courtland Sutton led the Denver receivers with six catches for 61 yards and one touchdown, while Troy Franklin caught four passes for 44 yards in the win. The Denver defense was led by Talanoa Hufanga, who had 11 total tackles in the game, while the team had six sacks and seven tackles for loss.

Denver dominated the total yardage in their win over Tennessee, but they had issues with turnovers and were actually losing in the second half. The Broncos need to clean some things up in practice this week, but the defense had plenty of pressure on the quarterback and held Tennessee to just 2-14 on third downs. Denver also benefitted from 13 penalties for 131 yards on the Titans in the win.

Why the Broncos will beat the Colts

The favorites have won each of the Broncos’ last 15 games.
The Colts have lost five of their last six Week 2 home games.
The Broncos have covered the spread in nine of their last 10 games as favorites.
The Colts have failed to cover the spread in seven of their last eight home games against AFC West opponents.
The Broncos have won the first quarter in each of their last three Sunday games against teams that held a winning record.
The favorites have won the first half in each of the Broncos’ last four games.
The Broncos have scored the first touchdown in four of their last five games.

Total Points Facts

Each of the Broncos’ last six games as favorites following a win have gone OVER the total points line.
Six of the Colts’ last seven games against AFC opponents have gone OVER the total points line.

Indianapolis Colts Player Prop Facts

Anthony Richardson has scored at least one touchdown in each of his last four appearances against AFC opponents.
Daniel Jones has recorded 236+ passing yards in four of his five previous September appearances against AFC opponents.
Anthony Richardson has recorded 46+ rushing yards in each of his last four appearances.
Jonathan Taylor has recorded 111+ rushing and receiving yards in four of the Colts’ last five games.
Josh Downs has recorded 48+ receiving yards in seven of his last eight appearances with the Colts as underdogs against AFC opponents.
Daniel Jones has recorded 22+ completions in seven of his last eight appearances following a win.
Heading into Week 2, Daniel Jones ranks T1st in the NFL in touchdowns (2) this season.

Denver Broncos Player Prop Facts

Courtland Sutton has scored a touchdown in each of the Broncos’ last four games against teams on a winning streak.
J.K. Dobbins has scored the last touchdown in three of his last four regular season appearances with his team as a favorite.
Bo Nix has recorded 273+ passing yards in three of the Broncos’ last four games as favorites following a win.
Bo Nix has recorded 18+ rushing yards in each of the Broncos’ last six games.
J.K. Dobbins has recorded 75+ rushing and receiving yards in each of his last four regular season road appearances against AFC opponents.
Courtland Sutton has recorded 60+ receiving yards in each of the Broncos’ last six Sunday road games.
Bo Nix has recorded 24+ completions in each of the Broncos’ last four regular season games.
Heading into Week 2, J.K. Dobbins ranks T1st in the NFL in broken tackles (3) this season.

Matchup/League Facts

Colts – one different players have recorded multi-touchdown games this season – equal-most in the NFL, heading into Week 2.
Colts – two different players have recorded 70+ receiving yards in a game this season – equal-most in the NFL, heading into Week 2.
Broncos – two different players have recorded 50+ rushing yards in a game this season – equal-most in the NFL, heading into Week 2.
Broncos – two different players have recorded 60+ rushing yards in a game this season – equal-most in the NFL, heading into Week 2.