Colts vs Titans Prediction 10/26/25 NFL Picks Today

The Tennessee Titans and Indianapolis Colts meet Sunday in NFL action at Lucas Oil Stadium. Here’s a Colts vs Titans Prediction. This article will include a Colts vs Titans Pick.

Tennessee Titans Betting Preview

The Tennessee Titans lost to the Raiders and Patriots, and they play the Chargers next. The Tennessee Titans have lost 6 of their last 7 games. Cam Ward is completing 57.6 percent of his passes for 1,356 yards, 4 touchdowns, and 5 interceptions. Calvin Ridley and Elic Ayomanor have combined for 545 receiving yards and 2 touchdowns, while Chig Okonkwo has 23 receptions.

The Tennessee Titans ground game is averaging 75.7 yards per contest, and Tony Pollard leads the way with 380 yards and 2 touchdowns. Defensively, Tennessee is allowing 27.4 points and 349.6 yards per game. Cedric Gray leads the Tennessee Titans with 70 tackles, Jeffery Simmons has 4.5 sacks and Cody Barton has 2 interceptions.

Indianapolis Colts Betting Preview

The Indianapolis Colts beat the Cardinals and Chargers, and they play the Steelers next. The Indianapolis Colts have won 3 straight games. Daniel Jones is completing 71 percent of his passes for 1,790 yards, 10 touchdowns, and 3 interceptions. Tyler Warren and Micheal Pittman Jr. have combined for 790 receiving yards and 8 touchdowns, while Alex Pierce has 16 receptions.

The Indianapolis Colts ground game is averaging 130.1 yards per contest, and Jonathan Taylor leads the way with 697 yards and 10 touchdowns. Defensively, Indianapolis is allowing 20 points and 345.7 yards per game. Nick Cross leads the Indianapolis Colts with 53 tackles, Tyquan Lewis has 3 sacks and Mekhi Blackmon has 2 interceptions.

Why the Indianapolis Colts will win

• The Titans have lost each of their last 10 games against AFC opponents.
• The Colts have won each of their last eight home games against AFC opponents on a losing streak.
• The Colts have covered the spread in each of their last seven October games against AFC opponents.
• The Titans have failed to cover the spread in each of their last six games against AFC South opponents.
• The home team has won the first quarter in each of the Titans’ last four games.
• The Colts have scored the first touchdown in seven of their last eight games.
• The Titans have lost the first half in each of their last nine games against AFC opponents.

Why the Tennessee Titans will win

• The underdogs have won four of the Titans’ last five games at Lucas Oil Stadium.
• The Colts have lost each of their last two Week 8 games as favorites.
• The road team has covered the spread in each of the Colts’ last 10 Week 8 games.
• The Colts have failed to cover the spread in each of their last five Week 8 home games.
• The Colts have lost the first quarter in each of their last four October games as favorites against AFC opponents.
• The Colts have lost the first half in four of their last five Week 8 home games.

Total Points Facts

• Seven of the Colts’ last eight games as favorites against the Titans have gone OVER the total points line.
• Each of the Titans’ last five October games against AFC South opponents have gone UNDER the total points line.

Indianapolis Colts Player Prop Facts

• Tyler Warren has scored the first touchdown in three of the Colts’ last four games.
• Jonathan Taylor has scored two or more touchdowns in four of the Colts’ last five games against teams on a losing streak.
• Daniel Jones has recorded 22+ completions in nine of his last 10 appearances following a win.
• Daniel Jones has recorded 19+ rushing yards in 13 of his last 14 appearances with his team as a favorite.
• Michael Pittman Jr. has recorded 63+ receiving yards in eight of the Colts’ last nine games as favorites following a win.
• Jonathan Taylor has recorded 180+ rushing and receiving yards in three of the Colts’ last four home games against AFC South opponents.
• Jonathan Taylor has scored at least one touchdown in each of his eight previous appearances with the Colts as home favorites against teams on a losing streak.
• Jonathan Taylor has scored the last touchdown in each of the Colts’ last three games as favorites.
• Heading into Week 8, Jonathan Taylor ranks 1st in the NFL in rushing yards (697) this season.

Tennessee Titans Player Prop Facts

• Tyjae Spears has scored at least one touchdown in each of his last three appearances following a home loss.
• Cam Ward has recorded 21+ completions in four of the Titans’ last five games.
• Cam Ward has recorded 219+ passing yards in four of the Titans’ last five games.
• Tyjae Spears has recorded 18+ receiving yards in each of his last four appearances with the Titans as underdogs against AFC opponents.
• Tyjae Spears has recorded 27+ rushing yards in each of his last five road appearances against AFC opponents.
• Tyjae Spears has recorded 39+ rushing and receiving yards in each of his last six appearances with the Titans as underdogs against AFC opponents.
• Heading into Week 8, Chimere Dike ranks 1st in the NFL in kick return yards (816) this season.

Matchup/League Facts

• Colts – seven different players have recorded 50+ receiving yards in a game this season – equal-most in the NFL, heading into Week 8.
• Colts – three different players have recorded 2.0 sacks or more in a game this season – equal-most in the NFL, heading into Week 8.
• Heading into Week 8, the Titans rank 32nd in the NFL in points per game (13.7) this season.
• Heading into Week 8, the Titans rank 32nd in the NFL in yards per game (235.6) this season.

Colts vs Titans Prediction

This is the first time the Colts have been a double-digit favorite since January 9, 2022, a game they outright lost to the Jaguars. It’s also the first time this season the Titans have been a double-digit underdog. With that said, I’m laying the points with the Colts. The Titans are awful on both sides of the ball and 2-5 ATS on the season. The Colts are not only winning, but they’re 5-2 ATS on the season.

This Colts’ offense will have a field day against a bad Titans defense, while the Colts run defense will force Ward to make plays through the air. He hasn’t proven he can do that yet on the NFL level. Big line, but expect a blowout win from the Colts at home.