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Giants vs Cardinals Prediction 10/4/26 NFL Picks Today

Arizona Cardinals (1-2) vs. NY Giants (2-1)
October 4, 2026 1:00 pm EDT
The Line: NY Giants +2.5; Over/Under: 44.5
(Get latest betting odds)

The Arizona Cardinals and New York Giants meet Sunday in NFL action at MetLife Stadium. Here’s a Giants vs. Cardinals Prediction. This article will include a Giants vs. Cardinals Pick.

Arizona Cardinals Betting Preview

The Arizona Cardinals lost to the Seahawks and 49ers, and play the Lions next. The Arizona Cardinals have lost 11 of their last 12 games. Jacoby Brissett is completing 70.1 percent of his passes for 652 yards, 4 touchdowns, and 1 interception. Trey McBride and Michael Wilson have combined for 374 receiving yards and 3 touchdowns, while Kendrick Bourne has 12 receptions.

The Arizona Cardinals’ ground game is averaging 93 yards per contest, and Jeremiyah Love leads the way with 160 yards and 1 touchdown. Defensively, Arizona is allowing 27 points and 362 yards per game. Jack Gibbens leads the Arizona Cardinals with 24 tackles, Budda Baker has 1.5 sacks, and Andrew Wingard has 1 interception.

New York Giants Betting Preview

The New York Giants beat the Titans, lost to the Rams, and they play the Commanders next. The New York Giants have won 4 of their last 5 games. Jameis Winston is completing 51 percent of his passes for 229 yards, 0 touchdowns, and 1 interception. Isaiah Likely and Malik Nabers have combined for 220 receiving yards and 2 touchdowns, while Darnell Mooney has 6 receptions.

The New York Giants’ ground game is averaging 118.3 yards per contest, and Cam Skattebo leads the way with 177 yards and 1 touchdown. Defensively, New York is allowing 18.3 points and 329 yards per game. Arvell Reese leads the New York Giants with 25 tackles, Abdul Carter has 1 sack, and Jevon Holland has 3 interceptions.

Why the New York Giants will win

  • The Cardinals have lost each of their last eight games against NFC opponents.
  • The Giants have won five of their last six games as underdogs without Jason Pinnock.
  • The Cardinals have failed to cover the spread in each of their last five games without Marvin Harrison Jr.
  • The Giants have covered the spread in each of their last four home games without Jason Pinnock.
  • The Cardinals have lost the first quarter in four of their last five Week 4 games as favorites.
  • The Giants have scored the first touchdown in seven of their last nine games as home underdogs.
  • The Cardinals have lost the first half in each of their last eight road games against teams that held a winning record.

Why the Arizona Cardinals will win

  • The Giants have lost each of their last 10 games against NFC opponents on a losing streak.
  • The road team has won seven of the last eight games between the Cardinals and Giants.
  • The Cardinals have covered the spread in each of their last seven road games against NFC East opponents.
  • The Giants have failed to cover the spread in 13 of their last 14 home games against NFC West opponents.
  • The Cardinals have won the first quarter in each of their last six games against the Giants.
  • The Cardinals have scored the first touchdown in each of their last seven games as favorites following a loss.
  • The Giants have lost the first half in 17 of their last 18 games against NFC West opponents.

Total Points Facts

  • Each of the Cardinals’ last eight games as favorites following a loss have gone OVER the total points line.
  • Eight of the Giants’ last nine home games in October have gone UNDER the total points line.

New York Giants Player Prop Facts

  • Darnell Mooney has recorded 36+ receiving yards in 16 of his last 17 October appearances against NFC opponents.
  • Jameis Winston has recorded 21+ completions in six of his seven previous appearances with his team as an underdog against NFC West opponents.
  • Najee Harris has recorded 31+ rushing yards in each of his 10 previous home appearances against NFC opponents.
  • Jameis Winston has recorded 220+ passing yards in six of his seven previous appearances with his team as an underdog against NFC West opponents.
  • Cameron Skattebo has scored at least one touchdown in four of his last five appearances with the Giants as underdogs.
  • Najee Harris has recorded 40+ rushing and receiving yards in each of his last 11 October appearances.
  • Heading into Week 4, Jevon Holland ranks T1st in the NFL in interceptions (3) this season.

Arizona Cardinals Player Prop Facts

  • Jacoby Brissett has recorded 243+ passing yards in eight of the Cardinals’ last nine road games.
  • Kendrick Bourne has recorded 33+ receiving yards in each of his last 11 regular season appearances against NFC East opponents.
  • Kendrick Bourne has recorded 33+ rushing and receiving yards in each of his last 11 regular season appearances against NFC East opponents.
  • James Conner has scored at least one touchdown in each of his last eight October appearances with his team as a favorite.
  • James Conner has recorded 55+ rushing yards in each of his last six appearances against NFC East opponents.
  • Heading into Week 4, Jacoby Brissett has recorded the most completions in a single game this season (38 vs. the 49ers, Week 3).

Matchup/League Facts

  • Giants – three different players have recorded 50+ rushing yards in a game this season – equal-most in the NFL, heading into Week 4.
  • Heading into Week 4, the Giants rank T1st in the NFL in 4th down percentage against (0.0%) this season.
  • Heading into Week 4, the Cardinals rank T1st in the NFL in 4th down percentage (100.0%) this season.
  • Heading into Week 4, the Cardinals have allowed an average of 31.0 points over their last five games – most in the league over that span.

Giants vs Cardinals Prediction

The Cardinals have come back to earth these last couple of weeks, and now they’re flying across the country for an early start with a team on a West Coast body clock. I get the Giants are down to their backup quarterback, but you can win games here and there with Winston. He just showed it.

The Giants’ defense has also been impressive, and you’re still kind of waiting for Brissett to turn into a pumpkin a bit. Watch that completion percentage drop a bit with a turnover or two. It’s coming eventually. I’ll grab the points in a game the Giants could win outright.

Randy Chambers's Free Pick: NY Giants +2.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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