Packers vs Lions Prediction 9/7/25 NFL Picks Today

The Detroit Lions and the Green Bay Packers meet Sunday in NFL action from Lambeau Field. This will be the regular-season opener for both teams. Here’s a Packers vs Lions prediction. We will look at this from a betting perspective and determine the best Packers vs Lions pick.

Detroit Lions Betting Preview

The Lions had a great regular season in 2024 and were the sentimental favorites to post a deep playoff run among the NFL faithful. Alas, Detroit fell short after a stellar 15-2 run, however. After securing their third straight winning season (the first time that’s happened since 1995) and winning another NFC North title, the Lions played the surprising Washington Commanders in the Divisional Playoffs. Detroit lost a shootout in that matchup, falling 45-31 in the end.

This year the Lions opened up their preseason campaign with a matchup versus the Los Angeles Chargers in the Hall of Fame Game. Detroit lost that one 34-7, but made up for it with a 17-10 win over the Falcons in their second outing. The Lions’ Kyle Allen went 7-of-8 for 120 yards and two scores in that one. Jackson Meeks caught one of the touchdowns among his three grabs for 78 yards. In their third appearance, Detroit played the Miami Dolphins. After going into the break with a seven-point lead, the Lions ended up falling 24-17. Allen was great again with 124 yards and two touchdowns on 14-of-17 throwing, and Jacob Saylors led the rush with 39 yards. Meeks led the receivers once again with seven catches for 93 yards and a touchdown in the loss.

In their preseason finale versus the Houston Texans, Detroit scored in the first quarter but didn’t make a dent again during a 26-7 loss. Isaac TeSlaa caught the lone TD among his two grabs for 41 yards.

Green Bay Packers Betting Preview

Over on the Packers’ side, they fought their way through a very competitive NFC North, eventually earning a 11-6 regular-season record last year. It was an improvement over 2023’s 9-8 run and earned Green Bay a Wild Card spot despite a third-place finish in the division. The Packers’ postseason hopes were dashed quickly however, as they took a loss to the eventual champion Eagles 22-10 in their opening playoffs appearance.

Moving on to 2025, Green Bay had some trouble with the New York Jets in their preseason opener. The Packers gave up points in every quarter during a 30-10 defeat. Malik Willis threw for 39 yards on 4-of-9 passing, while Amar Johnson led the rushing attack on seven carries for 67 yards and a TD. In game two versus the Colts, Green Bay fared better. The Packers put up 13 points in the final quarter during a 23-19 comeback win. Willis was 6-of-14 for 83 yards this time, and Israel Abanikanda topped the rushers on 12 carries for 43 yards and a score. Cornelius Johnson led the receivers with 41 yards off three receptions.

In game three versus the Seattle Seahawks, Green Bay jumped out to a 20-0 halftime lead but didn’t score again during a 20-7 victory. Both Taylor Elgersma (6-of-8; 33 yards) and Willis (3-of-6; 50 yards; interception) had a pass TD. Emmanuel Wilson led the rushers on eight carries for 38 yards in the win.

Why the Green Bay Packers will win

• The Packers have won each of their last 12 home openers.
• The Lions have lost each of their last six road openers against NFC North opponents.
• The Packers have covered the spread in each of their last six home openers.
• The Lions have failed to cover the spread in five of their last six September games as underdogs against NFC North opponents.
• The Packers have scored the first touchdown in nine of their last 10 games as favorites.
• The home team has won the first quarter in 11 of the Lions’ last 13 games.
• The favorites have won the first half in each of the Lions’ last six Week 1 games.

Why the Detroit Lions will win

• The Lions have won each of their last eight road games.
• The Packers have lost four of their last five games as home favorites against NFC North opponents.
• The Lions have covered the spread in each of their last nine games as underdogs against NFC North opponents.
• The Packers have failed to cover the spread in each of their last six games against NFC North opponents.
• The Lions have scored the first touchdown in each of their last eight road games against the Packers.
• The Lions have won the first quarter in seven of their last eight road openers as underdogs.
• The Lions have won the first half in each of their last nine games against NFC North opponents.

Total Points Facts

• Each of the Lions’ last six September games against NFC North opponents have gone OVER the total points line.
• Each of the last four September games between the Lions and Packers have gone OVER the total points line.
• Three of the last four games between NFC North teams have gone OVER the total points line.

Packers vs Lions Prediction

I’ll lean toward Green Bay at home, but you could make a case either way here. The Packers didn’t look great on offense versus Seattle in their last preseason game, logging just 206 yards (70 passing), 3.1 yards per play and 13 first downs. The defense made up for it though, holding the Seahawks to just nine first downs and 2-of-13 on third-down tries while scooping up four lost fumbles. Granted, it’s just preseason, but that makes 43 points scored over the last two games for the Packers. If Green Bay can get off to a good start on the scoreboard I can see them covering in the friendly confines of Lambeau.