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Indianapolis Colts vs Buffalo Bills Prediction 11-10-24 NFL Picks

Buffalo Bills (7-2) vs. Indianapolis Colts (4-5)
November 10, 2024 1:00 pm EDT
The Line: Indianapolis Colts +4.5; Over/Under: +47.5
(Get latest betting odds)

The Buffalo Bills and Indianapolis Colts meet Sunday in week 11 NFL action at Lucas Oil Stadium. Here’s an Indianapolis Colts vs Buffalo Bills Prediction. This article will include an Indianapolis Colts vs Buffalo Bills Pick.

Buffalo Bills Betting Preview

The Buffalo Bills beat the Seahawks and Dolphins, and they play the Chiefs next. The Bills have won 3 of their last 5 road games. Josh Allen is completing 54.1 percent of his passes for 2,001 yards, 17 touchdowns, and 2 interceptions. Khalil Shakir and Keon Coleman have combined for 888 receiving yards and 5 touchdowns, while Dalton Kincaid has 32 receptions.


The Buffalo Bills ground game is averaging 119.1 yards per contest, and James Cook leads the way with 496 yards and 7 touchdowns. Defensively, Buffalo is allowing 19.2 points and 333.3 yards per game. Dorian Williams leads the Buffalo Bills with 84 tackles, Greg Rousseau has 4.5 sacks and Ja’Marcus Ingram has 2 interceptions.

Indianapolis Colts Betting Preview

The Indianapolis Colts lost to the Texans and Vikings and play the Jets next. The Indianapolis Colts have won 3 straight home games. Joe Flacco is completing 64.4 percent of his passes for 895 yards, 7 touchdowns, and 2 interceptions. Alec Pierce and Josh Downs have combined for 846 receiving yards and 6 touchdowns, while Michael Pittman Jr. has 30 receptions.

The Indianapolis Colts ground game is averaging 121.3 yards per contest, and Jonathan Taylor leads the way with 502 yards and 5 touchdowns. Defensively, Indianapolis is allowing 21.4 points and 383.6 yards per game. Zaire Franklin leads the Indianapolis Colts with 95 tackles, DeForest Buckner has 3.5 sacks and Jaylon Jones has 2 interceptions.

Why the Buffalo Bills will win

  • The Colts have lost each of their last 10 games as moderate underdogs (+3.5 to +7.0 points).
  • The Bills have won each of their last six games against opponents on a losing streak.
  • The road team has covered the spread in eight of the Bills’ last nine Week 10 games.
  • The Colts have failed to cover the spread in four of their last five November home games against AFC opponents.
  • The Colts have lost the first half in eight of their last nine games as home underdogs following a loss.
  • The Colts have won the first quarter in four of their last five games as moderate underdogs (+3.5 to +7.0 points).

Indianapolis Colts Player Prop Facts

  • Jonathan Taylor has recorded 91+ rushing and receiving yards in each of his last seven November home appearances.
  • Jonathan Taylor has recorded 83+ rushing yards in each of his last seven November home appearances.
  • Jonathan Taylor has scored at least one touchdown in each of his seven previous appearances against AFC East opponents.
  • Josh Downs has recorded 66+ receiving yards in each of the Colts’ last four games as underdogs against AFC opponents.
  • Jonathan Taylor has scored the first touchdown in four of his last five Sunday home appearances.
  • Heading into Week 10, Alec Pierce ranks 1st amongst qualified players for Yards Per Reception (22.9) this season.

Buffalo Bills Player Prop Facts

  • Josh Allen has scored at least one touchdown in each of the Bills’ last four November road games.
  • Josh Allen has recorded 248+ passing yards in nine of the Bills’ last 10 games as favorites against AFC South opponents.
  • Josh Allen has recorded 38+ rushing yards in nine of the Bills’ last 10 November road games.
  • Dawson Knox has recorded 10+ receiving yards in each of his 14 previous Sunday appearances with the Bills as road favorites.
  • Curtis Samuel has recorded 19+ rushing and receiving yards in nine of his 10 previous November road appearances.
  • Josh Allen has thrown two or more touchdowns in each of the Bills’ last six games as favorites.
  • Josh Allen has recorded 23+ completions in five of the Bills’ last six road games against AFC South opponents.
  • Rasul Douglas is just one away from 20 career interceptions.

Matchup/League Facts

  • Heading into Week 10, the Colts rank T1st in the NFL in fumbles recovered (9) this season.
  • Heading into Week 10, the Colts rank 32nd in the NFL in time of possession per game (25:42) this season.
  • Heading into Week 10, the Bills rank T1st in the NFL in turnover differential (+11) this season.
  • Heading into Week 10, the Bills rank T1st in the NFL in 4th down percentage (100.0%) this season.

Indianapolis Colts vs Buffalo Bills Prediction

The Buffalo Bills are easily the better team and should be favored, but the Colts continue to compete, and they’ve had chances to win every game Flacco has played. It’s been announced that Flacco will be the starter for the remainder of the season. The Colts are 7-2 ATS on the season and have covered 6 of their last 7 games. Only the Commanders and Lions have been better at covering numbers than the Colts. At home, I’ll take a shot with the Colts and the points.

Randy Chambers's Free Pick: Indianapolis Colts +4.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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