Indianapolis Colts vs Houston Texans Prediction 9/27/26 NFL Picks Today
Houston Texans (0-2) vs. Indianapolis Colts (0-2)
September 27, 2026 1:00 pm EDT
The Line: Indianapolis Colts +1.5; Over/Under: 42.5
(Get latest betting odds)
The Houston Texans and the Indianapolis Colts meet in week 3 NFL action from Lucas Oil Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Texans vs. Indianapolis Colts prediction.
Houston Texans Recap
The Houston Texans come into this game looking to rebound from a 20-6 loss at the hands of the Cincinnati Bengals last time out to sit at 0-2 this season. After this game, Houston will head home for a game against the Dallas Cowboys.
Texans Searching For First W
C.J. Stroud has thrown for 627 yards, 2 touchdowns and 0 interceptions on 60.2% passing while David Montgomery leads Houston in rushing with 70 rushing yards and 2 touchdowns so far this season. Woody Marks sits behind Montgomery on the ground with 50 yards and 0 TDs. Dalton Schultz leads the Texans in receiving with 175 yards on 16 catches, while Jaylin Noel trails with 84 yards on 3 catches. On defense, Azeez Al-Shaair has a team-high 20 total tackles, while Will Anderson Jr. leads the unit with 1.5 sacks. Houston’s defense as a whole has combined for 7 sacks and 0 interceptions so far this season.
Indianapolis Colts Recap
The Indianapolis Colts come into this game looking to bounce back from their 33-30 loss to Kansas City last time out to sit at 0-2 this season. After this game, the Colts will head on the road for a game against the Washington Commanders.
Colts Lose Back-To-Back Games To Start Year
Daniel Jones has thrown for 376 yards, 2 touchdowns and 2 interceptions on 66.1% passing while Jonathan Taylor leads Indianapolis in rushing with 190 rushing yards and 4 touchdowns so far this season. Deon Burks sits behind Taylor on the ground with 14 yards and 0 TDs. Josh Downs leads the Colts in receiving with 109 yards on 9 catches, while Alec Pierce trails with 72 yards on 5 catches. On defense, Akeem Davis-Gaither has a team-high 22 total tackles, while DeForest Buckner leads the unit with 1.5 sacks. Indianapolis’s defense as a whole has combined for 4 sacks and 0 interceptions so far this season.
Houston Texans @ Indianapolis Colts Betting Trends: Week 3
Why the Indianapolis Colts will win
- The Colts have won each of their last nine home games against AFC opponents on a losing streak.
- The Texans have lost seven of their last eight road openers.
- The Colts have covered the spread in each of their last six Week 3 home games.
- The Texans have failed to cover the spread in nine of their last 10 games in September.
- The underdogs have won the first quarter in each of the last four games between the Texans and Colts.
- The Colts have scored the first touchdown in each of their last nine games as underdogs.
- The Colts have won the first half in seven of their last eight games at Lucas Oil Stadium against teams that held a losing record.
Why the Houston Texans will win
- The Colts have lost each of their last nine games.
- The Texans have won each of their last eight games against opponents on a losing streak.
- The road team has covered the spread in each of the Colts’ last six games.
- The Colts have failed to cover the spread in each of their last four home games.
- The road team has won the first quarter in eight of the last nine games between the Texans and Colts.
- The Texans have scored the first touchdown in each of their last six games as road favorites.
- The Colts have lost the first half in each of their last seven games as home underdogs following a road loss.
Total Points Facts
- Each of the Texans’ last six September games as favorites have gone UNDER the total points line.
- Each of the Colts’ last five September games as home underdogs have gone OVER the total points line.
- Five of the last six games between teams from the same division have gone UNDER the total points line.
Indianapolis Colts Player Prop Facts
- Daniel Jones has recorded 267+ passing yards in four of his five previous September home appearances against AFC opponents.
- Darius Slayton has recorded 16+ receiving yards in each of his last eight appearances against AFC opponents.
- Daniel Jones has recorded 20+ rushing yards in six of his seven previous Week 3 appearances.
- Daniel Jones has recorded 22+ completions in five of his last six September appearances with his team as an underdog.
- Anthony Richardson has scored at least one touchdown in four of his five previous appearances with the Colts as underdogs following a loss.
- Heading into Week 3, Akeem Davis-Gaither has played in the equal-most consecutive losses in the league (11).
Houston Texans Player Prop Facts
- David Montgomery has scored at least one touchdown in each of his last four appearances against AFC South opponents.
- C.J. Stroud has recorded 11+ rushing yards in each of the Texans’ last eight September games.
- C.J. Stroud has recorded 242+ passing yards in each of his last four appearances with the Texans as road favorites.
- David Montgomery has recorded 10+ receiving yards in eight of his last nine appearances against conference opponents.
- David Montgomery has recorded 61+ rushing and receiving yards in nine of his last 10 road appearances against AFC opponents.
- C.J. Stroud has recorded 22+ completions in each of the Texans’ last six September games against AFC opponents.
- Heading into Week 3, Dalton Schultz has recorded the most receptions in a single game this season (12 vs Bengals, Week 2).
Matchup/League Facts
- Heading into Week 3, the Colts rank 32nd in the NFL in points allowed per game (37.0) this season.
- Heading into Week 3, the Colts rank 32nd in the NFL in yards allowed per game (514.5) this season.
- Heading into Week 3, the Texans rank 1st in the NFL in 4th down attempts (6) this season.
- Heading into Week 3, the Texans rank T1st in the NFL in 4th down percentage against (0.0%) this season.
Houston Texans vs. Indianapolis Colts Prediction
I’m on the Colts in this one. The Texans just look broken right now and Indianapolis really impressed me with their fight against Kansas City last week. I just think getting back home with the healthier unit is going to play well for Indianapolis here so give me the Colts.