Chargers vs Broncos Prediction 9/21/25 NFL Picks Today

The Denver Broncos and the Los Angeles Chargers meet in week 3 NFL action from SoFi Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chargers vs Broncos Prediction.

Denver Broncos Recap

The Denver Broncos come into this game looking to rebound from a 29-28 loss at the hands of the Indianapolis Colts last time out to slip to 1-1 on the year. After this game, the Broncos will head home for a game against the Cincinnati Bengals.

Broncos Looking For Rebound Showing

Bo Nix has thrown for 382 yards, 4 touchdowns and 3 interceptions on 67.1% passing while JK Dobbins has rushed for 139 yards and 2 touchdowns on the ground. Troy Franklin leads Denver’s receiving group with 12 catches for 133 yards and a touchdown. On defense, Talanoa Hufanga has a team-high 21 total tackles while Justin Strnad has a pair of sacks and as a whole, Denver’s defense has combined for 7 sacks so far this season.

Why the Denver Broncos will win

• The Broncos have won each of their last seven Week 3 games against AFC West opponents.
• The Chargers have lost each of their last four Week 3 games as favorites.
• The Broncos have covered the spread in five of their last six road games following a loss.
• The Chargers have failed to cover the spread in five of their last six Week 3 games against AFC opponents.

Denver Broncos Player Prop Facts

• Courtland Sutton has scored a touchdown in six of the Broncos’ last seven games as underdogs against teams on a winning streak.
• Bo Nix has recorded 22+ completions in each of the Broncos’ last five regular season games.
• J.K. Dobbins has recorded 50+ rushing yards in each of his last eight Sunday appearances.
• J.K. Dobbins has recorded 62+ rushing and receiving yards in each of his last eight appearances against division opponents.
• Bo Nix has recorded 263+ passing yards in each of the Broncos’ last three games against AFC West opponents.
• J.K. Dobbins has scored the last touchdown in three of his last four regular season appearances against AFC opponents.
• Evan Engram has recorded 33+ receiving yards in five of his last six appearances with his team as an underdog.
• Heading into Week 3, Adam Trautman ranks T1st amongst qualified players for catch rate (100.0%) this season.

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to add on to their 20-9 win over the Las Vegas Raiders last time out to sit at 2-0 on the year. After this game, the Chargers will head on the road for a game against the New York Giants.

Chargers Looking To Remain Unbeaten

Justin Herbert has thrown for 560 yards and 5 touchdowns on 72.1% passing while Omarion Hampton leads Los Angeles in rushing with 72 rushing yards this season. Quentin Johnston has 150 receiving yards and 3 touchdowns to lead the Chargers’ group while Keenan Allen has 129 receiving yards and 2 touchdowns with 12 grabs and Ladd McConkey’s added 122 receiving yards as well. On defense, Daiyan Henley has a team-high 18 total tackles including 10 solo tackles and a pair of sacks while the Chargers’ defensive unit as a whole has combined for 5 sacks and 3 interceptions so far this season. 

Why the Los Angeles Chargers will win

• The Broncos have lost each of their last nine road games against AFC West opponents on a winning streak.
• The home team has won each of the Broncos’ last eight games.
• The Chargers have covered the spread in each of their last six games against AFC West opponents.
• The Broncos have failed to cover the spread in each of their last four road games.

Los Angeles Chargers Player Prop Facts

• Keenan Allen has scored at least one touchdown in six of his last seven appearances against division opponents.
• Justin Herbert has recorded 281+ passing yards in four of the Chargers’ last five regular season games.
• Justin Herbert has recorded 23+ completions in five of the Chargers’ last six September games as home favorites.
• Keenan Allen has recorded 63+ receiving yards in each of his 11 previous September appearances with the Chargers as home favorites.
• Najee Harris has recorded 19+ rushing yards in each of his last 22 appearances with his team as a favorite.
• Najee Harris has recorded 48+ rushing and receiving yards in each of his last 22 appearances with his team as a favorite.
• Heading into Week 3, Quentin Johnston ranks T1st in the NFL in touchdowns (3) this season.

Total Points Facts

• Each of the Chargers’ last six games against the Broncos following a road win have gone UNDER the total points line.
• Seven of the Broncos’ last eight road games against the Chargers following a loss have gone UNDER the total points line.
• Six of the last seven Sunday games at SoFi Stadium have gone OVER the total points line.

Chargers vs Broncos Prediction

I’m on the Chargers here. I just think that the Chargers have looked more impressive through two weeks. While I still think the Broncos have one of the best defensive units in the NFL, I don’t think there’s a huge drop-off when it comes to the Chargers. I think that Justin Herbert’s in really solid form right now to where I’m fine backing him in this spot at home. I’m concerned about a sophomore slump for Bo Nix, and I don’t know if this is a great spot for him either. Give me the Chargers here.