Arizona Cardinals (3-13) vs. LA Rams (11-5)
January 4, 2026 4:25 pm EDT
The Line: LA Rams -7.5; Over/Under: 46.5
(Get latest betting odds)
The Arizona Cardinals and the Los Angeles Rams meet in week 18 NFL action from SoFi Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Cardinals vs. Los Angeles Rams prediction.
Arizona Cardinals Recap
The Arizona Cardinals come into this game looking to shake off a 37-14 loss at the hands of Cincinnati last time out to sit at 3-13 this season.
Cardinals In Mix For #1 Draft Pick Amidst Disappointing Season
Jacoby Brissett has thrown for 3,123 yards, 21 touchdowns and 7 interceptions on 64.5% passing while Michael Carter has a team-high 315 rushing yards and Bam Knight has 269 rushing yards and 4 touchdowns. Emari Demercado also has 283 rushing yards while Trey McBride has 119 catches for 1,174 yards and 11 touchdowns and Marvin Harrison Jr. has 41 catches for 608 yards and 4 TDs. Michael Wilson has 73 catches for 907 yards and 6 TDs and another three Cardinals also have 200+ receiving yards as well this season. On defense, Akeem Davis-Gaither also has a team-high 112 total tackles while Josh Sweat has a team-high 11 sacks and Calais Campbell has 6.5 sacks. As a unit, Arizona’s defense has combined for 29 sacks and 10 interceptions so far this season.
Why the Arizona Cardinals will win
- The Cardinals have won five of their last six games as road underdogs when playing with a rest advantage.
- The Rams have lost six of their last seven home games against NFC West opponents on a losing streak.
- The Cardinals have covered the spread in each of their last six games as underdogs without Michael Carter.
- The Rams have failed to cover the spread in seven of their last eight games as home favorites against NFC West opponents.
Arizona Cardinals Player Prop Facts
- Emari Demercado has recorded 30+ rushing and receiving yards in three of his last four appearances against NFC opponents.
- Trey McBride has scored at least one touchdown in each of the Cardinals’ last eight games as road underdogs.
- Jacoby Brissett has recorded 271+ passing yards in three of the Cardinals’ last four games against NFC opponents.
- Michael Wilson has recorded 52+ receiving yards in seven of the Cardinals’ last eight games following a loss.
- Emari Demercado has recorded 30+ rushing yards in three of his last four appearances against NFC opponents.
- Jacoby Brissett has recorded 25+ completions in three of the Cardinals’ last four games against NFC opponents.
- Heading into Week 18, Trey McBride ranks T1st in the NFL in receptions (119) this season.
Los Angeles Rams Recap
The Los Angeles Rams come into this game looking to shake off a 27-24 loss at the hands of Atlanta last time out to sit at 11-5 this season.
Rams Drop Back-To-Back Games
Matthew Stafford has thrown for 4,448 yards, 42 touchdowns and 8 interceptions on 65.2% passing while Kyren Williams has rushed for 1,192 yards and 10 touchdowns to lead the Rams on the ground and Blake Corum has 687 rushing yards. Puka Nacua has a team-high 119 catches for 1,639 yards and 9 TDs while Davante Adams has 60 grabs for 789 yards and 14 touchdowns. Colby Parkinson has 39 catches for 372 yards and 6 touchdowns and seven more Rams have 150+ receiving yards as well this season. On defense, Nate Landman has a team-high 129 total tackles including 62 solo tackles. Byron Young has a team-high 11 sacks while the Rams’ defense as a whole has combined for 41 sacks and 15 interceptions so far this season.
Why the Los Angeles Rams will win
- The Cardinals have lost each of their last 12 Sunday games.
- The Rams have won each of their last eight Sunday games played on the West Coast.
- The Rams have covered the spread in each of their last seven Sunday games against teams that held a losing record.
- The Cardinals have failed to cover the spread in seven of their last eight games without Sean Murphy-Bunting.
Los Angeles Rams Player Prop Facts
- Colby Parkinson has scored at least one touchdown in each of the Rams’ last five games played as favorites on the West Coast.
- Matthew Stafford has recorded 273+ passing yards in each of the Rams’ last four games played on the West Coast.
- Puka Nacua has recorded 167+ receiving yards in each of the Rams’ last three games played on the West Coast.
- Puka Nacua has recorded 167+ rushing and receiving yards in each of the Rams’ last three games played on the West Coast.
- Matthew Stafford has recorded 24+ completions in each of the Rams’ last six home games as heavy favorites (>-7.0 points).
- Heading into Week 18, Matthew Stafford ranks 1st in the NFL in passing touchdowns (42) this season.
Total Points Facts
- Each of the Rams’ last six games as home favorites following a loss have gone UNDER the total points line.
- Each of the Cardinals’ last five road games without Michael Carter have gone UNDER the total points line.
- Six of the last seven games between NFC West teams have gone OVER the total points line.
Arizona Cardinals vs. Los Angeles Rams Prediction
I’m on the Rams here. Any positive result hurts the Cardinals’ draft positioning here, and the Rams can still help their playoff positioning with a win to try to get a better seed and more importantly, with the Wild Card on the horizon, the Rams want to get back on track. I think that the Rams take out the Cardinals in emphatic fashion here so give me Los Angeles.
