Las Vegas Raiders vs LA Chargers Prediction 9/15/25 NFL Picks Today

The Los Angeles Chargers and the Las Vegas Raiders meet in week 2 NFL action from Allegiant Stadium on Monday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Chargers vs. Las Vegas Raiders prediction.

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to add on to their 27-21 win over the Kansas City Chiefs last time out to start the year at 1-0. After this game, the Chargers will head home for their home opener against the Denver Broncos.

Chargers Looking To Continue Strong Start To Season

Justin Herbert threw for 318 yards and 3 touchdowns on 25 of 34 passing while also rushing for 32 yards on 7 carries. Omarion Hampton added a team-high 48 rushing yards on 15 carries while Quentin Johnston chipped in a team-high 5 catches for 79 yards and 2 touchdowns. Ladd McConkey added 6 grabs for 74 yards while Keenan Allen had a team-high 7 receptions for 68 yards and a touchdown. Tyler Conklin also added a pair of receptions for 50 yards as well. On defense, Alohi Gilman added 9 total tackles including 4 solo tackles while Daiyan Henley and Da’Shawn Hand each had a sack in the win for Los Angeles.

Why the Los Angeles Chargers will win

• The Chargers have won each of their last six games when playing with a rest advantage against the Raiders.
• The Raiders have lost each of their last six games against AFC West opponents.
• The favorites have covered the spread in each of the last six games between the Chargers and Raiders.
• The Raiders have failed to cover the spread in five of their last six home games against teams that held a winning record.

Los Angeles Chargers Player Prop Facts

• Quentin Johnston has scored the first touchdown in three of the Chargers’ last four September games.
• Keenan Allen has scored at least one touchdown in five of his last six appearances against division opponents.
• Justin Herbert has recorded 281+ passing yards in each of the Chargers’ last four regular season games.
• Ladd McConkey has recorded 58+ receiving yards in each of his last nine appearances.
• Ladd McConkey has recorded 58+ rushing and receiving yards in each of his last nine appearances.
• Najee Harris has recorded 65+ rushing yards in each of his last four regular season road appearances against AFC West opponents.
• Justin Herbert has recorded 23+ completions in each of the Chargers’ last four regular season games.
• Heading into Week 2, Quentin Johnston ranks T1st in the NFL in touchdowns (2) this season.

Las Vegas Raiders Recap

The Las Vegas Raiders come into this game looking to build on their 20-13 win over the New England Patriots last time out to start the year at 1-0. After this game, the Raiders will head on the road for a game against the Washington Commanders. 

Raiders Looking For Another Upset To Start Year

Geno Smith threw for 362 yards, a touchdown and an interception on 24 of 34 passing while Ashton Jeanty led the Raiders on the ground with 38 rushing yards and a score on his 19 carries. Brock Bowers led Las Vegas’ receiving group with 5 catches for 103 yards while Jakobi Meyers had a team-high 8 receptions for 97 yards and Tre Tucker had a pair of catches for 54 yards and a touchdown. On defense, Devin White had a team-high 11 total tackles including 8 solo tackles while Tyree Wilson, Malcolm Koonce, Maxx Crosby and Jonah Laulu all had a sack in the win. Isaiah Pola-Mao also chipped in an interception for the Raiders’ defense in the victory.

Why the Las Vegas Raiders will win

• The Chargers have lost each of their last seven Week 2 road games against AFC West opponents.
• The Raiders have won four of their last five Monday games as home underdogs.
• The Raiders have covered the spread in nine of their last 10 games when playing with a rest disadvantage.
• The Chargers have failed to cover the spread in each of their last four Monday games played on the West Coast.

Las Vegas Raiders Player Prop Facts

• Jakobi Meyers has scored at least one touchdown in six of his last seven home appearances against division opponents.
• Geno Smith has recorded 289+ passing yards in each of his last four September appearances.
• Raheem Mostert has recorded 82+ rushing yards in three of his last four regular season appearances against AFC West opponents.
• Jakobi Meyers has recorded 52+ receiving yards in each of the Raiders’ last seven games against AFC West opponents.
• Jakobi Meyers has recorded 59+ rushing and receiving yards in each of the Raiders’ last six games as underdogs.
• Geno Smith has recorded 23+ completions in each of his last five September appearances with his team as an underdog.
• Heading into Week 2, Devin White has recorded the equal-most solo tackles in a single game this season (8 vs Patriots, Week 1).

Total Points Facts

• Each of the Chargers’ last seven games as favorites have gone OVER the total points line.
• Each of the Raiders’ last six home games against AFC West opponents have gone OVER the total points line.
• Five of the last six games between teams from the same division have gone UNDER the total points line.

Los Angeles Chargers vs. Las Vegas Raiders Prediction

I’m on the Chargers here. It’s not a game I’m rushing to the window to bet, but between two teams that had a nice showing in their openers, I just feel like positive results are going to be easier for the Chargers to sustain given the pieces and makeup of their roster. The Raiders are a solid group and solid home team that I think will surprise some people and provide value at times this season, but with this only being week 2, I think we have to go with what we know and that to me ends up with backing the Chargers here. Give me Los Angeles laying the points here.