Giants vs Chiefs Prediction 9/21/25 NFL Picks Today

The Kansas City Chiefs and the New York Giants meet in week 3 NFL action from MetLife Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Giants vs Chiefs Prediction.

Kansas City Chiefs Recap

The Kansas City Chiefs come into this game looking to bounce back from their 0-2 start to the year after falling to the Philadelphia Eagles by a final score of 20-17 last time out. After this game, the Chiefs will head home for a matchup with the Baltimore Ravens.

Chiefs Looking For First W

Patrick Mahomes has thrown for 445 yards, 2 touchdowns and an interception on 58.8% passing while also leading the Chiefs in rushing with 123 yards and 2 touchdowns on the ground this season. Hollywood Brown leads Kansas City with 15 catches for 129 yards while Travis Kelce and Tyquan Thornton each have 100+ receiving yards and a touchdown so far this season. On defense, Chamarri Conner has a team-high 19 total tackles including 10 solo tackles while Drue Tranquill has a pair of sacks so far this season for Kansas City.

Why the Kansas City Chiefs will win

• The Chiefs have won each of their last 12 games following a home loss.
• The Giants have lost nine of their last 10 games against teams that held a losing record.
• The Giants have failed to cover the spread in 12 of their last 13 home openers.
• The Chiefs have covered the spread in nine of their last 10 road games following a home loss.

Kansas City Chiefs Player Prop Facts

• Kareem Hunt has scored at least one touchdown in each of his four previous September appearances with his team as a favorite against NFC opponents.
• Patrick Mahomes has recorded 245+ passing yards in each of the Chiefs’ last nine games following a home loss.
• Kareem Hunt has recorded 40+ rushing yards in each of his nine previous Sunday regular season appearances with the Chiefs as road favorites.
• Patrick Mahomes has recorded 24+ completions in 10 of the Chiefs’ last 11 regular season games as favorites.
• Noah Gray has recorded 18+ receiving yards in each of the Chiefs’ last six Sunday regular season games as favorites.
• Kareem Hunt has recorded 49+ rushing and receiving yards in each of his nine previous Sunday regular season appearances with the Chiefs as road favorites.
• Heading into Week 3, Patrick Mahomes ranks 1st amongst qualified players for Yards Per Carry (9.5) this season.

New York Giants Recap

The New York Giants come into this game looking to rebound from their 40-37 loss at the hands of the Dallas Cowboys last time out to sit at 0-2 this season. After this game, the Giants will take on the Los Angeles Chargers at home.

Giants Drop Heartbreaker To Remain Winless

Russell Wilson has thrown for 618 yards, 3 touchdowns and an interception on 60.3% passing while also leading the Giants with 67 rushing yards. Cam Skattebo also has 42 rushing yards with a touchdown while Malik Nabers leads the Giants with 14 catches for 238 yards and 2 touchdowns and Wan’Dale Robinson has 14 grabs for 197 yards and a TD. On defense, Bobby Okereke has a team-high 26 total tackles including 11 solo tackles while Paulson Adebo has 20 total tackles including a team-high 17 solo tackles. Brian Burns also leads the Giants with 3 sacks as well this season. 

Why the New York Giants will win

• The Giants have won each of their seven previous home games against the Chiefs.
• The Chiefs have lost each of their last two games as favorites.
• The Chiefs have failed to cover the spread in each of their last four games against NFC opponents.
• The home team has covered the spread in four of the Giants’ last five games.

New York Giants Player Prop Facts

• Malik Nabers has scored at least one touchdown in three of the Giants’ last four games.
• Russell Wilson has recorded 27+ rushing yards in each of his seven previous appearances against the Chiefs.
• Russell Wilson has recorded 298+ passing yards in each of his four previous September appearances with his team as an underdog against AFC opponents.
• Theo Johnson has recorded 34+ receiving yards in six of his last seven appearances.
• Jameis Winston has recorded 23+ completions in eight of his last 10 appearances as a starter.
• Heading into Week 3, Russell Wilson ranks 1st in the NFL in passing yards (618) this season.

Total Points Facts

• Each of the Giants’ last 11 home openers have gone UNDER the total points line.
• Each of the Chiefs’ last four Week 3 road games have gone UNDER the total points line.
• Three of the last four Sunday games at MetLife Stadium have gone OVER the total points line.

Giants vs Chiefs Prediction

I’m on the Giants and the points here. I just can’t trust the Chiefs right now with the shape this offense is in, and maybe a lot of preseason critics of KC were actually right with this Kansas City team. Furthermore, I know it’s important to not overreact two weeks into an 18-week season, but there are troubles with the Chiefs right now, and I’m not about to lay a touchdown with them on the road. Give me the points with the Giants.