LA Chargers (3-0) vs. NY Giants (0-3)
September 28, 2025 1:00 pm EDT
The Line: NY Giants +6; Over/Under: 44.5
(Get latest betting odds)
The Los Angeles Chargers and the New York Giants meet Sunday in NFL action from MetLife Stadium. Here’s a Giants vs Chargers prediction. We will look at this from a betting perspective and determine the best Giants vs Chargers pick.
Los Angeles Chargers Betting Preview
The Chargers got off to a good start this year, posting victories against rivals in their first two games. The opener was a matchup versus the Kansas City Chiefs, and Los Angeles managed to score in every quarter along the way to a 27-21 win. Los Angeles managed 394 total yards in the victory, with 304 of those coming through the air. In game two versus the Oakland Raiders, Los Angeles was able to keep it going. The Chargers jumped out to a 17-6 halftime lead and eventually won 20-9. This time LA mustered 317 total yards while holding Las Vegas to just 218 yards (150 passing) and 3.4 yards per play on the other side.
In last weekend’s matchup versus the Denver Broncos, the Chargers played a close one. Los Angeles was down 17-13 going into the final quarter, then closed on a 10-3 run to power out the win 23-20 in the end. QB Justin Herbert was 28-of-47 for 300 yards, one TD and one pick while Omarion Hampton led the rush on 19 carries for 70 yards and a score. Quentin Johnston logged six catches for 89 yards to top the receivers and Keenan Allen added seven catches for 65 yards and a touchdown.
New York Giants Betting Preview
Over on the Giants’ side, their year began with a matchup versus the Washington Commanders. New York could only find a couple of field goals in that one, limping to a 21-6 loss in the end. The Giants offense accounted for just 231 total yards (74 rushing) and 3.7 yards per play in the defeat. In game two versus the rival Dallas Cowboys, New York’s offense got a shot in the arm but still fell short. The result was a tight overtime loss 40-37. This time the Giants posted 506 yards (422 passing) and 7.8 yards per play but also committed 14 of the game’s 26 penalties, resulting in a loss of 160 yards for New York.
On Sunday versus the Chiefs, the Giants were within a field goal at halftime but eventually took a 22-9 loss, giving up points in every quarter along the way. QB Russell Wilson finished with 160 yards and two picks on 18-of-32 passing, and Cameron Skattebo had 10 carries for 60 yards and a touchdown. Skattebo also led the receivers with six grabs for 61 yards and Darius Slayton caught four passes for 30 yards as well.
Giants vs Chargers Prediction
I’m going with the Chargers, but I’m probably not touching this one. Los Angeles wasn’t spectacular in their win over Denver last weekend, but they get credit for the late surge. The Chargers ended up with 8-of-17 on third-down tries and a couple of turnovers on offense, gathering 376 total yards (270 passing) and 29 first downs along the way. Los Angeles’ defense was pretty good despite not generating a turnover, allowing 265 yards (147 passing), nine first downs and 2-of-13 on third-down conversions. Denver’s 10 penalties for 90 yards were helpful to the cause as well. LA hasn’t given up more than 21 points in any game yet this year, but they also haven’t scored more than 27 points in any game this year.
As for the Giants, they didn’t look too bad in the first half against Kansas City but eventually posted a couple of interceptions and a miserable 1-of-10 effort on third-down tries. New York has scored more than nine points exactly once in three games (37 versus the Cowboys) and they’ve given up at least 21 points in each outing. I can’t trust them to do anything right now.
