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Panthers vs Saints Prediction 12/14/25 NFL Picks Today

Carolina Panthers (7-6) vs. New Orleans Saints (3-10)
December 14, 2025 4:25 pm EDT
The Line: New Orleans Saints +2.5; Over/Under: 40.5
(Get latest betting odds)

In this article, we will formulate a Panthers vs Saints Prediction for this NFL Week 13 game on Sunday, December 14th. Let’s take a look at the prediction for this NFL matchup.

New Orleans Saints Preview

The New Orleans Saints have a 3-10 record this season and are sitting fourth in the NFC South. They are 5-8 ATS, 4-8-1 in Over/Under and have a 1-5 home record and a 2-5 away record. The Saints are coming off a 24-20 away win against the Tampa Bay Buccaneers and will face the Jets, Titans and Falcons next.

Offensively, the Saints average 15.8 points per game, ranking 30th in the NFL, while defensively, they allow 24.2 points per game, which is 21st. New Orleans averages 293.8 total yards per game (199.4 passing and 94.4 rushing), while allowing 313.5 total yards per game (130.9 rushing and 182.6 passing).

Spencer Rattler leads the Saints with 1586 passing yards with 68.0% completed passes and 8 touchdowns. Alvin Kamara leads the team in rushing yards with 471, while Chris Olave has a team-high 76 receptions for 811 receiving yards, and 5 touchdowns. Defensively, Demario Davis has a team-high 118 total tackles (57 of them solo), while Cameron Jordan leads the team in sacks, with 6.5, while Kool-Aid McKinstry leads the team with 3 interceptions.

Carolina Panthers Preview

The Carolina Panthers have a 7-6 record this season and are sitting first in the NFC South. They are 8-5 ATS, 7-6 in Over/Under and have a 5-2 home record and a 2-4 away record. The Panthers are coming off a 31-27 home win against the Los Angeles Rams and will face the Buccaneers, Seahawks and Buccaneers next.

Offensively, the Panthers average 19 points per game, ranking 28th in the NFL, while defensively, they allow 22.8 points per game, which is 16th. Carolina averages 311.2 total yards per game (185.7 passing and 125.5 rushing), while allowing 331.1 total yards per game (118.7 rushing and 212.4 passing).

Bryce Young leads the Panthers with 2337 passing yards with 63.4% completed passes and 8 touchdowns. Rico Dowdle leads the team in rushing yards with 929, while Tetairoa McMillan has a team-high 57 receptions for 826 receiving yards, and 6 touchdowns. Defensively, Tre’von Moehrig has a team-high 81 total tackles (50 of them solo), while Derrick Brown leads the team in sacks, with 4.5, while Michael Jackson leads the team with 3 interceptions.

Carolina Panthers @ New Orleans Saints Betting Trends: Week 15

 

Why the New Orleans Saints will win

  • The Panthers have lost each of their last 11 games as favorites.
  • The underdogs have won four of the Panthers’ last five games.
  • The Panthers have failed to cover the spread in each of their last 11 games as favorites.
  • The Saints have covered the spread in each of their last six games as underdogs against the Panthers.
  • The Saints have scored the first touchdown in five of their last six home games against the Panthers.
  • The Panthers have lost the first quarter in three of their last four December games as road favorites against NFC South opponents.
  • The Saints have won the first half in each of their last six games against the Panthers.

Why the Carolina Panthers will win

  • The Saints have lost each of their last eight games without Taysom Hill.
  • The Panthers have won each of their last three games without Chuba Hubbard.
  • The Saints have failed to cover the spread in each of their last five home games without Juwan Johnson.
  • The road team has covered the spread in each of the Saints’ last four games.
  • The Saints have lost the first half in each of their last six games as home underdogs.
  • The Panthers have scored the first touchdown in each of their last four games against NFC South opponents.
  • The Saints have lost the first quarter in seven of their last eight home games.

Total Points Facts

  • Each of the last eight games between teams from the same division have gone OVER the total points line.
  • Each of the Panthers’ six previous games without Chuba Hubbard have gone OVER the total points line.
  • Eight of the Saints’ last nine games have gone UNDER the total points line.

New Orleans Saints Player Prop Facts

  • Alvin Kamara has recorded 100+ rushing and receiving yards in six of his seven previous regular season home appearances against the Panthers.
  • Alvin Kamara has scored the first touchdown in three of his four previous December appearances against the Panthers.
  • Tyler Shough has recorded 239+ passing yards in three of the Saints’ last four games.
  • Chris Olave has recorded 70+ receiving yards in each of his last four appearances following a win.
  • Alvin Kamara has scored at least one touchdown in each of his four previous December appearances against the Panthers.
  • Taysom Hill has recorded 12+ rushing yards in 17 of his last 18 appearances following a road win.
  • Heading into Week 15, Kool-Aid McKinstry has recorded the equal-most interceptions in a single game this season (2 vs Giants, Week 5).

Carolina Panthers Player Prop Facts

  • Tetairoa McMillan has scored the last touchdown in each of the Panthers’ last three games.
  • Bryce Young has recorded 203+ passing yards in each of the Panthers’ last three road games against NFC South opponents.
  • Xavier Legette has recorded 23+ receiving yards in seven of his eight previous appearances against NFC South opponents.
  • Rico Dowdle has scored a touchdown in four of his last five appearances with his team as a favorite against teams that held a losing record.
  • Chuba Hubbard has recorded 32+ rushing yards in each of his last 10 December appearances.
  • Chuba Hubbard has recorded 43+ rushing and receiving yards in each of his last 12 December appearances.
  • Heading into Week 15, Jaycee Horn has recorded the equal-most interceptions in a single game this season (2 vs Jets, Week 7).

Matchup/League Facts

  • Heading into Week 15, the Saints rank 32nd in the NFL in 4th down percentage (33.3%) this season.
  • Heading into Week 15, the Saints rank 32nd in the NFL in red zone percentage (41.2%) this season.
  • Panthers – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 15.
  • Heading into Week 15, the Panthers are the only team to overturn multiple 12+ point 2nd quarter deficits to win this season.

Panthers vs Saints Prediction

In this Panthers vs Saints Prediction, the Panthers are coming as -2.5-point road favorites. The Panthers have been the better team this season, more than twice as many wins as the Saints, playing very good on the road lately, with a 3-1 record in their last 4 road games. On the flip side, the Saints have been atrocious at home this season, having won only once in their six home games played and are 2-6 in their last 8 games. They have been weaker than the Panthers both offensively and defensively, having the third-worst offense in the league and a -8.4 point differential. The value here lies with the road team, so take Carolina and lay the short number on the road.

Nikos Lagouretos's Free Pick: Carolina Panthers -2.5

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