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Panthers vs Steelers Prediction 8/21/25 NFL Picks Today

Pittsburgh Steelers (1-1) vs. Carolina Panthers (0-2)
August 21, 2025 7:00 pm EDT
The Line: Carolina Panthers +4.5; Over/Under: 35.5
(Get latest betting odds)

The Pittsburgh Steelers and Carolina Panthers meet Thursday in NFL preseason action at Bank of America Stadium. Here’s a Panthers vs Steelers Prediction. This article will include a Panthers vs Steelers Pick.

Pittsburgh Steelers Betting Preview

The Pittsburgh Steelers beat the Jaguars, lost to the Buccaneers, and play the Jets next. The Steelers have lost four of their last five preseason games. 


In the victory, Skylar Thompson threw for 113 yards and 1 interception, while Mason Rudolph and Logan Woodside threw for 91 yards, 1 touchdown and 2 interceptions. The Pittsburgh Steelers rushed for 130 yards and Kaleb Johnson led the way with 50 yards. Roman Wilson and Roc Taylor combined for 111 receiving yards on 5 catches while Scotty Miller had 2 catches for 38 yards. Defensively, Sebastian Castro led the Pittsburgh Steelers with 5 tackles, Derrick Harmon had 1 sack, and Miles Killebrew had 1 pass deflection.

Carolina Panthers Betting Preview

The Carolina Panthers lost to the Browns and Texans, and they play the Jaguars next. The Panthers have lost seven of their last eight preseason games.

In the loss, Jack Plummer threw for 83 yards and 2 interceptions, while Andy Dalton and Bryce Young threw for 22 yards on 6 pass attempts. The Carolina Panthers rushed for 78 yards and Kay’Ron Lynch-Adams led the way with 27 yards. Brycen Tremayne and David Moore combined for 72 receiving yards on 6 catches while Rico Dowdle had 1 catch for 15 yards. Defensively, Demani Richardson led the Carolina Panthers with 17 tackles, Christian Rozeboom had 1 sack, and Jon Rhattigan had 1 pass deflection.

Panthers vs Steelers Prediction

I don’t like laying more than a field goal in preseason games, but the Panthers have scored a combined 13 points in their first two games, and they’ve lost seven of their last eight preseason games. At some point, it is what it is. Skylar Thompson and Mason Rudolph have played well in the preseason, and they’re going to get all of the reps in this contest. The Panthers are just a tough sell across the board given what they’ve done in the past couple of regular seasons and exhibitions. I don’t want anything to do with this franchise right now. Give me the Steelers by a touchdown.

Randy Chambers's Free Pick: Pittsburgh Steelers -4.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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