Saints vs Rams
August 22, 2026 4:00 pm EDT
The Line: Saints -2.5 / Rams +2.5 / Over/Under: 37
(Get latest betting odds)
In this article, we will formulate a Saints vs Rams Prediction for this NFL Preseason Week 2 matchup on Saturday, August 22nd. Let’s take a look at the prediction for this NFL matchup.
Los Angeles Rams Preview
The Los Angeles Rams are coming off a 20-12 road victory over Kansas City in their opening game of the preseason, where they outgained their opponents by 321-314 yards and had 52 total plays. Los Angeles had 228 passing yards, 93 rushing yards, and 25/31 completed passes, while the turnover battle was tied at 0-0. The Rams were 2-8 on third down conversions and 2-4 in the red zone.
Ty Simpson led Los Angeles with 21/25 passes and 190 passing yards, with two touchdowns. Jordan Waters had a team-high 37 rushing yards, while Brennan Presley caught 4 passes for a team-high 58 receiving yards. Defensively, Nate Andersen led the Rams with 9 total tackles, 4 of them solo, while Desjuan Johnson had one sack.
New Orleans Saints Preview
The New Orleans Saints are coming off a 20-24 home defeat by Jacksonville in their opening game of the preseason, where they outgained their opponents by 277-275 yards and had 62 total plays. New Orleans had 221 passing yards, 56 rushing yards, and 27/42 completed passes, while the turnover battle was won at 1-2. The Saints were 4-13 on third down conversions and 2-4 in the red zone.
Zach Wilson led New Orleans with 11/16 passes and 145 passing yards, with one touchdown. Audric Estimé had a team-high 28 rushing yards, while Bub Means caught 4 passes for a team-high 77 receiving yards. Defensively, Dalys Beanum led the Saints with 11 total tackles, 6 of them solo, while Michael Heldman had two sacks.
Saints vs Rams Prediction
The Rams are 5-1 in their 6 meetings against the Saints and have won their last five meetings in Los Angeles. Under is 4-2 in their last 6 meetings.
In this Saints vs Rams Prediction, the Saints are coming as -2.5 road favorites. Both teams are coming off opposite outcomes in their opening game of the preseason and now the Rams are playing their preseason opener at home, where they were almost perfect last season and have an excellent history against the Saints. The Rams are currently No.1 at the NFL Power Rankings and are being home dogs against a Saints team currently #21 in the power ranking. Take the Rams by +2.5 in this one.
Nikos Lagouretos's Free Pick: Los Angeles Rams +2.5
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