San Francisco 49ers vs Atlanta Falcons Prediction 10/19/25 NFL Picks Today

The Atlanta Falcons and the San Francisco 49ers meet Sunday in NFL action from Levi’s Stadium. Here’s a 49ers vs Falcons prediction. We will look at this from a betting perspective and determine the best 49ers vs Falcons pick.

Atlanta Falcons Betting Preview

The Falcons managed to go a tepid .500 across their first four games this year. The losses came versus the Tampa Bay Buccaneers and the Carolina Panthers; otherwise it was victories over the Minnesota Vikings and the Washington Commanders in that time. In the 34-27 win over Washington at home, the Falcons came up with a nice 435 yards and 24 first downs on offense. The defense had a great day too, holding Washington to just 1-of-8 on third-down conversion attempts during the victory effort.

In their Monday outing versus the Buffalo Bills, the Falcons jumped out to a 21-7 lead by the end of the first half. Atlanta was outscored 7-3 the rest of the way but still held on for the upset win at home 24-14. QB Michael Penix finished 20-of-32 for 250 yards and a touchdown, while leading rusher Bijan Robinson carried 19 times for 170 yards and a touchdown. Drake London was the team’s leading receiver in the victory with 10 catches for 158 yards and a score.

San Francisco 49ers Betting Preview

Over on the 49ers’ side, they opened up the season with a trio of tight victories. San Francisco took out the Seattle Seahawks 17-13, the New Orleans Saints 26-2` and the Arizona Cardinals 16-15 in that time, but then took a tight loss 26-21 to the Jacksonville Jaguars. Following that home defeat San Francisco got back into the groove with a 26-23 win over the LA Rams. The Niners defense gave up 456 total yards (378 passing) and 7.1 yards per play in that one but also came up with a couple of fumble recoveries on the way to the overtime victory.

In their matchup with the Tampa Bay Buccaneers on Sunday, the 49ers were down by four points heading into the second half. San Francisco was outscored 10-3 the rest of the way and ended up falling 30-19 in the end. QB Mac Jones had a rough outing on 27-of-39 passing for 347 yards and two interceptions while Christian McCaffrey carried 17 times for 54 yards and a score as the leading rusher. Kendrick Bourne added five catches for 142 yards as the team’s leading receiver.

Atlanta Falcons @ San Francisco 49ers Betting Trends: Week 7

Why the San Francisco 49ers will win

• The 49ers have won each of their last nine home games when playing with a rest advantage.
• The Falcons have lost each of their last 10 games as road underdogs following a win.
• The Falcons have failed to cover the spread in 10 of their last 11 Week 7 games.
• The 49ers have covered the spread in each of their last four games as home favorites following a loss.
• The 49ers have won the first quarter in each of their last seven October home games against NFC opponents.
• The 49ers have scored the first touchdown in each of their last seven games as home favorites against NFC South opponents.
• The 49ers have won the first half in seven of their last eight games as favorites against NFC South opponents.

Why the Atlanta Falcons will win

• The underdogs have won each of the 49ers’ last five Week 7 games.
• The 49ers have lost each of their last seven Week 7 home games.
• The 49ers have failed to cover the spread in each of their last 10 Sunday games against teams that held a winning record.
• The Falcons have covered the spread in each of their last six October road games against NFC opponents.
• The underdogs have won the first quarter in four of the Falcons’ last five games.
• The Falcons have scored the first touchdown in four of their last five games.
• The 49ers have lost the first half in each of their last eight Week 7 home games.

Total Points Facts

• Seven of the 49ers’ last eight home games following a loss have gone OVER the total points line.
• Each of the Falcons’ last five Week 7 games against NFC opponents have gone UNDER the total points line.

San Francisco 49ers Player Prop Facts

• Christian McCaffrey has scored at least one touchdown in each of his last eight October appearances.
• Brian Robinson has recorded 24+ rushing and receiving yards in 21 of his last 22 appearances following a loss.
• Brock Purdy has recorded 255+ passing yards in each of the 49ers’ last seven games as favorites following a loss.
• Demarcus Robinson has recorded 20+ receiving yards in each of his last six appearances.
• Brian Robinson has recorded 18+ rushing yards in 22 of his 23 previous Sunday home appearances.
• Brock Purdy has recorded 22+ completions in each of his last four appearances.
• Heading into Week 7, Eddy Pineiro ranks 1st in the NFL in made field goals (15) this season.

Atlanta Falcons Player Prop Facts

• Bijan Robinson has scored two touchdowns in three of the Falcons’ last four games following a home win.
• Bijan Robinson has scored at least one touchdown in each of the Falcons’ last four October games.
• Bijan Robinson has recorded 111+ rushing and receiving yards in each of the Falcons’ last six games.
• Kirk Cousins has recorded 274+ passing yards in four of his last five appearances with his team as an underdog against NFC opponents.
• Kyle Pitts has recorded 47+ receiving yards in each of the Falcons’ last five October games against NFC opponents.
• Bijan Robinson has recorded 86+ rushing yards in seven of the Falcons’ last eight games following a win.
• Kirk Cousins has recorded 23+ completions in each of his last seven October appearances with his team as an underdog against NFC opponents.
• Heading into Week 7, Bijan Robinson has recorded the longest touchdown reception of the season (81 vs Bills, Week 6).

Matchup/League Facts

• 49ers – four different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 7.
• 49ers – three different players have recorded 90+ receiving yards in a game this season – equal-most in the NFL, heading into Week 7.
• Heading into Week 7, the Falcons rank 1st in the NFL in yards allowed per game (253.4) this season.
• Heading into Week 7, the Falcons rank 1st in the NFL in rushing yards per game (151.2) this season.

49ers vs Falcons Prediction

I’ll go with the Falcons. Probably not touching this one, though. On Monday Atlanta played very well at home and dispatched a strong Bills team. The Falcons defense was great, giving up 291 yards (157 passing), 17 first downs, 2-of-9 on third-down tries and 5.4 yards per play alongside two interceptions. The offense accounted for 443 yards total, including 210 on the ground. Atlanta has now won three of tier last four games, scoring 22 or more points in each of the victories during that time. This weekend will serve as a solid test, however. We’ll get to see what the Falcons can do on a cross-country road trip. If the offense holds up we should have a competitive performance.

As for the Niners, they didn’t have the greatest game on Sunday during their road loss to the Bucs. San Francisco had a couple of interceptions alongside nine total penalties for 65 yards, going 7-of-16 on third downs with just 67 rushing yards. The defense held Tampa Bay to just 3-of-8 on third downs but also gave up 7.0 yards per play on average. The 49ers aren’t the most consistent scoring team in the world this year; they’ve been below 22 points in four of six games so far and have topped out at 26 points (twice). I’m not super enthused about their cover chances these days.