Titans vs Colts Prediction 9/21/25 NFL Picks Today

The Indianapolis Colts and the Tennessee Titans meet Sunday in NFL action from Nissan Stadium. Here’s a Titans vs Colts prediction. We will look at this from a betting perspective and determine the best Titans vs Colts pick.

Indianapolis Colts Betting Preview

The Colts didn’t have a ton of issues in their opener this year, taking on the Miami Dolphins at home. Indianapolis scored points in every quarter—including 17 in the second alone—on the way to a dominant 33-8 victory. QB Daniel Jones was 22-of-29 for 272 yards and a TD, while Jonathan Taylor led the rush on 18 carries for 71 yards. (Jones also rushed in a pair of scores himself.) Tops in receiving was Michael Pittman with six grabs for 80 yards and the TD. Tyler Warren would add seven catches for 76 yards.

In game two last weekend versus the Denver Broncos, the Colts were fighting it out the whole way, taking a one-point deficit into the break. At the end of the game, Indianapolis had a 29-28 victory—thanks in part to a wild finish. QB Daniel Jones was 23-of-34 for 316 yards and a score, while also posting a rush TD. Jonathan Taylor carried 25 times for 165 yards, and Tyler Warren topped the receivers on four catches for 79 yards in the tight win.

Tennessee Titans Betting Preview

Over on the Tennessee side, they took on the aforementioned Denver Broncos in their first game of the season. The Titans were within one point by the fourth quarter but ultimately fell 20-12. QB Cameron Ward finished with 112 yards on 12-of-28 passing. Tops in rushing was Tony Pollard with 18 totes for 60 yards, and Pollard also led the receiving corps with his lone 29-yard catch. Calvin Ridley added four catches for 27 yards as well.

Matched up against the Los Angeles Rams on Sunday, the Titans held a 13-10 edge by halftime. Tennessee gave up 23 points in the final two quarters though, resulting in a loss 33-19 in the end. Ward was 19-of-33 for 175 yards and a TD this time, and Pollard again topped the rush with 92 yards on his 20 carries. Ridley was atop the receiving corps again with three catches for 57 yards, and Epic Ayomanor caught four balls for 56 yards and a touchdown.

Indianapolis Colts @ Tennessee Titans Betting Trends: Week 3

Why the Tennessee Titans will win

• The home team has won each of the Colts’ last six games.
• The Colts have lost each of their last six road games following a win.
• The Colts have failed to cover the spread in each of their last six September games as road favorites.
• The home team has covered the spread in six of the Colts’ last seven games.
• The Colts have lost the first half in each of their last seven road games following a home win.
• The Titans have won the first quarter in each of their last four games as home underdogs against AFC opponents.
• The Titans have scored the first touchdown in each of their last four games as home underdogs against AFC opponents.

Why the Indianapolis Colts will win

• The Titans have lost each of their last eight games.
• The Colts have won each of their last nine games as favorites against AFC opponents.
• The Titans have failed to cover the spread in each of their last nine home games.
• The Colts have covered the spread in each of their last six September games against AFC opponents.
• The Titans have lost the first half in each of their last five games against AFC opponents.
• The Colts have won the first quarter in each of their last four road games against AFC opponents.
• The Colts have scored the first touchdown in each of their last six road games against AFC opponents.

Total Points Facts

• Each of the Colts’ last seven September games as favorites have gone UNDER the total points line.
• Each of the Titans’ last four games as home underdogs against the Colts have gone OVER the total points line.

Tennessee Titans Player Prop Facts

• Tyler Lockett has recorded 30+ receiving yards in each of his nine previous appearances against AFC South opponents.
• Tyjae Spears has scored at least one touchdown in each of his last three appearances following a home loss.
• Tyjae Spears has recorded 40+ rushing yards in four of the Titans’ last five home games as slight underdogs (<+3.5 points).
• Tony Pollard has recorded 89+ rushing and receiving yards in each of his last seven September appearances with his team as an underdog.
• Heading into Week 3, Joey Slye ranks T1st in the NFL in 50+ yard field goals made (3) this season.

Indianapolis Colts Player Prop Facts

• Jonathan Taylor has scored at least one touchdown in nine of his last 10 appearances with the Colts as favorites against teams with a losing record.
• Michael Pittman Jr. has scored the last touchdown in each of his last three appearances with the Colts as road favorites against AFC South opponents.
• Daniel Jones has recorded 205+ passing yards in each of his last five appearances against AFC opponents.
• Jonathan Taylor has recorded 91+ rushing yards in eight of his last nine appearances with the Colts as favorites.
• Jonathan Taylor has recorded 98+ rushing and receiving yards in each of his last eight appearances with the Colts as favorites.
• Michael Pittman Jr. has recorded 63+ receiving yards in each of the Colts’ last seven games as favorites following a win.
• Daniel Jones has recorded 22+ completions in each of his last six appearances following a win.
• Heading into Week 3, Jonathan Taylor ranks 1st in the NFL in rushing yards (236) this season.

Matchup/League Facts

• Titans – one different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
• Titans – one different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
• Colts – one different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
• Colts – one different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.

Titans vs Colts Prediction

I’ll lean toward Indianapolis. You could probably call this one either way, though. In reality I’m probably staying away all together. In any case, the Colts got a late gift in the form of a last-second penalty on Sunday, resulting in an improbable comeback win. It was a pretty sloppy game overall prior to that however, as Indy accounted for 11 of the game’s 19 flags. The good news however, is that the Colts offense was quite well-rounded on 473 yards (306 passing), 7.1 yards per play and 26 first downs. On defense Indianapolis surrendered 324 yards (206 passing), 6.0 yards per play and 23 first downs but didn’t do too badly on third-down stops (4-of-9). Including the 33-point drubbing of the Dolphins in Week 1, that gives the Colts a combined 62 points across the first two outings. That’s not too shabby. If Indianapolis can keep it up this weekend, they’ll be in a great position.

As for the Titans, they played a pretty mistake-prone game in their loss to the Rams. Tennessee posted 10 penalties for 62 yards, while a tepid offense collected just 252 yards (143 passing), 3.9 yards per play, 18 first downs and a 6-of-15 run on third-down tries. The Titans held LA in check on third downs (5-of-12) pretty well but gave up 439 yards total and 7.4 yards per play. I don’t see them keeping a cover pace on Indianapolis, but it’s a coin flip.