Blackhawks vs Sabres Prediction 11/21/25 NHL Picks Today

In this article, we will formulate a Blackhawks vs Sabres Prediction for this NHL game on Friday, November 21^st. Let’s take a look at the prediction for this NHL matchup.

Buffalo Sabres Preview

The Sabres have 18 points this season with a 7-9-4 record, and are 8-12 ATS and 11-7 in over/under. They have a 6-4-2 home record and a 1-5-2 road record and are sitting 8th in the Atlantic Division. They are coming off a 6-2 home loss to the Flames and will face the Hurricanes and Penguins next.

Offensively, the Sabres are averaging 2.85 goals per game and are scoring 16.39% of their power play opportunities. Defensively, they are allowing 3.55 goals per game and are killing 89.83% of their opponent’s power plays.

Tage Thompson leads Buffalo with 18 points, 10 goals and 8 assists, while Alex Tuch follows with 16 points, 7 goals and 9 assists. Alex Lyon is the starting goalie for the Sabres, and he has a 3-5-4 record, with 3.07 GAA and .907 SV%. Colten Ellis is the backup goalie and he has a 3-2-0 record, with 3.41 GAA and .896 SV%.

Chicago Blackhawks Preview

The Blackhawks have 24 points this season with a 10-6-4 record, and are 16-4 ATS and 7-12 in over/under. They have a 5-3-2 home record and a 5-3-2 road record and are sitting 4th in the Central Division. They are coming off a 3-2 home loss to the Kraken and will face the Avalanche and Wild next.

Offensively, the Blackhawks are averaging 3.30 goals per game and are scoring 24.11% of their power play opportunities. Defensively, they are allowing 2.55 goals per game and are killing 83.61% of their opponent’s power plays.

Connor Bedard leads Chicago with 29 points, 13 goals and 16 assists, while Tyler Bertuzzi follows with 17 points, 10 goals and 7 assists. Spencer Knight is the starting goalie for the Blackhawks, and he has a 7-4-3 record, with 2.47 GAA and .922 SV%. Arvid Söderblom is the backup goalie and he has a 3-2-1 record, with 2.52 GAA and .912 SV%.

Chicago Blackhawks @ Buffalo Sabres Betting Trends: November 21, 2025

Why the Buffalo Sabres will win

• The Sabres have won seven of their last eight games against the Blackhawks.
• The Blackhawks have lost each of their last four games at KeyBank Center.
• The home team has covered the puck line in four of the last five games between the Blackhawks and Sabres.
• The Sabres have won the third period in seven of their last eight games against the Blackhawks.

Why the Chicago Blackhawks will win

• The Blackhawks have won each of their last five games as underdogs following a home loss.
• The Sabres have lost each of their last six night games against Central Division opponents.
• The Blackhawks have covered the puck line in each of their last 11 games against Atlantic Division opponents.
• The Sabres have failed to cover the puck line in each of their last seven games as favorites following a home loss.
• The Sabres have lost the second period in each of their last seven games as favorites against Western Conference opponents when leading after the first period.

Total Goals Facts

• Seven of the Sabres’ last eight games following a loss have gone OVER the total goals line.
• Each of the last seven Friday games at KeyBank Center have gone OVER the total goals line.
• Six of the Blackhawks’ last seven games on the second leg of a back-to-back have gone OVER the total goals line.
• The ‘Over 1.5 Goals Period 3′ market has hit in each of the Blackhawks’ last 10 games following a home loss.
• The ‘Over 1.5 Goals Period 3′ market has hit in each of the Sabres’ last nine home games against the Blackhawks.

Buffalo Sabres Player Prop Facts

• Jack Quinn has recorded an assist in five of his last six appearances with the Sabres as home favorites against Central Division opponents.
• Tage Thompson has scored a goal in each of the Sabres’ last four games.
• Tage Thompson has recorded at least one point in each of his last seven Friday appearances against Central Division opponents.
• Tage Thompson is the only player in the league to have recorded 5+ shots in five or more consecutive appearances this season.

Chicago Blackhawks Player Prop Facts

• Tyler Bertuzzi has scored the first goal in three of his last four appearances in night games.
• Connor Bedard has recorded at least one assist in each of the Blackhawks’ last six road games.
• Frank Nazar has recorded at least one point in each of his last eight appearances against Atlantic Division opponents.
• Andre Burakovsky has scored a goal in five of the Blackhawks’ last six road games.
• Connor Bedard is one of only two players in the league to have recorded two or more hat tricks this season.

Matchup/League Facts

• The Buffalo Sabres rank 1st in the league in penalty kill percentage this season (89.83%).
• The Buffalo Sabres rank 27th in the league for goals against per game this season (3.55).
• The Chicago Blackhawks rank 3rd in the league for goals against per game this season (2.55).
• The Chicago Blackhawks are one of four teams to rank in the top 10 for both goals scored and goals conceded per game this season.

Blackhawks vs Sabres Prediction

The Sabres are 7-1 in their last 8 meetings against the Blackhawks. In this Blackhawks vs Sabres Prediction, the Sabres are coming as -190 home favorites. The Sabres are being overvalued in this spot, as the Blackhawks are playing the second leg of a back-to-back. Chicago has been better both offensively and defensively than the Sabres, who are just 2-6 in their last 8 games and 1-3 in their last 4 at home. I will take a stab with the Blackhawks on the moneyline on the road for some nice plus money.