Red Wings vs Sabres Prediction 10/22/25 NHL Picks Today

In this article, we will formulate a Red Wings vs Sabres Prediction for this NHL game on Wednesday, October 22^nd. Let’s take a look at the prediction for this NHL matchup.

Buffalo Sabres Preview

The Sabres have 4 points this season with a 2-4 record, and are 2-4 ATS and 1-5 in over/under. They have a 2-2 home record and a 0-2 road record and are sitting 6th in the Atlantic Division. They are coming off a 4-2 road loss to the Canadiens and will face the Maple Leafs, Maple Leafs and Blue Jackets next.

Offensively, the Sabres are averaging 2.50 goals per game (ranking 24th in the league) and are scoring 26.32% of their power play opportunities. Defensively, they are allowing 3.00 goals per game (ranking 15th in the league) and are killing 95.83% of their opponent’s power plays.

Zach Benson leads Buffalo with 6 points, zero goals and 6 assists, while Rasmus Dahlin follows with 5 points, zero goals and 5 assists. Alex Lyon is the starting goalie for the Sabres, and he has a 2-4 record, with 2.55 GAA and .924 SV%.

Detroit Red Wings Preview

The Red Wings have 10 points this season with a 5-1 record, and are 5-1 ATS and 1-5 in over/under. They have a 4-1 home record and a 1-0 road record and are sitting 1st in the Atlantic Division. They are coming off a 4-2 home win over the Oilers and will face the Islanders, Blues and Blues next.

Offensively, the Red Wings are averaging 3.33 goals per game (ranking 9th in the league) and are scoring 22.22% of their power play opportunities. Defensively, they are allowing 2.33 goals per game (ranking 5th in the league) and are killing 92.31% of their opponent’s power plays.

Dylan Larkin leads Detroit with 11 points, 5 goals and 6 assists, while Alex DeBrincat follows with 6 points, zero goals and 6 assists. Cam Talbot is the starting goalie for the Red Wings, and he has a 3-0 record, with 1.78 GAA and .932 SV%. John Gibson is the backup goalie and he has a 2-1 record, with 2.99 GAA and .873 SV%.

Detroit Red Wings @ Buffalo Sabres Betting Trends: October 22, 2025

Why the Buffalo Sabres will win

• The home team has won six of the last seven games between the Red Wings and Sabres.
• The Red Wings have lost four of their last five night games at KeyBank Center following a home win.
• The favorites have covered the puck line in five of the Red Wings’ last six games at KeyBank Center.
• The Red Wings have failed to cover the puck line in four of their last five games at KeyBank Center following a win.
• The favorites have won the first period in each of the Red Wings’ last six games at KeyBank Center.

Why the Detroit Red Wings will win

• The underdogs have won each of the Red Wings’ last six games.
• The Sabres have lost seven of their last eight games against opponents on a winning streak.
• The Red Wings have covered the puck line in each of their last eight games as underdogs.
• The Sabres have failed to cover the puck line in each of their last seven Wednesday games as home favorites.
• The Sabres have lost the second period in each of their last eight night games following a road loss.

Total Goals Facts

• Each of the last six games between the Red Wings and Sabres at KeyBank Center have gone OVER the total goals line.
• Each of the Red Wings’ last six night games at KeyBank Center have gone OVER the total goals line.
• Three of the last four games between teams from the same division have gone OVER the total goals line.
• The ‘Over 1.5 Goals Period 2′ market has hit in 20 of the Sabres’ last 21 games as favorites against Eastern Conference opponents.
• The ‘Over 1.5 Goals Period 3′ market has hit in 14 of the Red Wings’ last 15 road games.

Buffalo Sabres Player Prop Facts

• Alex Tuch has recorded at least one point in each of the Sabres’ last six games as favorites against Eastern Conference opponents.
• Rasmus Dahlin has recorded at least one assist in seven of his last eight appearances with the Sabres as favorites against the Red Wings.
• Alex Tuch has scored at least one goal in each of the Sabres’ last six games as favorites against Eastern Conference opponents.

Detroit Red Wings Player Prop Facts

• Lucas Raymond has scored a goal in each of the Red Wings’ last four games as underdogs against the Sabres.
• Lucas Raymond has recorded at least one point in each of the Red Wings’ last nine games against the Sabres.
• Lucas Raymond has recorded at least one assist in eight of the Red Wings’ last nine games against the Sabres.

Matchup/League Facts

• The Buffalo Sabres rank 2nd in the league in penalty kill percentage this season (95.83%).
• The Buffalo Sabres rank 28th in the league for goals per game this season (2.50).
• The Detroit Red Wings rank 4th in the league in penalty kill percentage this season (92.31%).
• The Detroit Red Wings are one of five teams to rank in the top 10 for both goals scored and goals conceded per game this season.

Red Wings vs Sabres Prediction

The Red Wings were 3-1 in their 4 meetings against the Sabres last season, but were 1-1 in their two meetings in Buffalo. They are 5-1 in their last 6 overall meetings, but the Sabres are 3-2 in their last 5 meetings in Buffalo. Over is 7-3 in their last 10 meetings.

In this Red Wings vs Sabres Prediction, the Sabres are coming as -115 home favorites. The wrong team is favored in this spot, as the Red Wings have been one of the best teams in hockey so far, and surely one of the biggest surprises. They have five consecutive wins after losing their season opener and have won their only road game so far, and have been dominating the Sabres in recent years. Detroit is better both offensively and defensively, and have a better goaltending. Take the Detroit Red Wings on the moneyline as slight road dogs in this one.