San Francisco 49ers vs Arizona Cardinals Prediction 10-6-24 NFL Picks

The Arizona Cardinals and the San Francisco 49ers meet Sunday in NFL action from Levi’s Stadium. Here’s a San Francisco 49ers vs Arizona Cardinals prediction. We will look at this from a betting perspective and determine the best 49ers vs Cardinals pick.

Arizona Cardinals Betting Preview

Arizona kicked off their season with a matchup versus the Buffalo Bills. That one turned into a 34-28 loss, but the Cardinals rebounded in game two with a dominant 41-10 win over the Rams. Game three was another loss though, as Arizona fell 20-13 versus the Lions.

The Cardinals were tied 7-7 after the first quarter versus the Washington Commanders last weekend. Arizona gave up double-digit points in each of the final three quarters however and lost 42-14. QB Kyler Murray finished with 142 yards and a TD, while James Conner led the rush on 18 carries for 104 yards and a TD.

San Francisco 49ers Betting Preview

Over on the 49ers’ side, they didn’t have too much trouble with the New York Jets in their opener, cruising to a 32-19 win. The next two games were losses for San Francisco however, as they fell 23-17 versus the Vikings and 27-24 against the Rams.

Last weekend versus the New England Patriots, the 49ers got back into the win column in a big way. San Francisco was up 20-3 by halftime and ended up with a 30-13 result. QB Brock Purdy logged 288 yards, one TD and one interception. Jordan Mason paced the rush with 123 yards and a score of his own.

Total Points Facts

• Each of the 49ers’ last eight games against the Cardinals following a win has gone OVER the total points line.
• Seven of the Cardinals’ last eight games as underdogs against the 49ers have gone OVER the total points line.
• Four of the last five games between NFC West teams have gone OVER the total points line.

San Francisco 49ers Player Prop Facts

• Brock Purdy has thrown two or more touchdowns in seven of his eight previous regular-season home appearances against NFC opponents.
• Brock Purdy has recorded 252+ passing yards in each of the 49ers’ last eight home games as heavy favorites (>-7.0 points).
• Christian McCaffrey has recorded 38+ receiving yards in each of his six previous October appearances against NFC West opponents.
• Elijah Mitchell has recorded 36+ rushing yards in each of his nine previous regular-season appearances against NFC West opponents.
• Christian McCaffrey has scored at least one touchdown in 21 of his last 22 appearances following a win.
• Elijah Mitchell has recorded 36+ rushing and receiving yards in each of his nine previous regular-season appearances against NFC West opponents.
• Christian McCaffrey has scored two or more touchdowns in three of his last four appearances against NFC West opponents.
• Brock Purdy has recorded 22+ completions in four of his last five appearances against NFC opponents.

Arizona Cardinals Player Prop Facts

• Kyler Murray has thrown two or more touchdowns in each of his last six regular-season appearances with the Cardinals as road underdogs against NFC opponents.
• Kyler Murray has recorded 239+ passing yards in each of his four previous Week 5 appearances.
• James Conner has recorded 17+ receiving yards in 10 of his last 12 appearances following a home loss.
• James Conner has recorded 104+ rushing yards in four of the Cardinals’ last five games against NFC opponents.
• James Conner has scored at least one touchdown in each of the Cardinals’ last six games following a loss.
• James Conner has recorded 86+ rushing and receiving yards in nine of his last 10 appearances following a home loss.
• Kyler Murray has recorded 23+ completions in each of his last seven regular season road appearances against NFC opponents.

San Francisco 49ers vs Arizona Cardinals Prediction

I’m leaning 49ers. San Francisco handled the Patriots pretty easily last weekend, thanks mostly to a good defensive effort. The Niners gave up just 216 yards (143 passing), 3.5 yards per play, 12 first downs, and 5-of-16 on third-down tries. San Francisco also logged three takeaways but had a couple of offensive turnovers themselves to help even things out.

As for Arizona, they posted just 296 yards (115 passing), 17 first downs, and 4-of-11 on third-down conversions during their blowout loss to Washington. The Cardinals gave up 29 first downs on defense, along with a blistering 10-of-13 on third- and fourth-down conversions. San Francisco should have some ample offensive opportunities here if the Cardinals can’t straighten themselves out.