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Brewers vs Astros Prediction 5/5/25 MLB Picks Today

Houston Astros (17-16) vs. Milwaukee Brewers (17-18)
May 5, 2025 7:40 pm EDT
The Line: Milwaukee Brewers -115 / Houston Astros -105; Over/Under: 8
(Get latest betting odds)

In this article, we will formulate a Brewers vs Astros prediction for this MLB game on Monday, May 5, at American Family Field in Milwaukee, Wisconsin. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Betting Preview

The Houston Astros (17-16, 6-9 Away) won the series against the Kansas City Royals but then lost two of three games to the Chicago White Sox on the road.  The Astros did win Game 2, but lost the following one, 5-4. In a game that was shortened due to rain, the Astros had a 4-0 lead but still left empty-handed. Zach Dezenzo and Mauricio Dubon led the offense with two RBI, while Lance McCullers Jr. pitched for 3.2 innings in a no-decision, allowing no runs on three hits with four strikeouts and three walks. Steven Okert took the loss.

This year, the Astros average 4.00 runs per game (19th in the MLB) on a .243/.314/.370 triple-slash. When it comes to pitching, the Astros’ staff has a 3.34 ERA (5th) and 1.12 WHIP (2nd). Yordan Alvarez leads the Astros with a .210 batting average, three home runs, and 18 RBI this season.

Ronel Blanco will take the mound for the Astros on Monday. The 31-year-old right-hander has a 2-2 record in six starts this year with a 5.08 ERA and 1.31 WHIP in 28.1 innings.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers (17-18, 10-6 Home) were on a three-game losing skid, during which they scored just two runs. They managed to avoid the fourth loss in a row with a 4-0 home victory over the Chicago Cubs, and also avoided getting swept. Caleb Durbin led the team with two RBI, while Freddy Peralta allowed no runs on four hits with seven strikeouts and one walk over 6.0 innings of work.

This season, the Brewers average 4.71 runs per game (10th in the MLB) on a .238/.316/.356 slash line. Regarding pitching, the Brewers’ staff has a 4.32 ERA (21st) and 1.34 WHIP (21st). Jackson Chourio leads the Brewers with a .255 batting average, six home runs, and 24 RBI this season.

The projected starting pitcher for the Brewers is Tobias Myers, who is 0-0 in two starts this season, with a 5.14 ERA and 1.86 WHIP in 7.0 innings.

Total Runs Facts

  • Each of the Astros’ last seven games as underdogs against National League opponents have gone UNDER the total runs line.
  • Three of the Brewers’ last four games have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Astros’ last 10 games as underdogs against National League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last five night games between the Astros and Brewers.

Matchup/League Facts

  • The Brewers rank 26th in the league for slugging percentage this season (.356).
  • The Brewers rank T23rd in the league for home runs this season (28).
  • The Astros rank 4th in the league for opponent batting average this season (.215).
  • The Astros rank T4th in the league for runs allowed this season (119).

Brewers vs Astros Prediction

The teams have traded wins in the last couple of years, as each recorded five in the previous ten H2H duels. Seven of Houston’s last ten games went Over, and I am going with another Over in this one because of the pitching matchup. Ronel Blanco allowed multiple runs in all but one start this year. Tobias Myers is more of a reliever than a starter, but Milwaukee has numerous starters on IL at the moment, so Myers will open the game on Monday. I am backing the Astros to score multiple runs off him. Back the Over.

Oliver Zivic's Free Pick: Over 7.5

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Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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