Yankees vs Padres Prediction 5/6/25 MLB Picks Today

In this article, we will formulate a Yankees vs Padres prediction for this MLB game on Tuesday, May 6, at Yankee Stadium in Bronx, New York. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Betting Preview

The San Diego Padres (23-11, 9-7 Away) are looking to match their longest winning streak of the season after winning the previous six games. After sweeping the Giants and Pirates, the Padres beat the Yankees in Game 1 of the current series. San Diego was 3-0 down until the 8th inning, but scored four unanswered to secure a 4-3 victory. Manny Machado and Xander Bogaerts led the offense with two RBI, while Nick Pivetta pitched for 5.0 innings in a no-decision, allowing three runs (two earned) on five hits with five strikeouts and four walks. Ryan Bergert was credited with the win.

This year, the Padres average 4.03 runs per game (18th in the MLB) on a .260/.329/.393 triple-slash. When it comes to pitching, the Padres’ staff has a 2.75 ERA (1st) and 1.14 WHIP (4th). Fernando Tatis Jr. leads the Padres with a .317 batting average, eight home runs, and 18 RBI this season.

Michael King will take the mound for the Padres on Tuesday. The 29-year-old right-hander has a 4-1 record in seven starts this year with a 2.09 ERA and 1.01 WHIP in 38.2 innings.

New York Yankees Betting Preview

The New York Yankees (19-16, 11-8 Home) are hoping to avoid the fourth loss in a row for the first time this year after losing the previous three. The Yankees lost the series to the Orioles and Rays and opened the current series against the Padres with a 4-3 defeat. In that game, Trent Grisham led the offense with two RBI, while Carlos Rodon pitched for 6.2 innings in a no-decision, allowing no runs on three hits with five strikeouts and one walk. Luke Weaver took the loss.

This season, the Yankees average 5.50 runs per game (2nd in the MLB) on a .262/.346/.470 slash line. Regarding pitching, the Yankees’ staff has a 3.62 ERA (10th) and 1.20 WHIP (8th). Aaron Judge leads the Yankees with a .414 batting average, 11 home runs, and 33 RBI this season.

The projected starting pitcher for the Yankees is Clarke Schmidt, who is 0-1 in three starts this season, with a 5.52 ERA and 1.43 WHIP in 14.2 innings.

Why the Padres will beat the Yankees

• The Padres have won seven of their last eight night games against AL East opponents following a win.
• The Yankees have lost each of their last four night games against teams that held a winning record.
• The Padres have covered the run line in seven of their last eight night games against AL East opponents following a win.
• The Yankees have failed to cover the run line in five of their last six night games against NL West opponents.

Total Runs Facts

• Eight of the Padres’ last nine games against American League opponents have gone UNDER the total runs line.
• Five of the Yankees’ last six home games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last four games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Yankees’ last 12 home games against NL West opponents.

Matchup/League Facts

• The Yankees rank 1st in the league for on-base percentage this season (.344).
• The Yankees rank 1st in the league for opponent batting average this season (.204).
• The Padres rank T1st in the league for hits allowed this season (231).
• The Padres rank 1st in the league for runs allowed this season (98).

Yankees vs Padres Prediction

The Yankees won six of the previous ten H2H encounters, including four of the last six. I am giving a slight advantage to the Padres not only because they are in a better form, but also because of the pitching matchup. Michael King allowed more than two runs only once in his last six starts, and one in total in the previous two starts. Clarke Schmidt is not on the same level as King, and I am sure the Padres will score several runs off him on Tuesday.